Gene Symbol: hsp90
Description: Hsp90 chaperone
Alias: git10, swo1, Hsp90 chaperone
Species: fission yeast

Top Publications

  1. Hoffman C, Winston F. Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway. Genes Dev. 1991;5:561-71 pubmed
    ..Additional experiments demonstrate that this cAMP signaling pathway is independent of the S. pombe ras1 gene and works by activation of cAMP-dependent protein kinase. ..
  2. Munoz M, Jimenez J. Genetic interactions between Hsp90 and the Cdc2 mitotic machinery in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet. 1999;261:242-50 pubmed
    ..overexpression of weel led to the isolation of a new allele of swo1 (named swo1-w1), the gene coding for chaperone Hsp90, which is required to stabilise Weel...
  3. Saitoh S, Chabes A, McDonald W, Thelander L, Yates J, Russell P. Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell. 2002;109:563-73 pubmed
    ..cid13 mutants have reduced dNTP pools and are sensitive to hydroxyurea, an RNR inhibitor. We propose that Cid13 defines a cytoplasmic form of poly(A) polymerase important for DNA replication and genome maintenance. ..
  4. Ishida M, Tomomari T, Kanzaki T, Abe T, Oka T, Yohda M. Biochemical characterization and cooperation with co-chaperones of heat shock protein 90 from Schizosaccharomyces pombe. J Biosci Bioeng. 2013;116:444-8 pubmed publisher
    The characterization of Hsp90 from the fission yeast Schizosaccharomyces pombe was performed. Hsp90 of S. pombe existed as a dimer and exhibited ATP-dependent conformational changes...
  5. Shiozaki K, Akhavan Niaki H, McGowan C, Russell P. Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe. Mol Cell Biol. 1994;14:3742-51 pubmed
    ..a multicopy suppressor gene of swo1-26, a temperature-sensitive mutation of a gene encoding the heat shock protein hsp90. The ptc1+ gene product is a 40-kDa protein with approximately 24% identity to a rat PP2C protein...
  6. Santo P, Blanchard B, Hoffman C. The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways. J Cell Sci. 1996;109 ( Pt 7):1919-1925 pubmed
  7. Turnbull E, Martin I, Fantes P. Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90. FEBS J. 2005;272:4129-40 pubmed
    ..can also sustain cellular viability, indicating that Cdc37 dimerization and interactions with the cochaperone Hsp90 may not be essential for Cdc37 function in S. pombe...
  8. Nicolas E, Lee M, Hakimi M, Cam H, Grewal S, Shiekhattar R. Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functions. J Biol Chem. 2006;281:35983-8 pubmed
    ..Importantly, we show that SWIRM1 is not only required for optimum transcription of its target genes but also display a global role in regulation of antisense transcription. ..
  9. Alaamery M, Hoffman C. Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling. Genetics. 2008;178:1927-36 pubmed publisher
    ..pombe Hsp90 chaperone protein...

More Information


  1. Goes F, Martin J. Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1. Eur J Biochem. 2001;268:2281-9 pubmed
    ..and activity of Wee1 from the fission yeast Schizosaccharomyces pombe is critically dependent on functional Hsp90 chaperones...
  2. Ki S, Kasahara K, Kwon H, Ishigami K, Kitahara T, Beppu T, et al. Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast. Biosci Biotechnol Biochem. 2001;65:2528-34 pubmed
    ..A biologically active derivative of radicicol with a biotin moiety at the C-11 position bound Swo1, an Hsp90 homologue in S. pombe...
  3. Mishra M, D souza V, Chang K, Huang Y, Balasubramanian M. Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function. Eukaryot Cell. 2005;4:567-76 pubmed
    ..Biochemical analyses have shown that a complex of Hsp90 and the Caenorhabditis elegans UCS domain protein UNC-45 prevent myosin head aggregation, thereby allowing it to ..
  4. Santino A, Tallada V, Jimenez J, Garzón A. Hsp90 interaction with Cdc2 and Plo1 kinases contributes to actomyosin ring condensation in fission yeast. Curr Genet. 2012;58:191-203 pubmed publisher
    ..We found that in temperature-sensitive hsp90-w1 mutant cells, encoding an Hsp90 mutant protein, ring components were recruited to form a cortical network at ..
  5. Wang C, Chen W, Wang S. Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe. Mol Cell Biol. 2013;33:1244-53 pubmed publisher
    ..Together, these results highlight the diverse P-body protein compositions between different species and might help to provide insight into their evolutionary paths...
  6. Ratzke C, Hellenkamp B, Hugel T. Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery. Nat Commun. 2014;5:4192 pubmed publisher
    ..Many molecular machines, like Hsp90, work far from equilibrium by utilizing the energy of ATP hydrolysis...