Gene Symbol: gtr2
Description: putative Gtr1/RagA G protein Gtr2
Species: fission yeast
Laor D, Cohen A, Pasmanik Chor M, Oron Karni V, Kupiec M, Weisman R. Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway. Mol Cell Biol. 2014;34:794-806 pubmed publisher
..Taken together, our findings suggest a central role for Isp7 in amino acid homeostasis and the presence of isp7(+)-dependent regulatory loops that affect both TORC1 and TORC2. ..
Ma N, Ma Y, Nakashima A, Kikkawa U, Furuyashiki T. The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast. PLoS ONE. 2016;11:e0156239 pubmed publisher
..05c), a homolog of a Ragulator component LAMTOR2, as well as the loss of Gtr1 or Gtr2 phenocopies the loss of Npr2 or Npr3, homologs of GATOR components Nprl2 or Nprl3, respectively...
Chia K, Fukuda T, Sofyantoro F, Matsuda T, Amai T, Shiozaki K. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. elife. 2017;6: pubmed publisher
..identified in the model organism Schizosaccharomyces pombe a Ragulator-like complex that tethers the Gtr1-Gtr2 Rag heterodimer to the membranes of vacuoles, the lysosome equivalent in yeasts...
Valbuena N, Guan K, Moreno S. The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. J Cell Sci. 2012;125:1920-8 pubmed publisher
..We have investigated the role of the Rag GTPases Gtr1 and Gtr2 in TORC1 regulation in Schizosaccharomyces pombe...