gcn5

Summary

Gene Symbol: gcn5
Description: SAGA complex histone acetyltransferase catalytic subunit Gcn5
Alias: kat2, SAGA complex histone acetyltransferase catalytic subunit Gcn5
Species: fission yeast

Top Publications

  1. Hirota K, Mizuno K, Shibata T, Ohta K. Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26. Mol Biol Cell. 2008;19:1162-73 pubmed publisher
    ..a cAMP-responsive element (CRE)-like sequence M26, the Atf1/Pcr1 heterodimeric ATF/CREB transcription factor, the Gcn5 HAT, and the Snf22 SWI2/SNF2 family ADCR...
  2. Johnsson A, Durand Dubief M, Xue Franzén Y, Rönnerblad M, Ekwall K, Wright A. HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress. EMBO Rep. 2009;10:1009-14 pubmed publisher
    Histone acetylation and deacetylation are important for gene regulation. The histone acetyltransferase, Gcn5, is an activator of transcriptional initiation that is recruited to gene promoters...
  3. Mitsuzawa H, Seino H, Yamao F, Ishihama A. Two WD repeat-containing TATA-binding protein-associated factors in fission yeast that suppress defects in the anaphase-promoting complex. J Biol Chem. 2001;276:17117-24 pubmed
    ..complex with TBP and other TAFs and that TAF72, but not TAF73, is associated with the putative histone acetylase Gcn5. We also show that overexpression of TAF72 or TAF73 suppresses the cell cycle arrest in mitosis caused by a ..
  4. Yamada T, Mizuno K, Hirota K, Kon N, Wahls W, Hartsuiker E, et al. Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J. 2004;23:1792-803 pubmed
    ..pombe homolog of Gcn5p, was required for the majority of histone H3 acetylation around M26 in vivo. Deletion of gcn5+ caused a significant delay in chromatin remodeling but only partial reduction of M26 meiotic recombination ..
  5. Helmlinger D, Marguerat S, Villen J, Gygi S, Bahler J, Winston F. The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8. Genes Dev. 2008;22:3184-95 pubmed publisher
    ..First, in nutrient-rich conditions, the SAGA histone acetyltransferase Gcn5 represses ste11(+), which encodes the master regulator of the mating pathway...
  6. Nugent R, Johnsson A, Fleharty B, Gogol M, Xue Franzén Y, Seidel C, et al. Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation. BMC Genomics. 2010;11:59 pubmed publisher
    ..Consistent with this, overlapping specificity in histone H3 acetylation is observed. However, there is no evidence for overlap with another HAT enzyme, encoded by the essential mst1+ gene. ..
  7. Sansó M, Vargas Pérez I, Quintales L, Antequera F, Ayte J, Hidalgo E. Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe. Nucleic Acids Res. 2011;39:6369-79 pubmed publisher
    ..In a genetic search, we have isolated the histone H3 acetyltransferase Gcn5, a component of the SAGA complex, as being essential for oxidative stress survival and activation of those genes...
  8. Wang Y, Kallgren S, Reddy B, Kuntz K, L pez Maury L, Thompson J, et al. Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast. J Biol Chem. 2012;287:4386-93 pubmed publisher
    ..Schizosaccharomyces pombe is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with Gcn5 to regulate global levels of H3K14 acetylation (H3K14ac)...
  9. Takahashi H, Sun X, Hamamoto M, Yashiroda Y, Yoshida M. The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast. J Biol Chem. 2012;287:38158-67 pubmed publisher
    ..Deletion of gcn5(+) increased leucine uptake in the prototrophic background and rendered the leucine auxotroph resistant to NH(4)Cl...

More Information

Publications15

  1. Creamer K, Job G, Shanker S, Neale G, Lin Y, Bartholomew B, et al. The Mi-2 homolog Mit1 actively positions nucleosomes within heterochromatin to suppress transcription. Mol Cell Biol. 2014;34:2046-61 pubmed publisher
    ..We propose that Mit1 is a chromatin remodeling factor that cooperates with the Clr3 histone deacetylase of SHREC and other chromatin modifiers to stabilize heterochromatin structure and to prevent access to the transcriptional machinery...
  2. Pai C, Deegan R, Subramanian L, Gal C, Sarkar S, Blaikley E, et al. A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice. Nat Commun. 2014;5:4091 pubmed publisher
    ..H3K36 methylation reduces chromatin accessibility, reduces resection and promotes NHEJ, while antagonistic Gcn5-dependent H3K36 acetylation increases chromatin accessibility, increases resection and promotes HR...
  3. Ringel A, Cieniewicz A, Taverna S, Wolberger C. Nucleosome competition reveals processive acetylation by the SAGA HAT module. Proc Natl Acad Sci U S A. 2015;112:E5461-70 pubmed publisher
    The Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator complex hyperacetylates histone tails in vivo in a manner that depends upon histone 3 lysine 4 trimethylation (H3K4me3), a histone mark enriched at promoters of actively transcribed ..
  4. Kiely C, Marguerat S, Garcia J, Madhani H, Bahler J, Winston F. Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. Mol Cell Biol. 2011;31:4193-204 pubmed publisher
    ..Taken together, our results suggest that Spt6 is required for multiple steps in heterochromatic silencing by controlling chromatin, transcriptional, and posttranscriptional processes. ..
  5. Toselli Mollereau E, Robellet X, Fauque L, Lemaire S, Schiklenk C, Klein C, et al. Nucleosome eviction in mitosis assists condensin loading and chromosome condensation. EMBO J. 2016;35:1565-81 pubmed publisher
    ..Two transcriptional coactivators, the Gcn5 histone acetyltransferase and the RSC chromatin-remodelling complex, bind to promoters adjoining condensin-binding ..
  6. Adachi A, Senmatsu S, Asada R, Abe T, Hoffman C, Ohta K, et al. Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast fbp1. Genes Genet Syst. 2018;92:267-276 pubmed publisher
    ..Here, we examine the roles played by two distinct ADCRs, Snf22 and Hrp3, and by the HAT Gcn5 in the transcriptional activation of fbp1...