dsc2

Summary

Gene Symbol: dsc2
Description: UBA domain protein Ucp14
Alias: ucp14, UBA domain protein Ucp14
Species: fission yeast

Top Publications

  1. Stewart E, LLOYD S, Burg J, Nwosu C, Lintner R, Daza R, et al. Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J Biol Chem. 2012;287:672-81 pubmed publisher
  2. LLOYD S, Raychaudhuri S, Espenshade P. Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem. 2013;288:21043-54 pubmed publisher
    ..b>Dsc2 is a rhomboid pseudoprotease family member homologous to mammalian UBAC2 and a central component of the Dsc E3 ..
  3. Cheung R, Espenshade P. Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem. 2013;288:20351-60 pubmed publisher
    ..These cleavage mutants will aid identification of the fungal SREBP protease and facilitate functional dissection of the Dsc E3 ligase required for SREBP activation and fungal pathogenesis...
  4. Raychaudhuri S, Espenshade P. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. J Biol Chem. 2015;290:14430-40 pubmed publisher
    ..These results define enzyme activity-dependent sorting as an autoregulatory mechanism for protein trafficking. ..
  5. Burr R, Stewart E, Espenshade P. Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors. J Biol Chem. 2017;292:5311-5324 pubmed publisher
    ..Together, these data demonstrate that Sre1 and Mga2 are each regulated by the lipid product of the other transcription factor pathway, providing a source of coordination for these two branches of lipid synthesis. ..

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