Gene Symbol: dph1
Description: UBA domain protein Dph1
Alias: ucp5, UBA domain protein Dph1
Species: fission yeast
Wilkinson C, Seeger M, Hartmann Petersen R, Stone M, Wallace M, Semple C, et al
. Proteins containing the UBA domain are able to bind to multi-ubiquitin chains. Nat Cell Biol. 2001;3:939-43 pubmed
..These two proteins are implicated, along with the fission-yeast Pus1(S5a/Rpn10) subunit of the 26 S proteasome, in the recognition and turnover of substrates by this proteolytic complex. ..
He X, Jones M, Winey M, Sazer S. Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe. J Cell Sci. 1998;111 ( Pt 12):1635-47 pubmed
..In the same screen which led to the isolation of mad2 and mph1, we also isolated dph1, a cDNA that encodes a protein 46% identical to an S. cerevisiae SPB duplication protein, Dsk2p...
Hartmann Petersen R, Semple C, Ponting C, Hendil K, Gordon C. UBA domain containing proteins in fission yeast. Int J Biochem Cell Biol. 2003;35:629-36 pubmed
..The proteins display remarkable differences in their domain organisation, indicating that these potential ubiquitin binding proteins are involved in various cell activities. ..
Hänzelmann P, Stingele J, Hofmann K, Schindelin H, Raasi S. The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain. J Biol Chem. 2010;285:20390-8 pubmed publisher
..The molecular details of their differential interactions point to a role for adaptive evolution in shaping these interfaces. ..
Paraskevopoulos K, Kriegenburg F, Tatham M, RÃ¶sner H, Medina B, Larsen I, et al
. Dss1 is a 26S proteasome ubiquitin receptor. Mol Cell. 2014;56:453-61 pubmed publisher
..Mutations in the ubiquitin-binding site of Dss1 cause growth defects and accumulation of ubiquitylated proteins. ..
Elder R, Song X, Chen M, Hopkins K, Lieberman H, Zhao Y. Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination. Nucleic Acids Res. 2002;30:581-91 pubmed
..Thus, the rhp23 gene plays a role not only in nucleotide excision repair but also in cell cycle regulation and the ubiquitination pathways. ..
Hartmann Petersen R, Hendil K, Gordon C. Ubiquitin binding proteins protect ubiquitin conjugates from disassembly. FEBS Lett. 2003;535:77-81 pubmed
..Here we report that three ubiquitin binding proteins, Rhp23, Dph1 and Pus1, from fission yeast can protect multiubiquitin conjugates against deubiquitination...
Martín García R, Mulvihill D. Myosin V spatially regulates microtubule dynamics and promotes the ubiquitin-dependent degradation of the fission yeast CLIP-170 homologue, Tip1. J Cell Sci. 2009;122:3862-72 pubmed publisher
..Myo52 facilitates microtubule catastrophe by enhancing Tip1 removal from the plus end of growing microtubules at the cell tips. There, Myo52 and the ubiquitin receptor, Dph1, work in concert to target Tip1 for degradation.