Gene Symbol: dma1
Description: mitotic spindle checkpoint protein Dma1
Alias: mitotic spindle checkpoint protein Dma1
Species: fission yeast
Guertin D, Venkatram S, Gould K, McCollum D. Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN). Dev Cell. 2002;3:779-90 pubmed
..Deletion of dma1 inactivates the spindle checkpoint and allows precocious SIN activation, while overexpressing Dma1p reduces SIN ..
Murone M, Simanis V. The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. EMBO J. 1996;15:6605-16 pubmed
..we have isolated multicopy suppressors of the cdc16-116 mutation, and the characterization of one of these, dma1 (defective in mitotic arrest), is presented here...
Salimova E, Sohrmann M, Fournier N, Simanis V. The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation. J Cell Sci. 2000;113 ( Pt 10):1695-704 pubmed
..We also demonstrate that mob1p can be precipitated from cells in a complex with the septation regulating kinase sid2p. ..
Krapp A, Del Rosario E, Simanis V. The role of Schizosaccharomyces pombe dma1 in spore formation during meiosis. J Cell Sci. 2010;123:3284-93 pubmed publisher
..Dma1p also contributes to the temporal regulation of the abundance of the meiosis-specific SIN component mug27p. ..
Johnson A, Gould K. Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase. EMBO J. 2011;30:341-54 pubmed publisher
..In the fission yeast, Schizosaccharomyces pombe, the checkpoint protein and E3 ubiquitin ligase, Dma1, delays cytokinesis by inhibiting the septation initiation network (SIN) when chromosomes are not attached to the ..
Fournier N, Cerutti L, Beltraminelli N, Salimova E, Simanis V. Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes. Arch Microbiol. 2001;175:62-9 pubmed
..We also demonstrate that increased expression of the dma1 gene can rescue the lethality of a null allele of cdc16...
Cullen C, May K, Hagan I, Glover D, Ohkura H. A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast. Genetics. 2000;155:1521-34 pubmed
..cdc16(+), dma1(+), byr3(+), byr4(+) and a truncated form of the cdc7 gene were isolated by complementation of one of these cdc16 ..
Chew T, Balasubramanian M. Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast. PLoS Genet. 2008;4:e17 pubmed publisher
..We propose that Nuc2p, by inhibiting the SIN after cell division, prevents further deleterious cytokinetic events, thereby contributing to genome stability. ..
Li W, Yu Z, Ma P, Wang Y, Jin Q. A novel role of Dma1 in regulating forespore membrane assembly and sporulation in fission yeast. Mol Biol Cell. 2010;21:4349-60 pubmed publisher
..We report here an unexpected function of mitotic spindle checkpoint protein Dma1 in proper spore formation...