Gene Symbol: cig2
Description: G1/S-specific B-type cyclin Cig2
Alias: cyc17, G1/S-specific B-type cyclin Cig2
Species: fission yeast

Top Publications

  1. Wu L, Russell P. Roles of Wee1 and Nim1 protein kinases in regulating the switch from mitotic division to sexual development in Schizosaccharomyces pombe. Mol Cell Biol. 1997;17:10-7 pubmed
    ..This process is dependent on Rum1, an inhibitor of the Cdc2-Cdc13 and Cdc2-Cig2 cyclin B kinases...
  2. Munier F, Perentes E, Herbort C, Uffer S, Biollaz J. Selective loss of optic nerve beta-tubulin in vincristine-induced blindness. Am J Med. 1992;93:232-4 pubmed
  3. Jallepalli P, Brown G, Muzi Falconi M, Tien D, Kelly T. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev. 1997;11:2767-79 pubmed
    ..Genetic interactions between cdc18+ and the S-phase cyclin cig2+ suggest that CDK-dependent phosphorylation antagonizes cdc18+ function in vivo...
  4. Snaith H, Forsburg S. Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes. Genetics. 1999;152:839-51 pubmed
    ..of the Cdc13p cyclin is essentially the same and requires the activity of two minor B-type cyclins, cig1(+) and cig2(+)...
  5. Gutiérrez Escribano P, Nurse P. A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast. Nat Commun. 2015;6:6871 pubmed publisher
    ..We propose that qualitatively different CDK complexes are not absolutely required for cell cycle progression either during mitosis or meiosis, and that a single CDK complex can drive both cell cycle programmes. ..
  6. Mondesert O, McGowan C, Russell P. Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol Cell Biol. 1996;16:1527-33 pubmed
    ..Two additional B-type cyclins, Cig1 and Cig2, have been identified in S. pombe, but none of the B-type cyclins are individually required for the onset of S...
  7. Malapeira J, Moldón A, Hidalgo E, Smith G, Nurse P, Ayte J. A meiosis-specific cyclin regulated by splicing is required for proper progression through meiosis. Mol Cell Biol. 2005;25:6330-7 pubmed
    ..Cells lacking Rem1 have impaired meiotic recombination, and Rem1 is required for premeiotic DNA synthesis when Cig2 is not present...
  8. Izawa D, Goto M, Yamashita A, Yamano H, Yamamoto M. Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p. Nature. 2005;434:529-33 pubmed
    ..We therefore propose that Mes1p has a key function in saving a sufficient level of MPF (M-phase-promoting factor) activity required for the execution of MII. ..
  9. Noguchi E, Shanahan P, Noguchi C, Russell P. CDK phosphorylation of Drc1 regulates DNA replication in fission yeast. Curr Biol. 2002;12:599-605 pubmed
    ..These data suggest that Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5. ..

More Information


  1. Yamano H, Kitamura K, Kominami K, Lehmann A, Katayama S, Hunt T, et al. The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases. Mol Cell. 2000;6:1377-87 pubmed
    We describe a novel set of oscillation mechanisms for the fission yeast S phase cyclin Cig2, which contains an authentic destruction box and is destroyed at anaphase via the APC/cyclosome (APC/C)...
  2. Grallert B, Kearsey S, Lenhard M, Carlson C, Nurse P, Boye E, et al. A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls. J Cell Sci. 2000;113 ( Pt 8):1447-58 pubmed
    ..Levels of the B-cyclins Cig2 and Cdc13 are dramatically reduced upon inactivation of Ded1, and this reduction is independent of degradation by ..
  3. Alves Rodrigues I, Ferreira P, Moldón A, Vivancos A, Hidalgo E, Guigó R, et al. Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program. Cell Rep. 2016;14:885-895 pubmed publisher
    ..During meiosis, Fkh2 is phosphorylated in a CDK/Cig2-dependent manner, decreasing its affinity for DNA, which creates a window of opportunity for Mei4 binding to its ..
  4. Kominami K, Seth Smith H, Toda T. Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast. EMBO J. 1998;17:5388-99 pubmed
    ..The results suggest that dual downregulation of CDK, one via the APC and the other via the CDK inhibitor, is a universal mechanism that is used to arrest cell cycle progression at G1. ..
  5. Stern B, Nurse P. Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast. Mol Biol Cell. 1998;9:1309-21 pubmed
    ..We have also shown that pheromone-induced transcription occurs only in G1 and is independent of rum1p. ..
  6. Bueno A, Russell P. Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis. Mol Cell Biol. 1993;13:2286-97 pubmed
    ..We report the discovery of cig2, a third B-type cyclin gene in Schizosaccharomyces pombe...
  7. Martín Castellanos C, Moreno S. Regulation of G1 progression in fission yeast by the rum1+ gene product. Prog Cell Cycle Res. 1996;2:29-35 pubmed
    ..b>cig2 is the major G1 cyclin while cdc13 is the principal mitotic cyclin...
  8. Caetano C, Limbo O, Farmer S, Klier S, Dovey C, Russell P, et al. Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability. Cell Rep. 2014;9:2279-89 pubmed publisher
    ..Surprisingly, the normally inconsequential MBF-regulated S-phase cyclin Cig2 also becomes essential in the absence of Nrm1...
  9. Yamada Y, Nakagawa T, Masukata H. A novel intermediate in initiation complex assembly for fission yeast DNA replication. Mol Biol Cell. 2004;15:3740-50 pubmed
    ..These results suggest that the complex containing MCM and Sld3 is an intermediate for initiation of DNA replication in fission yeast. ..
  10. Tanaka K, Yonekawa T, Kawasaki Y, Kai M, Furuya K, Iwasaki M, et al. Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase. Mol Cell Biol. 2000;20:3459-69 pubmed
    ..The C-terminal region acts to establish sister chromatid cohesion, and the N-terminal region presumably catalyzes translesion DNA synthesis when template DNA contains lesions that block regular DNA replication. ..
  11. Fisher D, Nurse P. A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. EMBO J. 1996;15:850-60 pubmed
    ..Further deletion of cig1 and puc1 had no effect, but deletion of cig2/cyc17 caused a severe delay in re-replication...
  12. Yamaguchi S, Murakami H, Okayama H. A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes. Mol Biol Cell. 1997;8:2475-86 pubmed
    ..Fertility is restored to the disruptant by deletion of Cig2 B-type cyclin or slight inactivation of p34(cdc2)...
  13. Yamano H, Kominami K, Harrison C, Kitamura K, Katayama S, Dhut S, et al. Requirement of the SCFPop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2. J Biol Chem. 2004;279:18974-80 pubmed
    ..Here we show that fission yeast S phase cyclin Cig2 is ubiquitylated and degraded via both the SCF and the APC/C...
  14. Obara Ishihara T, Okayama H. A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast. EMBO J. 1994;13:1863-72 pubmed
    ..This cyclin, named Cyc17, is highly homologous with Cdc13, but has no detectable activity as a mitotic cyclin...
  15. Maki K, Inoue T, Onaka A, Hashizume H, Somete N, Kobayashi Y, et al. Abundance of prereplicative complexes (Pre-RCs) facilitates recombinational repair under replication stress in fission yeast. J Biol Chem. 2011;286:41701-10 pubmed publisher
    ..Remarkably, G(1) phase extension through deletion of an S phase cyclin, Cig2, as well as Cdt1 overexpression restored pre-RC assembly and suppressed Rhp54 accumulation...
  16. Ayte J, Schweitzer C, Zarzov P, Nurse P, DeCaprio J. Feedback regulation of the MBF transcription factor by cyclin Cig2. Nat Cell Biol. 2001;3:1043-50 pubmed
    ..We report here that the cell-cycle-regulated expression of the cyclin cig2 gene is dependent on MBF...
  17. Martín Castellanos C, Blanco M, de Prada J, Moreno S. The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size. Mol Biol Cell. 2000;11:543-54 pubmed
    ..In fission yeast, the length of the G1 phase depends on a precise balance between levels of positive (cig1, cig2, puc1, and cdc13 cyclins) and negative (rum1 and ste9-APC) regulators of cdc2...
  18. Kitamura K, Maekawa H, Shimoda C. Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase. Mol Biol Cell. 1998;9:1065-80 pubmed
    ..Sterility was partially suppressed by the mutation in cig2 that encoded the major G1/S cyclin...
  19. Wuarin J, Buck V, Nurse P, Millar J. Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication. Cell. 2002;111:419-31 pubmed
    ..Thus, ORC bound mitotic Cyclin B/Cdc2 kinase imposes the dependency of S phase on an intervening mitosis but not the temporal licensing of replication origins between each S phase. ..
  20. Brown G, Jallepalli P, Huneycutt B, Kelly T. Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast. Proc Natl Acad Sci U S A. 1997;94:6142-7 pubmed
    ..These interactions between Cdc18 and cyclin-dependent kinases suggest mechanisms by which cyclin-dependent kinases could activate the initiation of DNA replication and could prevent rereplication. ..
  21. Santosa V, Martha S, Hirose N, Tanaka K. The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP), Mcb1, regulates MCM function during prereplicative complex formation in DNA replication. J Biol Chem. 2013;288:6864-80 pubmed publisher
    ..Moreover, cyclin-dependent kinase modulation by Cig2 repression or Rum1 overproduction suppressed the mcb1(ts) mutants, suggesting the involvement of Mcb1 in pre-RC ..
  22. Shimada M, Yamada Namikawa C, Murakami Tonami Y, Yoshida T, Nakanishi M, Urano T, et al. Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast. EMBO J. 2008;27:132-42 pubmed
    ..We propose that functional interaction between Cdks and forkhead transcription factors may link the mitotic cell cycle and sexual differentiation. ..
  23. Lopez Girona A, Mondesert O, Leatherwood J, Russell P. Negative regulation of Cdc18 DNA replication protein by Cdc2. Mol Biol Cell. 1998;9:63-73 pubmed
    ..Consistent with this hypothesis, we report that Cdc18 interacts with Cdc2 in association with Cdc13 and Cig2 B-type cyclins in vivo. Cdc18 is phosphorylated by the associated Cdc2 in vitro...
  24. Tanaka K, Okayama H. A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast. Mol Biol Cell. 2000;11:2845-62 pubmed