Gene Symbol: cid1
Description: poly(A) polymerase Cid1
Alias: poly(A) polymerase Cid1
Species: fission yeast
Munoz Tello P, Gabus C, Thore S. A critical switch in the enzymatic properties of the Cid1 protein deciphered from its product-bound crystal structure. Nucleic Acids Res. 2014;42:3372-80 pubmed publisher
..b>Cid1 protein is a member of the PUP family...
Wang S, Toda T, MacCallum R, Harris A, Norbury C. Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated. Mol Cell Biol. 2000;20:3234-44 pubmed
..We identified cid1, a novel fission yeast gene, through its ability when overexpressed to confer specific resistance to a combination ..
Rissland O, Mikulasova A, Norbury C. Efficient RNA polyuridylation by noncanonical poly(A) polymerases. Mol Cell Biol. 2007;27:3612-24 pubmed
..Here we characterize the biochemical activity of fission yeast Schizosaccharomyces pombe Cid1, a putative cytoplasmic PAP implicated in cell cycle checkpoint controls...
Rissland O, Norbury C. The Cid1 poly(U) polymerase. Biochim Biophys Acta. 2008;1779:286-94 pubmed publisher
The Schizosaccharomyces pombe cytoplasmic protein Cid1 acts as a poly(U) polymerase (PUP). Polyadenylated actin mRNA, a target of this activity, is uridylated upon arrest in S phase and is likely to be one of many such Cid1 targets...
Yates L, FleurdÃ©pine S, Rissland O, De Colibus L, Harlos K, Norbury C, et al
. Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase. Nat Struct Mol Biol. 2012;19:782-787 pubmed publisher
..Here we describe crystal structures of the Schizosaccharomyces pombe cytoplasmic terminal uridylyl transferase Cid1 in two apo conformers and bound to UTP...
Read R, Martinho R, Wang S, Carr A, Norbury C. Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Proc Natl Acad Sci U S A. 2002;99:12079-84 pubmed
..This inviability can be suppressed in fission yeast by overexpression of Cid1 or the related protein Cid13...
Rissland O, Norbury C. Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover. Nat Struct Mol Biol. 2009;16:616-23 pubmed publisher
..First, in fission yeast mRNA decapping is frequently independent of deadenylation. Second, Cid1-dependent uridylation of polyadenylated mRNAs, such as act1, hcn1 and urg1, seems to stimulate decapping as part of ..
Munoz Tello P, Gabus C, Thore S. Functional implications from the Cid1 poly(U) polymerase crystal structure. Structure. 2012;20:977-86 pubmed publisher
..We determined the atomic structure of the Cid1 protein, the founding member of the PUP family, in its UTP-bound form, allowing unambiguous positioning of the UTP ..
Lunde B, Magler I, Meinhart A. Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism for UTP selectivity. Nucleic Acids Res. 2012;40:9815-24 pubmed publisher
..We report the structures of poly (U) polymerase Cid1 from Schizoscaccharomyces pombe alone and in complex with UTP, CTP, GTP and 3'-dATP...