Gene Symbol: cdc48
Description: AAA family ATPase Cdc48
Alias: SPAC6F12.01, AAA family ATPase Cdc48
Species: fission yeast

Top Publications

  1. Hartmann Petersen R, Wallace M, Hofmann K, Koch G, Johnsen A, Hendil K, et al. The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes. Curr Biol. 2004;14:824-8 pubmed
    Valosin-containing protein, VCP/p97 or Cdc48, is a eukaryotic ATPase involved in membrane fusion, protein transport, and protein degradation. We describe two proteins, Ubx2 and Ubx3, which interact with Cdc48 in fission yeast...
  2. Ikai N, Yanagida M. Cdc48 is required for the stability of Cut1/separase in mitotic anaphase. J Struct Biol. 2006;156:50-61 pubmed
    ..b>Cdc48/VCP/p97, an AAA ATPase, is involved in a variety of cellular activities, many of which are implicated in the ..
  3. Køhler J, Jørgensen M, Beinoraité G, Thorsen M, Thon G. Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response. PLoS ONE. 2013;8:e80442 pubmed publisher
    ..Ufd1 is a subunit of the Cdc48-Ufd1-Npl4 complex implicated in the sorting of ubiquitylated substrates for degradation by the proteasome...
  4. Stewart E, LLOYD S, Burg J, Nwosu C, Lintner R, Daza R, et al. Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J Biol Chem. 2012;287:672-81 pubmed publisher
    ..From the selection, we identified two new components of the fission yeast SREBP pathway: Dsc5 and Cdc48. The AAA (ATPase associated with diverse cellular activities) ATPase Cdc48 and Dsc5, a ubiquitin regulatory X ..
  5. Nie M, Aslanian A, Prudden J, Heideker J, Vashisht A, Wohlschlegel J, et al. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. J Biol Chem. 2012;287:29610-9 pubmed publisher
    ..Herein, we determine that the "ubiquitin-selective" segregase Cdc48-Ufd1-Npl4 also binds SUMO via a SUMO interaction motif in Ufd1 and can thus act as a selective receptor for STUbL ..
  6. Vjestica A, Tang X, Oliferenko S. The actomyosin ring recruits early secretory compartments to the division site in fission yeast. Mol Biol Cell. 2008;19:1125-38 pubmed publisher
    ..Cdc15p overexpression was sufficient to induce tER polarization in interphase. Thus, fission yeast polarizes its entire secretory machinery to the cell division site by utilizing molecular cues provided by the actomyosin ring. ..
  7. Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, et al. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. EMBO J. 2016;35:2332-2349 pubmed
    ..Using APEX2 proximity biotinylation, we demonstrated that Rbd2 binds the AAA-ATPase Cdc48 through a C-terminal SHP box...
  8. Cheeseman I, Desai A. Cell division: AAAtacking the mitotic spindle. Curr Biol. 2004;14:R70-2 pubmed
    ..But how is this spindle broken down once chromosome segregation is complete? New evidence implicates a highly conserved AAA-ATPase in spindle disassembly at the end of mitosis. ..
  9. Otero J, Suo J, Gordon C, Chang E. Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation. Cell Cycle. 2010;9:147-61 pubmed
    ..In the present study, we isolated Cdc48 as a Moe1-binding protein from a yeast two-hybrid screen, and confirmed biochemically that they form a stable ..

More Information


  1. Deng L, Kabeche R, Wang N, Wu J, Moseley J. Megadalton-node assembly by binding of Skb1 to the membrane anchor Slf1. Mol Biol Cell. 2014;25:2660-8 pubmed publisher
    ..We propose a mechanism for higher-order node formation by Skb1 and Slf1, with implications for macromolecular assemblies in diverse cell types. ..
  2. Marinova I, Engelbrecht J, Ewald A, Langholm L, Holmberg C, Kragelund B, et al. Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing. PLoS ONE. 2015;10:e0117779 pubmed publisher
    The protein called p97 in mammals and Cdc48 in budding and fission yeast is a homo-hexameric, ring-shaped, ubiquitin-dependent ATPase complex involved in a range of cellular functions, including protein degradation, vesicle fusion, DNA ..
  3. Lucena R, Dephoure N, Gygi S, Kellogg D, Tallada V, Daga R, et al. Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly. J Cell Biol. 2015;209:387-402 pubmed publisher
    ..We show that, during anaphase B, Imp1-mediated transport of the AAA-ATPase Cdc48 protein at the MMD allows this disassembly factor to localize at the spindle midzone, thereby promoting spindle ..
  4. Burr R, Ribbens D, Raychaudhuri S, Stewart E, Ho J, Espenshade P. Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast. J Biol Chem. 2017;292:16333-16350 pubmed publisher
    ..protease Rbd2, and the essential ATPases associated with diverse cellular activities (AAA+) ATPase Cdc48. The soluble SREBP N-terminal transcription factor domain is then released into the cytosol to enter the nucleus ..
  5. Cheung R, Espenshade P. Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem. 2013;288:20351-60 pubmed publisher
    ..These cleavage mutants will aid identification of the fungal SREBP protease and facilitate functional dissection of the Dsc E3 ligase required for SREBP activation and fungal pathogenesis...
  6. Hwang J, Espenshade P. Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2. Biochem J. 2016;473:2463-9 pubmed publisher
    ..The methods described herein set the stage for large-scale proteomic studies in yeast. With modifications, the method is also expected to be effective in other organisms with cell walls, such as bacteria and plants. ..
  7. Ogiso Y, Sugiura R, Kamo T, Yanagiya S, Lu Y, Okazaki K, et al. Lub1 participates in ubiquitin homeostasis and stress response via maintenance of cellular ubiquitin contents in fission yeast. Mol Cell Biol. 2004;24:2324-31 pubmed
    ..Also Cdc48, a stress-induced chaperon-like essential ATPase, was found to interact with Lub1, and this association might ..