cdc13

Summary

Gene Symbol: cdc13
Description: G2/M B-type cyclin Cdc13
Alias: G2/M B-type cyclin Cdc13
Species: fission yeast

Top Publications

  1. Forsburg S, Nurse P. Identification of a G1-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe. Nature. 1991;351:245-8 pubmed
    ..pombe, using a functional assay in S. cerevisiae. Expression of puc1+ in S. pombe indicates that it has a cyclin-like role in the fission yeast distinct from the role of the B-type mitotic cyclin. ..
  2. Bueno A, Richardson H, Reed S, Russell P. A fission yeast B-type cyclin functioning early in the cell cycle. Cell. 1991;66:149-59 pubmed
    ..cerevisiae strain lacking CLN Start cyclins. Thus, cig1+ identifies a new class of B-type cyclin acting in G1 or S phase that appears to be functionally distinct from all previously described cyclin proteins. ..
  3. Leatherwood J, Lopez Girona A, Russell P. Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature. 1996;379:360-3 pubmed
    ..These findings suggest that ORC functions are conserved among eukaryotes and provide evidence that Cdc2 controls DNA replication initiation by acting directly at chromosomal origins. ..
  4. Tasto J, Carnahan R, McDonald W, Gould K. Vectors and gene targeting modules for tandem affinity purification in Schizosaccharomyces pombe. Yeast. 2001;18:657-62 pubmed
    ..Several known binding proteins co-purified with both Cdc2p-CTAP and N-TAP-Cdc2p, indicating the usefulness of these tags for the rapid purification of stable protein complexes from Sz. pombe. ..
  5. Decottignies A, Zarzov P, Nurse P. In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis. J Cell Sci. 2001;114:2627-40 pubmed
    ..Nuclear cdc2-YFP fluorescence oscillates with that of cdc13-YFP cyclin...
  6. Caspari T, Murray J, Carr A. Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. Genes Dev. 2002;16:1195-208 pubmed
    ..Our data suggest a model in which CDK activity links processing of recombination intermediates to cell cycle progression via checkpoint proteins. ..
  7. Yamano H, Gannon J, Hunt T. The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe. EMBO J. 1996;15:5268-79 pubmed
    ..from Xenopus eggs was used to identify the 'destruction box' of the Schizosaccharomyces pombe B-type cyclin, Cdc13, as residues 59-67: RHALDDVSN. Expression of indestructible Cdc13 from a regulated promoter in S...
  8. Chang L, Morrell J, Feoktistova A, Gould K. Study of cyclin proteolysis in anaphase-promoting complex (APC) mutant cells reveals the requirement for APC function in the final steps of the fission yeast septation initiation network. Mol Cell Biol. 2001;21:6681-94 pubmed
    ..In contrast to this prediction, we show that Cdc2p kinase activity fluctuates in APC cut mutants due to Cdc13/cyclin B destruction. In APC-null mutants, however, septation and cutting do not occur and Cdc13p is stable...
  9. Blanco M, Pelloquin L, Moreno S. Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation. J Cell Sci. 2001;114:2135-43 pubmed
    ..mfr1 is an activator of the anaphase-promoting complex (APC), which is necessary for the rapid degradation of the cdc13 cyclin at the end of meiosis II, prior to the formation of spores...

More Information

Publications69

  1. Morrell J, Tomlin G, Rajagopalan S, Venkatram S, Feoktistova A, Tasto J, et al. Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB. Curr Biol. 2004;14:579-84 pubmed
    ..Our results suggest that the Sid4p-Cdc11p complex organizes a signaling hub on the SPB and that this hub coordinates cell and nuclear division. ..
  2. Izawa D, Goto M, Yamashita A, Yamano H, Yamamoto M. Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p. Nature. 2005;434:529-33 pubmed
    ..We therefore propose that Mes1p has a key function in saving a sufficient level of MPF (M-phase-promoting factor) activity required for the execution of MII. ..
  3. Yamano H, Tsurumi C, Gannon J, Hunt T. The role of the destruction box and its neighbouring lysine residues in cyclin B for anaphase ubiquitin-dependent proteolysis in fission yeast: defining the D-box receptor. EMBO J. 1998;17:5670-8 pubmed
    ..Strong expression of protein fragments containing destruction boxes, such as the first 70 residues of Cdc13 (N70), inhibits the growth of Schizosaccharomyces pombe at metaphase...
  4. Sajiki K, Hatanaka M, Nakamura T, Takeda K, Shimanuki M, Yoshida T, et al. Genetic control of cellular quiescence in S. pombe. J Cell Sci. 2009;122:1418-29 pubmed publisher
    ..We propose that the transcriptional role of Fcp1 is central in differentiating quiescence from proliferation. ..
  5. da Fonseca P, Kong E, Zhang Z, Schreiber A, Williams M, Morris E, et al. Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature. 2011;470:274-8 pubmed publisher
    ..Our results rationalize the contribution of both co-activator and core APC/C subunits to D-box recognition and provide a structural framework for understanding mechanisms of substrate recognition and catalysis by the APC/C. ..
  6. Fisher D, Nurse P. A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. EMBO J. 1996;15:850-60 pubmed
    Deletion of the fission yeast mitotic B-type cyclin gene cdc13 causes cells to undergo successive rounds of DNA replication. We have used a strain which expresses cdc13 conditionally to investigate re-replication...
  7. Sakai T. Cdk inhibitor ste9p/srw1p is involved in response to protein synthesis inhibition in fission yeast. Biochem Biophys Res Commun. 2004;315:984-90 pubmed
    ..It is suggested that cell cycle be positively controlled in an ste9-dependent manner before essential factors for viability and other important functions are exhausted when protein synthesis is inhibited. ..
  8. Grallert B, Sipiczki M. Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe. Curr Genet. 1991;20:199-204 pubmed
    ..Mutants defective in the mitotic initiation genes cdc2, cdc25 and cdc13 were blocked in meiosis II. None of the wee1-50, adh...
  9. Sveiczer A, Tyson J, Novak B. Modelling the fission yeast cell cycle. Brief Funct Genomic Proteomic. 2004;2:298-307 pubmed
    ..rounds of DNA synthesis (endoreplication) in fission yeast cells that lack the main (B-type) mitotic cyclin, Cdc13. It is proposed that the key physiological variable driving progression through the cell cycle during balanced ..
  10. Hagan I, Hayles J, Nurse P. Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis. J Cell Sci. 1988;91 ( Pt 4):587-95 pubmed
    We have cloned and sequenced the cdc13+ gene from fission yeast...
  11. Rajagopalan S, Mishra M, Balasubramanian M. Schizosaccharomyces pombe homolog of Survivin, Bir1p, exhibits a novel dynamic behavior at the spindle mid-zone. Genes Cells. 2006;11:815-27 pubmed
    ..Thus, Bir1p, and possibly its associated proteins, might organize a dynamic mid-zone region that helps spindle elongation and maintenance. ..
  12. Nurse P, Thuriaux P, Nasmyth K. Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet. 1976;146:167-78 pubmed
    ..Cell plate formation itself is usually dependent upon the completion of nuclear division. ..
  13. Rachfall N, Johnson A, Mehta S, Chen J, Gould K. Cdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network. Mol Biol Cell. 2014;25:2250-9 pubmed publisher
  14. Lin S, Wardlaw C, Morishita T, Miyabe I, Chahwan C, Caspari T, et al. The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner. PLoS Genet. 2012;8:e1002801 pubmed publisher
    ..We propose that AAD-dependent Rad3(ATR) checkpoint amplification is particularly important when DNA resection is limiting. In S. pombe, this manifests in G1/S phase and relies on protein-chromatin interactions. ..
  15. Correa Bordes J, Gulli M, Nurse P. p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle. EMBO J. 1997;16:4657-64 pubmed
    ..As a consequence, at this point in the cell cycle p56cdc13 proteolysis is inhibited, leading to a rise of p56cdc13 levels in preparation for mitosis. ..
  16. Feilotter H, Nurse P, Young P. Genetic and molecular analysis of cdr1/nim1 in Schizosaccharomyces pombe. Genetics. 1991;127:309-18 pubmed
    ..of the genetic interaction of cdr1 mutants with various mutants of mitotic control genes (cdc2, cdc25, wee1, cdc13) demonstrated strong interactions with cdc25, some cdc2 alleles, and with cdc13-117...
  17. Bueno A, Russell P. Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis. Mol Cell Biol. 1993;13:2286-97 pubmed
    ..Mitotic phenotypes caused by disruption of cig2 are not reversed by increased production of Cdc13, the other fission yeast B-type cyclin that functions in mitosis...
  18. Audit M, Barbier M, Soyer Gobillard M, Albert M, Geraud M, Nicolas G, et al. Cyclin B (p56cdc13) localization in the yeast Schizosaccharomyces pombe: an ultrastructural and immunocytochemical study. Biol Cell. 1996;86:1-10 pubmed
    ..In the fission yeast Schizosaccharomyces pombe, only one cyclin, the product of the cdc13 gene (p56cdc13), is required to be associated with p34cdc2, to control the complete cell cycle...
  19. Bandyopadhyay S, Dey I, Suresh M, Sundaram G. The basic leucine zipper domain transcription factor Atf1 directly controls Cdc13 expression and regulates mitotic entry independently of Wee1 and Cdc25 in Schizosaccharomyces pombe. Eukaryot Cell. 2014;13:813-21 pubmed publisher
    ..We show that the mitogen-activated protein kinase (MAPK)-regulated transcription factor Atf1 is a regulator of Cdc13 (mitotic cyclin) transcription and is therefore a prominent player in the regulation of mitosis in S. pombe...
  20. Kimata Y, Kitamura K, Fenner N, Yamano H. Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast. Mol Biol Cell. 2011;22:1486-94 pubmed publisher
    ..Thus Mes1 interacts with two coactivators in a different way to control the activity of the APC/C required for the meiosis I/meiosis II transition...
  21. Wuarin J, Buck V, Nurse P, Millar J. Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication. Cell. 2002;111:419-31 pubmed
    We show that in fission yeast the mitotic B type cyclin Cdc13/Cdc2 kinase associates with replication origins in vivo...
  22. Kominami K, Toda T. Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18. Genes Dev. 1997;11:1548-60 pubmed
    ..One operates through the Cdc2/Cdc13 kinase, which also involves the CDK inhibitor Rum1, and the other through the S-phase regulator Cdc18...
  23. Gould K, Feoktistova A, Fleig U. A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition. Mol Gen Genet. 1998;259:437-48 pubmed
    ..Multicopy suppressors of the dominant negative phenotype were isolated, and identified as cdc13+ and suc1+...
  24. Saka Y, Fantes P, Sutani T, McInerny C, Creanor J, Yanagida M. Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control. EMBO J. 1994;13:5319-29 pubmed
    ..Expression of the cut5 mutant phenotype requires the function of the M phase regulator genes cdc2+, cdc25+ and cdc13+...
  25. Yen H, Gordon C, Chang E. Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome. Cell. 2003;112:207-17 pubmed
    ..inactivation weakens and causes the accumulation of polyubiquitinated proteins including securin/Cut2 and cyclin/Cdc13. Yin6 regulates the proteasome by preferentially interacting with Rpn5, a conserved proteasome subunit, and ..
  26. Arata M, Sato M, Yamashita A, Yamamoto M. The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast. Genes Cells. 2014;19:225-38 pubmed publisher
    ..Using fluorescence microscopy to visualize YFP-tagged protein, we found that spo5 mutant cells precociously lost Cdc13, the major B-type cyclin in fission yeast, before meiosis II...
  27. Turnbull E, Martin I, Fantes P. Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe. J Cell Sci. 2006;119:292-302 pubmed
    ..Inactivation of Cdc2 appears to result from the inability to form complexes with its mitotic cyclin partner Cdc13. Further evidence for Cdc2 being a client of Cdc37 in S...
  28. Shimada M, Namikawa Yamada C, Nakanishi M, Murakami H. Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. J Biol Chem. 2005;280:32640-8 pubmed
    ..The abundance of Cdc13p was reduced, and the phosphorylation of Cdc2p on tyrosine 15 was maintained in splicing-defective cells. These results suggest that regulation of Cdc13p and Cdc2p is required for G2 arrest in splicing mutants. ..
  29. Caspari T, Hilditch V. Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe. PLoS ONE. 2015;10:e0130748 pubmed publisher
    ..While five forms are phosphorylated, two species are not. Four phospho-forms associate with cyclin B (Cdc13) of which only two are modified at Y15 by Wee1...
  30. Yamaguchi S, Murakami H, Okayama H. A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes. Mol Biol Cell. 1997;8:2475-86 pubmed
    ..they fail to effectively arrest in G1 and die of accelerated mitotic catastrophe if regulation of p34(cdc2)/Cdc13 by inhibitory tyrosine phosphorylation is compromised by partial inactivation of Wee1 kinase...
  31. Brown G, Jallepalli P, Huneycutt B, Kelly T. Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast. Proc Natl Acad Sci U S A. 1997;94:6142-7 pubmed
    ..These interactions between Cdc18 and cyclin-dependent kinases suggest mechanisms by which cyclin-dependent kinases could activate the initiation of DNA replication and could prevent rereplication. ..
  32. Tsukahara T, Tanno Y, Watanabe Y. Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. Nature. 2010;467:719-23 pubmed publisher
    ..In human cells, the phosphorylation of Borealin has a comparable role. Thus, our study resolves the conserved mechanisms of CPC targeting to centromeres, highlighting a key role of Cdk1-cyclin B in chromosome bi-orientation. ..
  33. Shimada M, Yamada Namikawa C, Murakami Tonami Y, Yoshida T, Nakanishi M, Urano T, et al. Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast. EMBO J. 2008;27:132-42 pubmed
    ..We propose that functional interaction between Cdks and forkhead transcription factors may link the mitotic cell cycle and sexual differentiation. ..
  34. Breeding C, Hudson J, Balasubramanian M, Hemmingsen S, Young P, Gould K. The cdr2(+) gene encodes a regulator of G2/M progression and cytokinesis in Schizosaccharomyces pombe. Mol Biol Cell. 1998;9:3399-415 pubmed
    ..Defects in cytokinesis are also generated by the overproduction of Cdr2p, but these defects are independent of wee1(+), suggesting that cdr2(+) encodes a second activity involved in cytokinesis...
  35. McCollum D, Balasubramanian M, Gould K. Identification of cold-sensitive mutations in the Schizosaccharomyces pombe actin locus. FEBS Lett. 1999;451:321-6 pubmed
    ..pombe. ..
  36. Mondesert O, McGowan C, Russell P. Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol Cell Biol. 1996;16:1527-33 pubmed
    ..b>Cdc13, a B-type cyclin, is required for the M-phase induction function of Cd2...
  37. Noguchi E, Shanahan P, Noguchi C, Russell P. CDK phosphorylation of Drc1 regulates DNA replication in fission yeast. Curr Biol. 2002;12:599-605 pubmed
    ..These data suggest that Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5. ..
  38. Booher R, Alfa C, Hyams J, Beach D. The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization. Cell. 1989;58:485-97 pubmed
    The products of the cdc13+ and cdc2+ genes form a stable complex that displays protein kinase activity in vitro. p63cdc13 is a substrate of p34cdc2, the catalytic subunit of the kinase...
  39. Rowley R, Zhang J. Caffeine-mediated override of checkpoint controls. A requirement for rhp6 (Schizosaccharomyces pombe). Genetics. 1999;152:61-71 pubmed
    ..deletion mutations show synthetic lethality at room temperature with temperature-sensitive mutations in cyclin B (cdc13-117) or the phosphatase cdc25 (cdc25-22)...
  40. Rhind N, Russell P. Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe. Mol Cell Biol. 1998;18:3782-7 pubmed
  41. Qu M, Rappas M, Wardlaw C, Garcia V, Ren J, Day M, et al. Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1). Mol Cell. 2013;51:723-736 pubmed publisher
    ..Finally, we show that the simultaneous interaction of a single Rad4(TopBP1) molecule with both Thr187 phosphorylation sites in a Crb2(53BP1) dimer is essential for establishing the DNA damage checkpoint. ..
  42. Fu C, Ward J, Loiodice I, Velve Casquillas G, Nedelec F, Tran P. Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation. Dev Cell. 2009;17:257-67 pubmed publisher
  43. Snaith H, Forsburg S. Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes. Genetics. 1999;152:839-51 pubmed
    ..Thus rereplication in fission yeast mimics the DNA synthesis of normal S phase, and the inability to rereplicate provides an excellent assay for novel S-phase mutants. ..
  44. Ren L, Feoktistova A, McDonald W, Haese G, Morrell J, Gould K. Analysis of the role of phosphorylation in fission yeast Cdc13p/cyclinB function. J Biol Chem. 2005;280:14591-6 pubmed
    ..Our data indicate that Cdc13p accumulates in the nucleolus in response to G(2) checkpoint delays, rather than in the cytoplasm, and that phosphorylation plays no role in Cdc13p localization or function. ..
  45. Moreno S, Hayles J, Nurse P. Regulation of p34cdc2 protein kinase during mitosis. Cell. 1989;58:361-72 pubmed
    ..Therefore, the cdc25+, cdc13+, and suc1+ gene products are important for regulating p34cdc2 protein kinase activity during entry into, progress ..
  46. Fleig U, Gould K, Nurse P. A dominant negative allele of p34cdc2 shows altered phosphoamino acid content and sequesters p56cdc13 cyclin. Mol Cell Biol. 1992;12:2295-301 pubmed
    ..Multicopy suppressors of the dominant negative phenotype have been isolated, and one of these has been shown to encode the cdc13 cyclin B gene product.
  47. Booher R, Beach D. Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules. EMBO J. 1988;7:2321-7 pubmed
    Previous genetic studies have shown that the fission yeast cdc13+ gene product interacts closely with the cdc2+ protein kinase during mitosis. Here, we have cloned the cdc13+ gene from a S...
  48. Booher R, Beach D. Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase. EMBO J. 1987;6:3441-7 pubmed
    ..This suppressor mutation was shown to be an allele of cdc13, a previously identified gene. A variety of allele-specific interactions between cdc2 and cdc13 were discovered...
  49. Bauer F, Matsuyama A, Candiracci J, Dieu M, Scheliga J, Wolf D, et al. Translational control of cell division by Elongator. Cell Rep. 2012;1:424-33 pubmed
    ..These findings uncover a mechanism by which the codon usage, coupled to tRNA modifications, fundamentally contributes to gene expression and cellular functions. ..
  50. Moiseeva V, Amelina H, Collopy L, Armstrong C, Pearson S, Tomita K. The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast. Cell Discov. 2017;3:17041 pubmed publisher
    ..Our findings illustrate that chromosome contact with the nuclear membrane synchronises meiotic progression of the nucleoplasmic chromosomes with that of the cytoplasmic SPB. ..
  51. Choi S, McCollum D. A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments. Curr Biol. 2012;22:225-30 pubmed publisher
  52. Tatebe H, Yanagida M. Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2. Curr Biol. 2000;10:1329-38 pubmed
    ..that destruction of mitotic cyclin and Cut2 in the nucleus is dramatically delayed, though polyubiquitination of Cdc13 occurs in cut8 mutant...
  53. Munoz M, Bejarano E, Daga R, Jimenez J. The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts. Genetics. 1999;153:1561-72 pubmed
  54. Alfa C, Booher R, Beach D, Hyams J. Fission yeast cyclin: subcellular localisation and cell cycle regulation. J Cell Sci Suppl. 1989;12:9-19 pubmed
    ..One of these, cdc13+, encodes a protein with homology to cyclin...
  55. Molz L, Booher R, Young P, Beach D. cdc2 and the regulation of mitosis: six interacting mcs genes. Genetics. 1989;122:773-82 pubmed
    ..mitotic catastrophe suppressor) that are not allelic to any of the following mitotic control genes: cdc2, wee 1, cdc13, cdc25, suc1 or nim1...
  56. Obara Ishihara T, Okayama H. A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast. EMBO J. 1994;13:1863-72 pubmed
    ..This cyclin, named Cyc17, is highly homologous with Cdc13, but has no detectable activity as a mitotic cyclin...
  57. Moris N, Shrivastava J, Jeffery L, Li J, Hayles J, Nurse P. A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast. Cell Cycle. 2016;15:3121-3130 pubmed
    ..The genes identified here are all conserved in human cells, suggesting that this dataset will be useful as a basis for further studies to identify rate-limiting steps for progression through the cell cycle in other eukaryotes. ..
  58. Liu H, Nefsky B, Walworth N. The Ded1 DEAD box helicase interacts with Chk1 and Cdc2. J Biol Chem. 2002;277:2637-43 pubmed
    ..These two stressors appear to cause different modifications. Thus, the Ded1 protein appears to respond to particular types of cellular stress and may influence the activity of Cdc2 as a result. ..
  59. Lopez Girona A, Mondesert O, Leatherwood J, Russell P. Negative regulation of Cdc18 DNA replication protein by Cdc2. Mol Biol Cell. 1998;9:63-73 pubmed
    ..Cdc18 overexpression induces DNA rereplication without mitosis, as does elimination of Cdc2-Cdc13 kinase during G2 phase...
  60. Bandyopadhyay S, Ghosh P, Basu S, Paul M, Alam S, Das E, et al. Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition. FEMS Microbiol Lett. 2017;364: pubmed publisher
    ..Here we present evidence in favour of selective inhibition of Atf1's ability to activate cdc13+ transcription...