Gene Symbol: brc1
Description: BRCT domain protein Brc1
Alias: BRCT domain protein Brc1
Species: fission yeast

Top Publications

  1. Pebernard S, McDonald W, Pavlova Y, Yates J, Boddy M. Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis. Mol Biol Cell. 2004;15:4866-76 pubmed
    ..Spore viability is reduced by nse2-1 and nse3-1, without affecting interhomolog recombination. Finally, genetic interactions shared by the nse mutants suggest that the Smc5+6 complex is important for replication fork stability. ..
  2. Sheedy D, Dimitrova D, Rankin J, Bass K, Lee K, Tapia Alveal C, et al. Brc1-mediated DNA repair and damage tolerance. Genetics. 2005;171:457-68 pubmed
    ..the Smc6 subunit, rad18-74 (renamed smc6-74), is suppressed by mild overexpression of a six-BRCT-domain protein, Brc1. Deletion of brc1 does not result in a hypersensitivity to UV-C or IR, and thus the function of Brc1 relative to ..
  3. Williams J, Williams R, Dovey C, Guenther G, Tainer J, Russell P. gammaH2A binds Brc1 to maintain genome integrity during S-phase. EMBO J. 2010;29:1136-48 pubmed publisher
    ..biochemical, small angle X-ray scattering (SAXS), and X-ray structural studies of the Schizosaccharomyces pombe Brc1, a 6-BRCT-domain protein that is structurally related to Saccharomyces cerevisiae Rtt107 and mammalian PTIP...
  4. Verkade H, Bugg S, Lindsay H, Carr A, O Connell M. Rad18 is required for DNA repair and checkpoint responses in fission yeast. Mol Biol Cell. 1999;10:2905-18 pubmed
    ..A gene encoding a BRCT-containing protein, brc1, was isolated as an allele-specific high-copy suppressor of rad18-74...
  5. Yadav R, Jablonowski C, Fernandez A, Lowe B, Henry R, Finkelstein D, et al. Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe. elife. 2017;6: pubmed publisher
    ..This analysis of H3-G34R mutant fission yeast provides mechanistic insight into how G34R mutation may promote genomic instability in glioma. ..
  6. Morikawa H, Morishita T, Kawane S, Iwasaki H, Carr A, Shinagawa H. Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast. Mol Cell Biol. 2004;24:9401-13 pubmed
    ..rad62 is essential for viability and genetically interacts with rad60, smc6, and brc1. Rad62 protein physically associates with the Smc5-6 complex...
  7. Lee K, Nizza S, Hayes T, Bass K, Irmisch A, Murray J, et al. Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function. Genetics. 2007;175:1585-95 pubmed
    ..A particular allele of smc6 (smc6-74) is suppressed by overexpression of Brc1, a six-BRCT domain protein that is required for DNA repair during S-phase...
  8. Rozenzhak S, Mejía Ramírez E, Williams J, Schaffer L, Hammond J, Head S, et al. Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast. PLoS Genet. 2010;6:e1001032 pubmed publisher
    ..histone H2A (gammaH2A), a Rad3 substrate that establishes a chromatin-based recruitment platform for Crb2 and Brc1 DNA repair/checkpoint proteins...
  9. Bass K, Murray J, O Connell M. Brc1-dependent recovery from replication stress. J Cell Sci. 2012;125:2753-64 pubmed publisher
    BRCT-containing protein 1 (Brc1) is a multi-BRCT (BRCA1 carboxyl terminus) domain protein in Schizosaccharomyces pombe that is required for resistance to chronic replicative stress, but whether this reflects a repair or replication defect ..

More Information


  1. S nchez A, Sharma S, Rozenzhak S, Roguev A, Krogan N, Chabes A, et al. Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant. Mol Cell Biol. 2012;32:4445-54 pubmed publisher
    ..requirements for proteins involved in recovery from replication fork collapse, including the ?H2AX-binding protein Brc1 and Mus81 Holliday junction resolvase...
  2. Zabrady K, Adamus M, Vondrova L, Liao C, Skoupilova H, Novakova M, et al. Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA. Nucleic Acids Res. 2016;44:1064-79 pubmed publisher
    ..Based on our results, we propose a model for loading of the SMC5/6 complex onto the chromatin. ..
  3. Sánchez A, Russell P. Ku stabilizes replication forks in the absence of Brc1. PLoS ONE. 2015;10:e0126598 pubmed publisher
    ..In the fission yeast Schizosaccharomyces pombe, the DNA damage response protein Brc1 binds phospho-histone H2A (γH2A)-marked chromatin during S-phase, but how Brc1 protects genome integrity remains ..
  4. Cavero S, Limbo O, Russell P. Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast. PLoS Genet. 2010;6:e1001138 pubmed publisher
    ..From these studies we propose that Ssb3 plays a critical role in mediating RPA functions that are required for repair or tolerance of DNA lesions in S-phase. Rpa3 orthologs in humans and other species may have a similar function. ..
  5. Schonbrun M, Kolesnikov M, Kupiec M, Weisman R. TORC2 is required to maintain genome stability during S phase in fission yeast. J Biol Chem. 2013;288:19649-60 pubmed publisher
    ..Our findings indicate that TORC2 is required for genome integrity. This may be relevant for the growing amount of evidence implicating TORC2 in cancer development...
  6. Lee S, Rozenzhak S, Russell P. ?H2A-binding protein Brc1 affects centromere function in fission yeast. Mol Cell Biol. 2013;33:1410-6 pubmed publisher
    ..histone H2A on serine-128/-129 to create ?H2A in pericentromeric heterochromatin during S phase, which recruits Brc1 through its breast cancer gene 1 protein (BRCA1) C-terminal (BRCT) domains...
  7. Outwin E, Irmisch A, Murray J, O Connell M. Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes. Mol Cell Biol. 2009;29:4363-75 pubmed publisher
    ..In both cases, Separase overexpression bypasses the defect and restores cell viability, showing that defective cohesin removal is a major determinant of the mitotic lethality of Smc5-Smc6 mutants. ..
  8. Reubens M, Rozenzhak S, Russell P. Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and ?H2A To Maintain Genome Stability during S Phase. Mol Cell Biol. 2017;37: pubmed publisher
    ..In the fission yeast Schizosaccharomyces pombe, the multi-BRCT domain protein Brc1, which is related to budding yeast Rtt107 and mammalian PTIP, plays an important role in maintaining ..