Gene Symbol: atf1
Description: Atf-CREB family transcription factor Atf1
Alias: gad7, mts1, sss1, Atf-CREB family transcription factor Atf1
Species: fission yeast

Top Publications

  1. Ors A, Grimaldi M, Kimata Y, Wilkinson C, Jones N, Yamano H. The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast. J Biol Chem. 2009;284:23989-94 pubmed publisher
    Fission yeast Atf1 is a member of the ATF/CREB basic leucine zipper (bZIP) family of transcription factors with strong homology to mammalian ATF2...
  2. Soto T, Beltrán F, Paredes V, Madrid M, Millar J, Vicente Soler J, et al. Cold induces stress-activated protein kinase-mediated response in the fission yeast Schizosaccharomyces pombe. Eur J Biochem. 2002;269:5056-65 pubmed
    ..However, such activation is dispensable for yeast growth in cold conditions, supporting that the presence of Atf1/Pcr1 heterodimers, rather than an operative SAPK pathway, is critical to ensure yeast growth at low temperature by ..
  3. Zuin A, Castellano Esteve D, Ayte J, Hidalgo E. Living on the edge: stress and activation of stress responses promote lifespan extension. Aging (Albany NY). 2010;2:231-7 pubmed
    ..on the presence of a functional Sty1 stress pathway, since double mutants also lacking Sty1 or its main substrate Atf1 do not display extended viability...
  4. Takada H, Nishimura M, Asayama Y, Mannse Y, Ishiwata S, Kita A, et al. Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast. Mol Biol Cell. 2007;18:4794-802 pubmed
    ..ptc1(+) and ptc3(+), both encoding type 2C protein phosphatase (PP2C), previously known to inactivate the Wis1-Spc1-Atf1 stress-activated MAPK signaling pathway, suppressed the Cl(-) hypersensitivity of calcineurin deletion...
  5. Eshaghi M, Lee J, Zhu L, Poon S, Li J, Cho K, et al. Genomic binding profiling of the fission yeast stress-activated MAPK Sty1 and the bZIP transcriptional activator Atf1 in response to H2O2. PLoS ONE. 2010;5:e11620 pubmed publisher
    The evolutionally conserved MAPK Sty1 and bZIP transcriptional activator Atf1 are known to play a pivotal role in response to the reactive oxygen species in S. pombe...
  6. Kanoh J, Watanabe Y, Ohsugi M, Iino Y, Yamamoto M. Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation. Genes Cells. 1996;1:391-408 pubmed
    ..We took a genetic approach to this problem. The fission yeast gad7-1 mutant failed to arrest at G1 when starved of nitrogen, and was poor in mating and sporulation...
  7. Rodríguez Gabriel M, Russell P. Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryot Cell. 2005;4:1396-402 pubmed
    ..We conclude that the toxic effects of arsenic are not strongly connected to oxidative stress and that although Spc1 is activated by arsenic exposure, the basal activity of Spc1 is largely sufficient for the survival of arsenic. ..
  8. Nakagawa C, Yamada K, Mutoh N. Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe. J Biochem. 2000;127:233-8 pubmed
    ..fission yeast Schizosaccharomyces pombe in response to several stresses by using mutants of transcription factors (Atf1 and Pap1) and a series of deletion mutants of the ctt1(+) promoter region...
  9. Kon N, Krawchuk M, Warren B, Smith G, Wahls W. Transcription factor Mts1/Mts2 (Atf1/Pcr1, Gad7/Pcr1) activates the M26 meiotic recombination hotspot in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 1997;94:13765-70 pubmed
    ..Intriguingly, the Mts1/Mts2 protein subunits are identical to the recently described transcription factors Atf1 (Gad7) and Pcr1, which are required for a variety of stress responses...

More Information


  1. Toone W, Kuge S, Samuels M, Morgan B, Toda T, Jones N. Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1. Genes Dev. 1998;12:1453-63 pubmed
    ..Some of these phenotypes are caused by Sty1-dependent regulation of the Atf1 transcription factor, which controls both meiosis-specific and osmotic stress-responsive genes...
  2. Lawrence C, Jones N, Wilkinson C. Stress-induced phosphorylation of S. pombe Atf1 abrogates its interaction with F box protein Fbh1. Curr Biol. 2009;19:1907-11 pubmed publisher
    The Atf1 transcription factor is critical for directing stress-induced gene expression in fission yeast [1]...
  3. Wahls W, Smith G. A heteromeric protein that binds to a meiotic homologous recombination hot spot: correlation of binding and hot spot activity. Genes Dev. 1994;8:1693-702 pubmed
    ..We have purified 40,000-fold a heteromeric protein, containing polypeptides Mts1 (70 kD) and Mts2 (28 kD), that binds to the M26 site...
  4. Shiozaki K, Russell P. Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast. Genes Dev. 1996;10:2276-88 pubmed
    ..Two genes, atf1+ and atf21+, were cloned as multicopy suppressors of the spc1- mating defect...
  5. Paredes V, Franco A, Madrid M, Soto T, Vicente Soler J, Gacto M, et al. Transcriptional and post-translational regulation of neutral trehalase in Schizosaccharomyces pombe during thermal stress. Yeast. 2004;21:593-603 pubmed be involved in such control, since ntp1(+) expression under heat shock proved to be significantly blocked in atf1(+)-disrupted cells...
  6. Ohmiya R, Kato C, Yamada H, Aiba H, Mizuno T. Isolation of multicopy suppressors of the calcium sensitivity of a mutant lacking the bZIP transcription factor Atf1 in fission yeast. Mol Gen Genet. 1999;261:297-306 pubmed
    ..g., Atf1, Pcr1, Pap1), which function downstream of the Sty1 mitogen-activated protein kinase (MAPK) cascade which is ..
  7. Takeda T, Toda T, Kominami K, Kohnosu A, Yanagida M, Jones N. Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase. EMBO J. 1995;14:6193-208 pubmed
    We describe the identification and characterization of a transcription factor encoded by the atf1+ gene of the fission yeast Schizosaccharomyces pombe...
  8. Wilkinson M, Samuels M, Takeda T, Toone W, Shieh J, Toda T, et al. The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast. Genes Dev. 1996;10:2289-301 pubmed
    The atf1+ gene of Schizosaccharomyces pombe encodes a bZIP transcription factor with strong homology to the mammalian factor ATF-2...
  9. Jia S, Noma K, Grewal S. RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. Science. 2004;304:1971-6 pubmed
    ..However, in RNAi mutants, heterochromatin assembly can still occur at low efficiency. Here, we report that Atf1 and Pcr1, two ATF/CREB family proteins, act in a parallel mechanism to the RNAi pathway for heterochromatin ..
  10. Steiner W, Smith G. Optimizing the nucleotide sequence of a meiotic recombination hotspot in Schizosaccharomyces pombe. Genetics. 2005;169:1973-83 pubmed
    ..Previous analyses indicated that the heptamer 5'-ATGACGT-3' was necessary and sufficient for hotspot activity; the Atf1-Pcr1 transcription factor binds to this sequence and activates M26...
  11. Davidson M, Shandilya H, Hirota K, Ohta K, Wahls W. Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+. J Biol Chem. 2004;279:50857-63 pubmed
    ..Pathway integration is achieved via Spc1-dependent binding of Atf1-Pcr1 heterodimer to an M26 DNA site in the cgs2+ promoter, which remodels chromatin to regulate expression of cgs2+ ..
  12. Gao J, Davidson M, Wahls W. Phosphorylation-independent regulation of Atf1-promoted meiotic recombination by stress-activated, p38 kinase Spc1 of fission yeast. PLoS ONE. 2009;4:e5533 pubmed publisher
    ..The conserved, multifunctional, ATF/CREB protein Atf1 (Mts1, Gad7) of fission yeast binds to CRE-like (M26) DNA sites...
  13. Sansó M, Gogol M, Ayte J, Seidel C, Hidalgo E. Transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation. Eukaryot Cell. 2008;7:826-35 pubmed publisher
    ..Upon stress activation, Sty1 reversibly accumulates in the nucleus, where it stimulates gene expression via the Atf1 transcription factor...
  14. Reiter W, Watt S, Dawson K, Lawrence C, Bahler J, Jones N, et al. Fission yeast MAP kinase Sty1 is recruited to stress-induced genes. J Biol Chem. 2008;283:9945-56 pubmed publisher
    ..expression of many fission yeast genes is dependent upon the Sty1 mitogen-activated protein kinase (MAPK) and Atf1 transcription factor...
  15. Quinn J, Findlay V, Dawson K, Millar J, Jones N, Morgan B, et al. Distinct regulatory proteins control the graded transcriptional response to increasing H(2)O(2) levels in fission yeast Schizosaccharomyces pombe. Mol Biol Cell. 2002;13:805-16 pubmed
    ..the role of the Sty1 (Spc1) stress-activated mitogen-activated protein kinase pathway, and the Pap1 and Atf1 transcription factors, in regulating the response to H(2)O(2) in the fission yeast Schizosaccharomyces pombe...
  16. Gao J, Davidson M, Wahls W. Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response. Nucleic Acids Res. 2008;36:2838-51 pubmed publisher
    The Atf1 protein of Schizosaccharomyces pombe contains a bZIP (DNA-binding/protein dimerization) domain characteristic of ATF/CREB proteins, but no other functional domains or clear homologs have been reported...
  17. Gaits F, Degols G, Shiozaki K, Russell P. Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast. Genes Dev. 1998;12:1464-73 pubmed
    ..Thus, Spc1 must be phosphorylated by Wis1 to localize in the nucleus. Nuclear retention of Spc1 requires Atf1, a transcription factor that is the key nuclear substrate of Spc1...
  18. Greenall A, Hadcroft A, Malakasi P, Jones N, Morgan B, Hoffman C, et al. Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress. Mol Biol Cell. 2002;13:2977-89 pubmed
    In Schizosaccharomyces pombe, the Sty1 mitogen-activated protein kinase and the Atf1 transcription factor control transcriptional induction in response to elevated salt concentrations...
  19. Chen D, Wilkinson C, Watt S, Penkett C, Toone W, Jones N, et al. Multiple pathways differentially regulate global oxidative stress responses in fission yeast. Mol Biol Cell. 2008;19:308-17 pubmed
    ..These data reveal a considerable plasticity and differential control of regulatory pathways in distinct oxidative stress conditions, providing both specificity and backup for protection from oxidative damage. ..
  20. Buck V, Quinn J, Soto Pino T, Martin H, Saldanha J, Makino K, et al. Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway. Mol Biol Cell. 2001;12:407-19 pubmed
    ..We conclude that the transcriptional response to free radical attack is initiated by at least two distinct phospho-relay pathways in fission yeast. ..
  21. Madrid M, Soto T, Franco A, Paredes V, Vicente J, Hidalgo E, et al. A cooperative role for Atf1 and Pap1 in the detoxification of the oxidative stress induced by glucose deprivation in Schizosaccharomyces pombe. J Biol Chem. 2004;279:41594-602 pubmed
    ..the stress-activated protein kinase (SAPK) signal transduction pathway and promote increased transcription of Atf1-dependent genes coding for the general stress response...
  22. Kim H, Choi E, Shin J, Jang Y, Park S. Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6. J Biol Chem. 2004;279:42850-9 pubmed
    ..Here we find that activating transcription factor (Atf1) and Pcr1, the fission yeast bZIP transcription factors homologous to human ATF-2, are crucial for proper histone ..
  23. Degols G, Russell P. Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe. Mol Cell Biol. 1997;17:3356-63 pubmed
    ..cells, UV irradiation induces activation of Spc1 stress-activated protein kinase, which in turn phosphorylates the Atf1 bZIP transcription factor...
  24. Nguyen A, Lee A, Place W, Shiozaki K. Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase. Mol Biol Cell. 2000;11:1169-81 pubmed
    ..These studies show that oxidative stress stimuli are transmitted by multiple pathways to induce specific gene expression. ..
  25. Wahls W. RNA associated with a heterodimeric protein that activates a meiotic homologous recombination hot spot: RL/RT/PCR strategy for cloning any unknown RNA or DNA. PCR Methods Appl. 1994;3:272-7 pubmed
    ..We have achieved 40,000-fold purification of a heterodimeric DNA-binding protein, Mts1/Mts2, that activates the recombination hot spot. Physical studies suggested the presence of a third subunit...
  26. Paulo E, García Santamarina S, Calvo I, Carmona M, Boronat S, Domènech A, et al. A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase. Mol Microbiol. 2014;92:246-57 pubmed publisher
    ..pombe genome, only has a minor secondary role when extracellular peroxides are added. Our study proposes non-overlapping roles for the different hydrogen peroxide scavenging activities of this eukaryotic organism. ..
  27. Wang L, Shimada K, Morishita M, Shiozaki K. Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase. Mol Cell Biol. 2005;25:3945-55 pubmed
    ..Spc1 positively regulates expression of sod2(+) encoding a Na(+)/H(+) antiporter through Atf1 and other transcription factors...
  28. Martin V, Rodríguez Gabriel M, McDonald W, Watt S, Yates J, Bahler J, et al. Cip1 and Cip2 are novel RNA-recognition-motif proteins that counteract Csx1 function during oxidative stress. Mol Biol Cell. 2006;17:1176-83 pubmed
    ..It does so by stabilizing atf1(+) mRNA, which encodes a subunit of a bZIP transcription factor required for gene expression during oxidative ..
  29. Bandyopadhyay S, Dey I, Suresh M, Sundaram G. The basic leucine zipper domain transcription factor Atf1 directly controls Cdc13 expression and regulates mitotic entry independently of Wee1 and Cdc25 in Schizosaccharomyces pombe. Eukaryot Cell. 2014;13:813-21 pubmed publisher
    ..pombe. We show that the mitogen-activated protein kinase (MAPK)-regulated transcription factor Atf1 is a regulator of Cdc13 (mitotic cyclin) transcription and is therefore a prominent player in the regulation of ..
  30. Zhou X, Ma Y, Kato T, Kuno T. A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities. J Biol Chem. 2012;287:23434-9 pubmed publisher
    ..The Sty1 MAPK regulates Atf1 transcription factor to elicit stress responses in extreme conditions of osmolarity and reactive oxygen species-..
  31. Bandyopadhyay S, Ghosh P, Basu S, Paul M, Alam S, Das E, et al. Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition. FEMS Microbiol Lett. 2017;364: pubmed publisher
    The transcription factor Atf1 is known to promote cell survival during various stress conditions in Schizosaccharomyces pombe by activating the expression of appropriate genes...
  32. Yamada K, Nakagawa C, Mutoh N. Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant. Yeast. 1999;15:1125-32 pubmed
    ..These stresses activate the Wis1-Sty1/Spc1 MAP kinase cascade in S. pombe. Transcriptional factors Atf1 and Pap1 are under the control of this MAP kinase...
  33. Yamada S, Okamura M, Oda A, Murakami H, Ohta K, Yamada T. Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. Genetics. 2017;206:801-809 pubmed publisher
    ..similar to the cyclic AMP response element and activated by the ATF/CREB family transcription factor dimer Atf1-Pcr1. We first focused on one of those hotspots, ade6-3049, and Atf1...
  34. Jang Y, Won M, Yoo H. Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase. Yeast. 2013;30:379-94 pubmed publisher
  35. Shiozaki K, Russell P. Stress-activated protein kinase pathway in cell cycle control of fission yeast. Methods Enzymol. 1997;283:506-20 pubmed
  36. Yoshida J, Tani T. Hsp16p is required for thermotolerance in nuclear mRNA export in fission yeast Schizosaccharomyces pombe. Cell Struct Funct. 2005;29:125-38 pubmed
    ..We also found that Hsp16p, the expression of which is controlled by Atf1p, is involved in acquisition of thermotolerance in mRNA export in S. pombe. ..
  37. Stone M, Hartmann Petersen R, Seeger M, Bech Otschir D, Wallace M, Gordon C. Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast. J Mol Biol. 2004;344:697-706 pubmed
    ..the activity of Ubp6 appears to play a more regulatory and/or structural role involving the proteasome subunits Mts1/Rpn9, Mts2/Rpt2 and Mts3/Rpn12, as Ubp6 becomes essential when activity of these subunits is compromised by ..
  38. Wilkinson C, Ferrell K, Penney M, Wallace M, Dubiel W, Gordon C. Analysis of a gene encoding Rpn10 of the fission yeast proteasome reveals that the polyubiquitin-binding site of this subunit is essential when Rpn12/Mts3 activity is compromised. J Biol Chem. 2000;275:15182-92 pubmed
    ..The Mts3 protein was unable to bind to polyubiquitin in vitro, but the Pus1 and Mts3 proteins were found to bind to one another in vitro, which taken together with the genetic data suggests that they are also closely associated in vivo. ..
  39. Song S, Kim B, Lim C, Song Y, Park E. Expression of the atf1+ gene is upregulated in fission yeast under nitrosative and nutritional stresses. Can J Microbiol. 2009;55:1323-7 pubmed publisher
    This work was designed to assess regulation of the atf1+ gene in the fission yeast Schizosaccharomyces pombe under nitrosative and nutritional stresses, using the atf1+-lacZ fusion gene and RT-PCR...
  40. Kawasaki Y, Nagao K, Nakamura T, Yanagida M. Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses. Cell Cycle. 2006;5:1831-9 pubmed
    ..Securin bound to separase was hyperphosphorylated. The stresses could not rescue the indestructible Cut2 and Rad21 mutants. We postulate that the stresses produce the hyperchaperonic form of Cut2 that can rescue separase mutations. ..
  41. Kim S, Shin Y, Kim K, Park E, Sa J, Lim C. Regulation of the gene encoding glutathione synthetase from the fission yeast. J Biochem Mol Biol. 2003;36:326-31 pubmed
    ..It was also induced by L-buthionine-(S,R)-sulfoximine, a specific inhibitor of gamma-glutamylcysteine synthetase (GCS). We also found that the expression of the S. pombe GS gene is regulated by the Atf1-Spc1-Wis1 signal pathway.
  42. Udagawa T, Nemoto N, Wilkinson C, Narashimhan J, Jiang L, Watt S, et al. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. J Biol Chem. 2008;283:22063-75 pubmed publisher
    ..In agreement with this, Sty1 MAPK and its target transcription factor Atf1, which signal the CESR, are required for overcoming 3AT-induced starvation...
  43. Asada R, Takemata N, Hoffman C, Ohta K, Hirota K. Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor. Mol Cell Biol. 2015;35:847-55 pubmed publisher
    ..First, Tup11/12 inhibit chromatin remodeling in the fbp1⁺ promoter region where the Atf1 and Rst2 transcriptional activators bind...
  44. Shieh J, Wilkinson M, Buck V, Morgan B, Makino K, Millar J. The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle. Genes Dev. 1997;11:1008-22 pubmed
  45. Sundaram G, Palchaudhuri S, Chaudhuri S, Karunanithi S, Chattopadhyay D. Characterization of Sro1, a novel stress responsive protein in Schizosaccharomyces pombe. FEMS Yeast Res. 2008;8:564-73 pubmed publisher regulated mainly through the stress activated protein kinase (SAPK) Sty1 and its downstream transcription factor Atf1. Deletion of Sro1 also significantly alters the reactive oxygen species (ROS) generation profiles and the cell-..
  46. Gao J, Wagnon J, Protacio R, Glazko G, Beggs M, Raj V, et al. A stress-activated, p38 mitogen-activated protein kinase-ATF/CREB pathway regulates posttranscriptional, sequence-dependent decay of target RNAs. Mol Cell Biol. 2013;33:3026-35 pubmed publisher
    ..The Spc1 (Sty1/Phh1) kinase-regulated Atf1-Pcr1 (Mts1-Mts2) heterodimer of the fission yeast Schizosaccharomyces pombe controls the stress-induced, ..
  47. García P, Paulo E, Gao J, Wahls W, Ayté J, Lowy E, et al. Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription. Nucleic Acids Res. 2014;42:10351-9 pubmed publisher
    ..large transcriptional response common to several stress conditions, regulated primarily by the transcription factor Atf1. Atf1-dependent promoters contain especially broad nucleosome depleted regions (NDRs) prior to stress imposition...
  48. Janoo R, Neely L, Braun B, Whitehall S, Hoffman C. Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex. Genetics. 2001;157:1205-15 pubmed
    ..In strains lacking tup11 and tup12, the atf1-pcr1 transcriptional activator continues to play a central role in fbp1-lacZ expression; however, spc1 MAPK ..
  49. Woolcock K, Stunnenberg R, Gaidatzis D, Hotz H, Emmerth S, Barraud P, et al. RNAi keeps Atf1-bound stress response genes in check at nuclear pores. Genes Dev. 2012;26:683-92 pubmed publisher
    ..Taken together, our work highlights a role for nuclear pores and the stress response transcription factor Atf1 in coordinating the interplay between the RNAi machinery and the S...
  50. Kato H, Kira S, Kawamukai M. The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast. PLoS ONE. 2013;8:e80572 pubmed publisher
    ..This was dependent on Atf1 and Pcr1, which are highly conserved transcription factors that regulate stress-responsive genes in various stress ..
  51. Nemoto N, Udagawa T, Ohira T, Jiang L, Hirota K, Wilkinson C, et al. The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation. J Mol Biol. 2010;404:183-201 pubmed publisher
    ..The translation factor subunit Int6/eIF3e promotes Sty1-dependent response by increasing the abundance of Atf1, a transcription factor targeted by Sty1...
  52. Wilkinson C, Seeger M, Hartmann Petersen R, Stone M, Wallace M, Semple C, et al. Proteins containing the UBA domain are able to bind to multi-ubiquitin chains. Nat Cell Biol. 2001;3:939-43 pubmed
    ..These two proteins are implicated, along with the fission-yeast Pus1(S5a/Rpn10) subunit of the 26 S proteasome, in the recognition and turnover of substrates by this proteolytic complex. ..
  53. López Avilés S, Lambea E, Moldón A, Grande M, Fajardo A, Rodríguez Gabriel M, et al. Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation. Mol Biol Cell. 2008;19:1670-9 pubmed publisher
  54. Takada H, Nishida A, Domae M, Kita A, Yamano Y, Uchida A, et al. The cell surface protein gene ecm33+ is a target of the two transcription factors Atf1 and Mbx1 and negatively regulates Pmk1 MAPK cell integrity signaling in fission yeast. Mol Biol Cell. 2010;21:674-85 pubmed publisher
    The highly conserved fission yeast Pmk1 MAPK pathway plays a key role in cell integrity by regulating Atf1, which belongs to the ATF/cAMP-responsive element-binding (CREB) protein family...
  55. Nguyen A, Shiozaki K. Heat-shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases. Genes Dev. 1999;13:1653-63 pubmed
    ..Thus, transient activation of Spc1 upon heat shock is ensured by differential regulation of threonine and tyrosine phosphorylation. ..
  56. Salat Canela C, Paulo E, Sánchez Mir L, Carmona M, Ayte J, Oliva B, et al. Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation. J Biol Chem. 2017;292:13635-13644 pubmed publisher
    ..Sty1 accumulates in the nucleus and stimulates expression of hundreds of genes via the nuclear transcription factor Atf1, including expression of atf1 itself...
  57. Day A, Veal E. Hydrogen peroxide-sensitive cysteines in the Sty1 MAPK regulate the transcriptional response to oxidative stress. J Biol Chem. 2010;285:7505-16 pubmed publisher
    ..Many Sty1-dependent changes in gene expression are mediated by the Atf1 transcription factor...