Gene Symbol: ase1
Description: antiparallel microtubule cross-linking factor Ase1
Alias: antiparallel microtubule cross-linking factor Ase1
Species: fission yeast

Top Publications

  1. Yamashita A, Sato M, Fujita A, Yamamoto M, Toda T. The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling. Mol Biol Cell. 2005;16:1378-95 pubmed
    The Ase1/Prc1 proteins constitute a conserved microtubule-associated protein family that is implicated in central spindle formation and cytokinesis. Here we characterize a role for fission yeast Ase1...
  2. Loiodice I, Staub J, Setty T, Nguyen N, Paoletti A, Tran P. Ase1p organizes antiparallel microtubule arrays during interphase and mitosis in fission yeast. Mol Biol Cell. 2005;16:1756-68 pubmed
    ..We identify fission yeast ase1p, a member of the conserved ASE1/PRC1/MAP65 family of microtubule bundling proteins, which functions in organizing the spindle midzone during ..
  3. Bratman S, Chang F. Stabilization of overlapping microtubules by fission yeast CLASP. Dev Cell. 2007;13:812-27 pubmed
    ..These findings show how a MT-stabilizing factor attached to specific sites on MTs can help to generate MT structures that have both dynamic and stable components. ..
  4. Fu C, Ward J, Loiodice I, Velve Casquillas G, Nedelec F, Tran P. Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation. Dev Cell. 2009;17:257-67 pubmed publisher
  5. Roque H, Ward J, Murrells L, Brunner D, Antony C. The fission yeast XMAP215 homolog Dis1p is involved in microtubule bundle organization. PLoS ONE. 2010;5:e14201 pubmed publisher
    ..In addition, we show that ase1p is the major determinant of inter-microtubule spacing in interphase bundles since ase1 deleted cells have an inter-microtubule spacing that differs from that observed in wild-type cells...
  6. Meadows J, Millar J. Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stability. Mol Biol Cell. 2008;19:3713-23 pubmed publisher
    ..This effect is abolished in a latrunculin A-insensitive actin mutant and exacerbated in cells lacking Ase1, which cross-links antiparallel interpolar microtubules at the spindle midzone both before and after anaphase...
  7. Kapitein L, Janson M, van den Wildenberg S, Hoogenraad C, Schmidt C, Peterman E. Microtubule-driven multimerization recruits ase1p onto overlapping microtubules. Curr Biol. 2008;18:1713-7 pubmed publisher
    ..In controlled in vitro experiments, dimers of ase1-GFP diffused along the surface of single MTs and, at concentrations above a certain threshold, assembled into ..
  8. Hölig K, Kramer M, Kroschinsky F, Bornhauser M, Mengling T, Schmidt A, et al. Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in unrelated volunteers: 12 years of single-center experience in 3928 donors. Blood. 2009;114:3757-63 pubmed publisher
    ..Long-term monitoring of healthy PBSC donors remains important to guarantee the safety standards of PBSC mobilization and collection. ..
  9. Wälde S, King M. The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body. J Cell Sci. 2014;127:3625-40 pubmed publisher
    ..Plo1 activity supports mitotic SPB remodeling by driving a burst of incorporation of Cut12 and Pcp1. Thus, a fission yeast SUN-KASH complex plays an important role in supporting the remodeling of the SPB at mitotic entry. ..

More Information


  1. Lucena R, Dephoure N, Gygi S, Kellogg D, Tallada V, Daga R, et al. Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly. J Cell Biol. 2015;209:387-402 pubmed publisher
    ..Our findings illustrate how a separate membrane compartment supports spindle disassembly in the closed mitosis of fission yeast. ..
  2. Braun M, Lansky Z, Fink G, Ruhnow F, Diez S, Janson M. Adaptive braking by Ase1 prevents overlapping microtubules from sliding completely apart. Nat Cell Biol. 2011;13:1259-64 pubmed publisher
    ..Here, we show that Ase1, a member of the conserved MAP65/PRC1 family of microtubule-bundling proteins, enables the formation of stable ..
  3. Lansky Z, Braun M, Lüdecke A, Schlierf M, ten Wolde P, Janson M, et al. Diffusible crosslinkers generate directed forces in microtubule networks. Cell. 2015;160:1159-68 pubmed publisher
    ..Here, we experimentally demonstrate that diffusible microtubule crosslinkers of the Ase1/PRC1/Map65 family generate directed microtubule sliding when confined between partially overlapping microtubules...
  4. Laporte D, Courtout F, Pinson B, Dompierre J, Salin B, Brocard L, et al. A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit. J Cell Biol. 2015;210:99-113 pubmed publisher
    ..Our work demonstrates that quiescent S. pombe cells assemble specific cytoskeleton structures that improve the swiftness of the transition back to proliferation. ..
  5. Namkung Y, Sibley D. Protein kinase C mediates phosphorylation, desensitization, and trafficking of the D2 dopamine receptor. J Biol Chem. 2004;279:49533-41 pubmed
    ..These results indicate that PKC can mediate phosphorylation of the D2 DAR, resulting in both functional desensitization and receptor internalization. ..
  6. Courtheoux T, Gay G, Gachet Y, Tournier S. Ase1/Prc1-dependent spindle elongation corrects merotely during anaphase in fission yeast. J Cell Biol. 2009;187:399-412 pubmed publisher
    ..provide in vivo evidence that correction of merotelic attachment in anaphase is tension dependent and requires an Ase1/Prc1-dependent mechanism that prevents spindle collapse and thus asymmetric division and/or the appearance of the ..
  7. Gupta S, Mana Capelli S, McLean J, Chen C, Ray S, Gould K, et al. Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways. Curr Biol. 2013;23:333-8 pubmed publisher
    ..Because the SIN and MOR are conserved in mammalian cells (Hippo and Ndr1/2 pathways, respectively), this work may provide important insight into how the activities of these essential pathways are coordinated...