Gene Symbol: ain1
Description: alpha-actinin
Alias: alpha-actinin
Species: fission yeast

Top Publications

  1. Wu J, Bahler J, Pringle J. Roles of a fimbrin and an alpha-actinin-like protein in fission yeast cell polarization and cytokinesis. Mol Biol Cell. 2001;12:1061-77 pubmed
    ..b>ain1 deletion cells have no obvious defects under normal growth conditions but display severe cytokinesis defects, ..
  2. Wu J, Kuhn J, Kovar D, Pollard T. Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis. Dev Cell. 2003;5:723-34 pubmed
    ..Ring contraction and disassembly begin 37 min after SPB separation. This spatial and temporal hierarchy provides the framework for analysis of molecular mechanisms. ..
  3. Nakano K, Mabuchi I. Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast. Genes Cells. 2006;11:893-905 pubmed
    ..In addition, CP is likely involved in assembling the F-actin contractile ring and F-actin patch with F-actin-crosslinking proteins. ..
  4. Chen Q, Pollard T. Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ring. J Cell Biol. 2011;195:485-98 pubmed publisher
  5. Laporte D, Ojkic N, Vavylonis D, Wu J. ?-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly. Mol Biol Cell. 2012;23:3094-110 pubmed publisher
    ..By mutating or titrating actin cross-linkers ?-actinin Ain1 and fimbrin Fim1 in live cells, we reveal that both proteins are involved in node condensation...
  6. Kovar D, Wu J, Pollard T. Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast. Mol Biol Cell. 2005;16:2313-24 pubmed
    ..Given that capping protein arrives at the division site 20 min later than Cdc12p, capping protein may slowly replace Cdc12p on filament barbed ends in preparation for filament disassembly during ring constriction. ..
  7. Wang N, Lo Presti L, Zhu Y, Kang M, Wu Z, Martin S, et al. The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis. J Cell Biol. 2014;205:357-75 pubmed publisher
    ..Purified Rng8 and Rng9 form stable higher-order complexes. Collectively, we propose that Rng8 and Rng9 form oligomers and cluster multiple Myo51 dimers to regulate Myo51 localization and functions. ..
  8. Li Y, Christensen J, Homa K, Hocky G, Fok A, Sees J, et al. The F-actin bundler ?-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast. Mol Biol Cell. 2016;27:1821-33 pubmed publisher
    ..Together our results demonstrate that dynamic bundling by SpAin1 is important for proper contractile ring formation and constriction. ..