Gene Symbol: acp2
Description: putative F-actin-capping protein beta subunit acp2
Species: fission yeast

Top Publications

  1. Skau C, Courson D, Bestul A, Winkelman J, Rock R, Sirotkin V, et al. Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast. J Biol Chem. 2011;286:26964-77 pubmed publisher
    ..Therefore, fimbrin Fim1 has diverse roles as both a filament "gatekeeper" and as a filament cross-linker. ..
  2. Kovar D, Wu J, Pollard T. Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast. Mol Biol Cell. 2005;16:2313-24 pubmed
    ..Neither acp1 nor acp2 is required for viability, but cells lacking either or both subunits have cytokinesis defects under stressful ..
  3. Sirotkin V, Berro J, Macmillan K, Zhao L, Pollard T. Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast. Mol Biol Cell. 2010;21:2894-904 pubmed publisher
  4. Wu J, Kuhn J, Kovar D, Pollard T. Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis. Dev Cell. 2003;5:723-34 pubmed
    ..Ring contraction and disassembly begin 37 min after SPB separation. This spatial and temporal hierarchy provides the framework for analysis of molecular mechanisms. ..
  5. Nakano K, Mabuchi I. Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast. Mol Biol Cell. 2006;17:1933-45 pubmed
    ..Tropomyosin was shown to antagonize the function of Adf1 in the contractile ring. We propose that formation and maintenance of the contractile ring are achieved by a balanced collaboration of these proteins. ..
  6. Laporte D, Courtout F, Pinson B, Dompierre J, Salin B, Brocard L, et al. A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit. J Cell Biol. 2015;210:99-113 pubmed publisher
    ..Our work demonstrates that quiescent S. pombe cells assemble specific cytoskeleton structures that improve the swiftness of the transition back to proliferation. ..
  7. Baker K, Kirkham S, Hálová L, Atkin J, Franz Wachtel M, Cobley D, et al. TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis. J Cell Sci. 2016;129:2613-24 pubmed publisher
    ..of actin-capping protein 1 (Acp1, a known regulator of cytokinesis) controls CAR stability, modulates Acp1-Acp2 (the equivalent of the mammalian CAPZA-CAPZB) heterodimer formation and is essential for survival upon stress...
  8. Nakano K, Satoh K, Morimatsu A, Ohnuma M, Mabuchi I. Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton. Mol Biol Cell. 2001;12:3515-26 pubmed
    ..Finally, genetic studies suggested that Fim1 may function in cytokinesis in cooperation with Cdc15 (PSTPIP) and Rng2 (IQGAP), respectively. ..
  9. Nakano K, Bunai F, Numata O. Stg 1 is a novel SM22/transgelin-like actin-modulating protein in fission yeast. FEBS Lett. 2005;579:6311-6 pubmed

More Information


  1. Nakano K, Mabuchi I. Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast. Genes Cells. 2006;11:893-905 pubmed
    ..Here we investigated the function of CP in fission yeast cells. The fission yeast CP is composed of Acp1 and Acp2. It was found that Acp2 accumulated as cortical dots at the cell ends during interphase and the mid-region of ..
  2. Berro J, Pollard T. Synergies between Aip1p and capping protein subunits (Acp1p and Acp2p) in clathrin-mediated endocytosis and cell polarization in fission yeast. Mol Biol Cell. 2014;25:3515-27 pubmed publisher
    ..We identified two independent pathways that control polarization of endocytic sites, one depending on acp2(+) and aip1(+) during interphase and the other independent of acp1(+), acp2(+), and aip1(+) during mitosis.