Gene Symbol: acp1
Description: F-actin-capping protein alpha subunit
Alias: F-actin-capping protein alpha subunit
Species: fission yeast
Kovar D, Wu J, Pollard T. Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast. Mol Biol Cell. 2005;16:2313-24 pubmed
..Neither acp1 nor acp2 is required for viability, but cells lacking either or both subunits have cytokinesis defects under ..
Skau C, Courson D, Bestul A, Winkelman J, Rock R, Sirotkin V, et al
. Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast. J Biol Chem. 2011;286:26964-77 pubmed publisher
..Therefore, fimbrin Fim1 has diverse roles as both a filament "gatekeeper" and as a filament cross-linker. ..
Katayama S, Hirata D, Arellano M, Perez P, Toda T. Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function. J Cell Biol. 1999;144:1173-86 pubmed
..These results indicate that Mok1 plays a crucial role in cell morphogenesis interdependently of the actin cytoskeleton and works as one of downstream effectors for Pck1/2. ..
Berro J, Pollard T. Synergies between Aip1p and capping protein subunits (Acp1p and Acp2p) in clathrin-mediated endocytosis and cell polarization in fission yeast. Mol Biol Cell. 2014;25:3515-27 pubmed publisher
..We identified two independent pathways that control polarization of endocytic sites, one depending on acp2(+) and aip1(+) during interphase and the other independent of acp1(+), acp2(+), and aip1(+) during mitosis.
Nakano K, Satoh K, Morimatsu A, Ohnuma M, Mabuchi I. Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton. Mol Biol Cell. 2001;12:3515-26 pubmed
..Thus, Fim1 may function in stabilizing the F-actin patches. We also isolated the gene encoding Acp1, a subunit of the heterodimeric F-actin capping protein...
Nakano K, Bunai F, Numata O. Stg 1 is a novel SM22/transgelin-like actin-modulating protein in fission yeast. FEBS Lett. 2005;579:6311-6 pubmed
Nakano K, Mabuchi I. Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast. Mol Biol Cell. 2006;17:1933-45 pubmed
..Tropomyosin was shown to antagonize the function of Adf1 in the contractile ring. We propose that formation and maintenance of the contractile ring are achieved by a balanced collaboration of these proteins. ..
Baker K, Kirkham S, Hálová L, Atkin J, Franz Wachtel M, Cobley D, et al
. TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis. J Cell Sci. 2016;129:2613-24 pubmed publisher
..We go on to show that TORC2-dependent phosphorylation of actin-capping protein 1 (Acp1, a known regulator of cytokinesis) controls CAR stability, modulates Acp1-Acp2 (the equivalent of the mammalian ..
Nakano K, Mabuchi I. Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast. Genes Cells. 2006;11:893-905 pubmed
..Here we investigated the function of CP in fission yeast cells. The fission yeast CP is composed of Acp1 and Acp2...