Gene Symbol: S
Description: receptor binding molecule
Alias: receptor binding molecule, spike protein
Chang H, Egberink H, Halpin R, Spiro D, Rottier P. Spike protein fusion peptide and feline coronavirus virulence. Emerg Infect Dis. 2012;18:1089-95 pubmed publisher
..As a result, we identified 2 alternative amino acid differences in the putative fusion peptide of the spike protein that together distinguish FIPV from FECV in >95% of cases...
Terada Y, Shiozaki Y, Shimoda H, Mahmoud H, Noguchi K, Nagao Y, et al
. Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats. J Gen Virol. 2012;93:1930-4 pubmed publisher
..peritonitis virus (FIPV), C3663, was found to have a large deletion of 735 bp within the gene encoding the spike (S) protein, with a deduced loss of 245 aa of the N-terminal region of the S protein...
Porter E, Tasker S, Day M, Harley R, Kipar A, Siddell S, et al
. Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis. Vet Res. 2014;45:49 pubmed publisher
Recent evidence suggests that a mutation in the spike protein gene of feline coronavirus (FCoV), which results in an amino acid change from methionine to leucine at position 1058, may be associated with feline infectious peritonitis (FIP)..
Bank Wolf B, Stallkamp I, Wiese S, Moritz A, Tekes G, Thiel H. Mutations of 3c and spike protein genes correlate with the occurrence of feline infectious peritonitis. Vet Microbiol. 2014;173:177-88 pubmed publisher
..The M protein gene was found to be conserved between FECV and FIPV samples. Our findings suggest that mutations of 3c and spike protein genes correlate with the occurrence of FIP.
de Groot R, Maduro J, Lenstra J, Horzinek M, van der Zeijst B, Spaan W. cDNA cloning and sequence analysis of the gene encoding the peplomer protein of feline infectious peritonitis virus. J Gen Virol. 1987;68 ( Pt 10):2639-46 pubmed
..Comparison of the sequences of the FIPV, murine hepatitis virus and infectious bronchitis virus peplomer proteins showed about 27% overall homology, with most conservation in the C-terminal half. ..
Phillips J, Hilt D, Jackwood M. Comparative sequence analysis of full-length genome of FIPV at different tissue passage levels. Virus Genes. 2013;47:490-7 pubmed publisher
..Our data show that FIPV has a low mutation rate as it is passed in cell culture but has the capacity for change specifically in nsp 2, 3c, and 7b as it is passed in cell culture. ..