Gene Symbol: FAT1
- Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acidsN J Faergeman
Department of Biochemistry, University of Tennessee College of Medicine, Memphis, Tennessee 38163, USA
J Biol Chem 272:8531-8. 1997..cerevisiae have not been described. We report the characterization of FAT1, a gene that encodes a putative membrane-bound long-chain fatty acid transport protein (Fat1p)...
- Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrationsP A Watkins
Kennedy Krieger Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 273:18210-9. 1998..We identified a candidate yeast VLCS gene (FAT1), previously identified as encoding a fatty acid transport protein, by its homology to rat liver peroxisomal VLCS...
- The Saccharomyces cerevisiae FAT1 gene encodes an acyl-CoA synthetase that is required for maintenance of very long chain fatty acid levelsJ Y Choi
Division of Life Sciences, the Bureau of Biological Research, Nelson Laboratories, Rutgers University, Piscataway, New Jersey 08854 808
J Biol Chem 274:4671-83. 1999The Saccharomyces cerevisiae FAT1 gene appears to encode an acyl-CoA synthetase that is involved in the regulation of very long chain (C20-C26) fatty acids...
- Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiaeK Athenstaedt
Institut fur Biochemie und Lebensmittelchemie, Technische Universität and SFB Biomembrane Research Center, Petersgasse 12 2, A 8010 Graz, Austria
J Bacteriol 181:6441-8. 1999..Strains with YBR177c, YMR313c, and YKL140w deleted exhibited phospholipid and/or neutral lipid patterns that were different from the wild-type strain and thus may be further candidate ORFs involved in yeast lipid metabolism...
- Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complexZhiying Zou
Center for Cardiovascular Sciences, Albany Medical College MC 8, 47 New Scotland Avenue, Albany, NY 12208, USA
J Biol Chem 278:16414-22. 2003..Multicopy extragenic suppressors were selected in strains carrying deletions in FAA1 and FAA4 or FAA1 and FAT1. Each strain is unable to grow under synthetic lethal conditions when exogenous long-chain fatty acids are required,..
- Topology of the yeast fatty acid transport protein Fat1p: mechanistic implications for functional domains on the cytosolic surface of the plasma membraneThomas Obermeyer
Center for Metabolic Disease, Ordway Research Institute, Albany Medical College, Albany, NY 12208, USA
J Lipid Res 48:2354-64. 2007..This topological orientation is consistent with the mechanistic roles of both Fat1p and Faa1p or Faa4p in the coupled transport/activation of exogenous fatty acids by vectorial acylation...
- Murine FATP alleviates growth and biochemical deficiencies of yeast fat1Delta strainsC C DiRusso
Center for Cardiovascular Sciences, Albany Medical College, NY 12208 3479, USA
Eur J Biochem 267:4422-33. 2000..The FAT1 gene encodes a protein, Fat1p, which is required for maximal levels of fatty-acid import and has an acyl CoA ..
- Acyl-CoA synthetase ACSVL3 in Malignant Glioma: Metabolism and Oncogenic CellularPaul Watkins; Fiscal Year: 2009..Results of these studies will provide a critical assessment of the mechanism by which this enzyme contributes to the malignant phenotype, and the potential therapeutic benefit of targeting this enzyme in glioma. ..
- XALD: Role of Very Long Chain Fatty Acyl-CoA SynthetasesPaul Watkins; Fiscal Year: 2006..Furthermore, they will facilitate elucidation of the role of enzymes belonging to the VLACS or BG families in XALD. ..
- Brain Uptake and Utilization of Fatty Acids and LipidsPaul Watkins; Fiscal Year: 2004..Mol. Neurosci., which has committed to publish the proceedings of the proposed meeting. ..
- XALD--ROLE OF VERY LONG CHAIN FATTY ACYL COA SYNTHETASESPaul Watkins; Fiscal Year: 2002..abstract_text> ..
- Acyl-CoA synthetase ACSVL3 in Malignant Glioma: Metabolism and Oncogenic CellularPaul A Watkins; Fiscal Year: 2010..Results of these studies will provide a critical assessment of the mechanism by which this enzyme contributes to the malignant phenotype, and the potential therapeutic benefit of targeting this enzyme in glioma. ..