FAT1

Summary

Gene Symbol: FAT1
Description: Fat1p
Species:

Top Publications

  1. ncbi Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids
    N J Faergeman
    Department of Biochemistry, University of Tennessee College of Medicine, Memphis, Tennessee 38163, USA
    J Biol Chem 272:8531-8. 1997
  2. ncbi Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrations
    P A Watkins
    Kennedy Krieger Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:18210-9. 1998
  3. ncbi The Saccharomyces cerevisiae FAT1 gene encodes an acyl-CoA synthetase that is required for maintenance of very long chain fatty acid levels
    J Y Choi
    Division of Life Sciences, the Bureau of Biological Research, Nelson Laboratories, Rutgers University, Piscataway, New Jersey 08854 808
    J Biol Chem 274:4671-83. 1999
  4. ncbi Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae
    K Athenstaedt
    Institut fur Biochemie und Lebensmittelchemie, Technische Universität and SFB Biomembrane Research Center, Petersgasse 12 2, A 8010 Graz, Austria
    J Bacteriol 181:6441-8. 1999
  5. ncbi Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex
    Zhiying Zou
    Center for Cardiovascular Sciences, Albany Medical College MC 8, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Biol Chem 278:16414-22. 2003
  6. ncbi Topology of the yeast fatty acid transport protein Fat1p: mechanistic implications for functional domains on the cytosolic surface of the plasma membrane
    Thomas Obermeyer
    Center for Metabolic Disease, Ordway Research Institute, Albany Medical College, Albany, NY 12208, USA
    J Lipid Res 48:2354-64. 2007
  7. ncbi Murine FATP alleviates growth and biochemical deficiencies of yeast fat1Delta strains
    C C DiRusso
    Center for Cardiovascular Sciences, Albany Medical College, NY 12208 3479, USA
    Eur J Biochem 267:4422-33. 2000

Research Grants

  1. Acyl-CoA synthetase ACSVL3 in Malignant Glioma: Metabolism and Oncogenic Cellular
    Paul Watkins; Fiscal Year: 2009
  2. XALD: Role of Very Long Chain Fatty Acyl-CoA Synthetases
    Paul Watkins; Fiscal Year: 2006
  3. Brain Uptake and Utilization of Fatty Acids and Lipids
    Paul Watkins; Fiscal Year: 2004
  4. XALD--ROLE OF VERY LONG CHAIN FATTY ACYL COA SYNTHETASES
    Paul Watkins; Fiscal Year: 2002
  5. Acyl-CoA synthetase ACSVL3 in Malignant Glioma: Metabolism and Oncogenic Cellular
    Paul A Watkins; Fiscal Year: 2010

Scientific Experts

  • P A Watkins
  • Thomas Obermeyer
  • Concetta C DiRusso
  • Paul N Black
  • C C DiRusso
  • Zhiying Zou
  • N J Faergeman
  • K Athenstaedt
  • J Y Choi
  • Peter Fraisl
  • J Knudsen
  • P N Black
  • Fumin Tong
  • Claus Børsting
  • Nils J Faergeman
  • J K Hansen
  • E J Connell
  • D Zweytick
  • G Daum
  • S D Kohlwein
  • C E Martin
  • A Jandrositz
  • A Elberger

Detail Information

Publications7

  1. ncbi Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids
    N J Faergeman
    Department of Biochemistry, University of Tennessee College of Medicine, Memphis, Tennessee 38163, USA
    J Biol Chem 272:8531-8. 1997
    ..cerevisiae have not been described. We report the characterization of FAT1, a gene that encodes a putative membrane-bound long-chain fatty acid transport protein (Fat1p)...
  2. ncbi Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrations
    P A Watkins
    Kennedy Krieger Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:18210-9. 1998
    ..We identified a candidate yeast VLCS gene (FAT1), previously identified as encoding a fatty acid transport protein, by its homology to rat liver peroxisomal VLCS...
  3. ncbi The Saccharomyces cerevisiae FAT1 gene encodes an acyl-CoA synthetase that is required for maintenance of very long chain fatty acid levels
    J Y Choi
    Division of Life Sciences, the Bureau of Biological Research, Nelson Laboratories, Rutgers University, Piscataway, New Jersey 08854 808
    J Biol Chem 274:4671-83. 1999
    The Saccharomyces cerevisiae FAT1 gene appears to encode an acyl-CoA synthetase that is involved in the regulation of very long chain (C20-C26) fatty acids...
  4. ncbi Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae
    K Athenstaedt
    Institut fur Biochemie und Lebensmittelchemie, Technische Universität and SFB Biomembrane Research Center, Petersgasse 12 2, A 8010 Graz, Austria
    J Bacteriol 181:6441-8. 1999
    ..Strains with YBR177c, YMR313c, and YKL140w deleted exhibited phospholipid and/or neutral lipid patterns that were different from the wild-type strain and thus may be further candidate ORFs involved in yeast lipid metabolism...
  5. ncbi Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex
    Zhiying Zou
    Center for Cardiovascular Sciences, Albany Medical College MC 8, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Biol Chem 278:16414-22. 2003
    ..Multicopy extragenic suppressors were selected in strains carrying deletions in FAA1 and FAA4 or FAA1 and FAT1. Each strain is unable to grow under synthetic lethal conditions when exogenous long-chain fatty acids are required,..
  6. ncbi Topology of the yeast fatty acid transport protein Fat1p: mechanistic implications for functional domains on the cytosolic surface of the plasma membrane
    Thomas Obermeyer
    Center for Metabolic Disease, Ordway Research Institute, Albany Medical College, Albany, NY 12208, USA
    J Lipid Res 48:2354-64. 2007
    ..This topological orientation is consistent with the mechanistic roles of both Fat1p and Faa1p or Faa4p in the coupled transport/activation of exogenous fatty acids by vectorial acylation...
  7. ncbi Murine FATP alleviates growth and biochemical deficiencies of yeast fat1Delta strains
    C C DiRusso
    Center for Cardiovascular Sciences, Albany Medical College, NY 12208 3479, USA
    Eur J Biochem 267:4422-33. 2000
    ..The FAT1 gene encodes a protein, Fat1p, which is required for maximal levels of fatty-acid import and has an acyl CoA ..

Research Grants11

  1. Acyl-CoA synthetase ACSVL3 in Malignant Glioma: Metabolism and Oncogenic Cellular
    Paul Watkins; Fiscal Year: 2009
    ..Results of these studies will provide a critical assessment of the mechanism by which this enzyme contributes to the malignant phenotype, and the potential therapeutic benefit of targeting this enzyme in glioma. ..
  2. XALD: Role of Very Long Chain Fatty Acyl-CoA Synthetases
    Paul Watkins; Fiscal Year: 2006
    ..Furthermore, they will facilitate elucidation of the role of enzymes belonging to the VLACS or BG families in XALD. ..
  3. Brain Uptake and Utilization of Fatty Acids and Lipids
    Paul Watkins; Fiscal Year: 2004
    ..Mol. Neurosci., which has committed to publish the proceedings of the proposed meeting. ..
  4. XALD--ROLE OF VERY LONG CHAIN FATTY ACYL COA SYNTHETASES
    Paul Watkins; Fiscal Year: 2002
    ..abstract_text> ..
  5. Acyl-CoA synthetase ACSVL3 in Malignant Glioma: Metabolism and Oncogenic Cellular
    Paul A Watkins; Fiscal Year: 2010
    ..Results of these studies will provide a critical assessment of the mechanism by which this enzyme contributes to the malignant phenotype, and the potential therapeutic benefit of targeting this enzyme in glioma. ..