Gene Symbol: zraR
Description: fused DNA-binding response regulator in two-component regulatory system with ZraS: response regulator/sigma54 interaction protein
Alias: ECK3996, JW3968, hydG
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A. Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli. J Biol Chem. 2005;280:1448-56 pubmed
    ..CreC, CusS, HydH, RstB, YedV, and YfhK), and a total of 34 RRs, including putative RRs (BaeR, BasR, CreB, CusR, HydG, RstA, YedW, YfhA, YgeK, and YhjB), have been suggested to exist in Escherichia coli...
  2. Peterson J, Chopra A, Prasad R. Fine mapping of the rrnE, purHD, and hydGH operons on the Escherichia coli chromosome. J Bacteriol. 1991;173:3274-5 pubmed
  3. Stock J, Stock A, Mottonen J. Signal transduction in bacteria. Nature. 1990;344:395-400 pubmed publisher
    ..This phosphotransfer network couples environmental signals to an array of response elements that control cell motility and regulate gene expression...
  4. Stoker K, Reijnders W, Oltmann L, Stouthamer A. Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12. J Bacteriol. 1989;171:4448-56 pubmed
    ..A single type of gene, designated hydG, was isolated...
  5. Pao G, Saier M. Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution. J Mol Evol. 1995;40:136-54 pubmed
    ..Sequence data were correlated with structure/function when such information was available.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  6. Parkinson J. Signal transduction schemes of bacteria. Cell. 1993;73:857-71 pubmed
  7. Leonhartsberger S, Huber A, Lottspeich F, Bock A. The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system. J Mol Biol. 2001;307:93-105 pubmed
    ..led to a stimulation of activation of the hycA promoter responsible for hydrogenase 3 synthesis but only when hydG is overexpressed from a plasmid in a strain lacking FhlA...
  8. McGlynn S, Ruebush S, Naumov A, Nagy L, Dubini A, King P, et al. In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation. J Biol Inorg Chem. 2007;12:443-7 pubmed
    ..expressed inactive HydA with extracts in which hydrogenase-specific maturation proteins HydE, HydF, and HydG are expressed in concert...
  9. Parkinson J, Kofoid E. Communication modules in bacterial signaling proteins. Annu Rev Genet. 1992;26:71-112 pubmed

More Information


  1. Lee L, Barrett J, Poole R. Genome-wide transcriptional response of chemostat-cultured Escherichia coli to zinc. J Bacteriol. 2005;187:1124-34 pubmed
    ..up-regulated by Zn stress, including genes known to be involved in Zn tolerance, particularly zntA, zraP, and hydG. Microarray transcriptome profiling was confirmed by real-time PCR determinations of cusF (involved in Ag and Cu ..
  2. Schumacher J, Joly N, Rappas M, Zhang X, Buck M. Structures and organisation of AAA+ enhancer binding proteins in transcriptional activation. J Struct Biol. 2006;156:190-9 pubmed
    ..available: heptameric AAA+ domains of NtrC1 and dimeric NtrC1 with its regulatory domain, hexameric AAA+ domains of ZraR with DNA binding domains, apo and nucleotide bound forms of the AAA+ domain of PspF as well as a cryo-EM structure ..
  3. Kuchenreuther J, Britt R, Swartz J. New insights into [FeFe] hydrogenase activation and maturase function. PLoS ONE. 2012;7:e45850 pubmed publisher
    ..The HydE, HydF, and HydG maturases assist in assembling the H-cluster and maturing hydrogenases into their catalytically active form...