Gene Symbol: zraP
Description: Zn-dependent periplasmic chaperone
Alias: ECK3994, JW5546, yjaI, zra
Species: Escherichia coli str. K-12 substr. MG1655
Noll M, Petrukhin K, Lutsenko S. Identification of a novel transcription regulator from Proteus mirabilis, PMTR, revealed a possible role of YJAI protein in balancing zinc in Escherichia coli. J Biol Chem. 1998;273:21393-401 pubmed
..The 12-kDa protein was identified as the C-terminal fragment of E. coli protein YJAI, and was shown to contain two zinc-binding motifs...
Leonhartsberger S, Huber A, Lottspeich F, Bock A. The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system. J Mol Biol. 2001;307:93-105 pubmed
..Expression of zraP, a gene inversely oriented to hydH/G whose product seems to be involved in acquisition of tolerance to high Zn(2+) ..
Lee L, Barrett J, Poole R. Genome-wide transcriptional response of chemostat-cultured Escherichia coli to zinc. J Bacteriol. 2005;187:1124-34 pubmed
..significantly up-regulated by Zn stress, including genes known to be involved in Zn tolerance, particularly zntA, zraP, and hydG...
Petit HÃ¤rtlein I, Rome K, de Rosny E, Molton F, Duboc C, Gueguen E, et al
. Biophysical and physiological characterization of ZraP from Escherichia coli, the periplasmic accessory protein of the atypical ZraSR two-component system. Biochem J. 2015;472:205-16 pubmed publisher
..This system controls the expression of the accessory protein ZraP that would be a periplasmic zinc scavenger...
Ravikumar S, Yoo I, Lee S, Hong S. A study on the dynamics of the zraP gene expression profile and its application to the construction of zinc adsorption bacteria. Bioprocess Biosyst Eng. 2011;34:1119-26 pubmed publisher
..These results indicate that the engineered bacterial strain developed in the present study can sense the specific heavy metal and activates a cell surface display system that acts to remove the metal. ..
Sevcenco A, Pinkse M, Wolterbeek H, Verhaert P, Hagen W, Hagedoorn P. Exploring the microbial metalloproteome using MIRAGE. Metallomics. 2011;3:1324-30 pubmed publisher
..The zinc proteome of E. coli experiencing zinc stress was dominated by ZraP, a putative zinc storage protein.