Gene Symbol: zinT
Description: zinc and cadmium binding protein, periplasmic
Alias: ECK1969, JW1956, yodA
Species: Escherichia coli str. K-12 substr. MG1655
Products:     zinT

Top Publications

  1. Laurent Winter C, Ngo S, Danchin A, Bertin P. Role of Escherichia coli histone-like nucleoid-structuring protein in bacterial metabolism and stress response--identification of targets by two-dimensional electrophoresis. Eur J Biochem. 1997;244:767-73 pubmed
    ..Finally, synthesis of several proteins belonging to the heat-shock regulon, more particularly molecular chaperones, was induced in an hns mutant. ..
  2. Puskárová A, Ferianc P, Kormanec J, Homerova D, Farewell A, Nystrom T. Regulation of yodA encoding a novel cadmium-induced protein in Escherichia coli. Microbiology. 2002;148:3801-11 pubmed
    ..One of the latter proteins was previously identified as the product of the Escherichia coli yodA ORF...
  3. Ferianc P, Farewell A, Nystrom T. The cadmium-stress stimulon of Escherichia coli K-12. Microbiology. 1998;144 ( Pt 4):1045-50 pubmed
    ..The role of the CDPs is discussed in view of their physiological assignments in the cell. ..
  4. Birch R, O Byrne C, Booth I, Cash P. Enrichment of Escherichia coli proteins by column chromatography on reactive dye columns. Proteomics. 2003;3:764-76 pubmed
    ..levels of expression were observed for a number of proteins (for example, GdhA, PanC, ProC, TkrA, EF-TS and YodA) were observed for E. coli grown at pH 5.8...
  5. David G, Blondeau K, Schiltz M, Penel S, Lewit Bentley A. YodA from Escherichia coli is a metal-binding, lipocalin-like protein. J Biol Chem. 2003;278:43728-35 pubmed
    We have determined the crystal structure of YodA, an Escherichia coli protein of unknown function. YodA had been identified under conditions of cadmium stress, and we confirm that it binds metals such as cadmium and zinc...
  6. Kershaw C, Brown N, Hobman J. Zinc dependence of zinT (yodA) mutants and binding of zinc, cadmium and mercury by ZinT. Biochem Biophys Res Commun. 2007;364:66-71 pubmed
    b>ZinT (B1973), previously known as YodA, was originally characterised as a cadmium-induced periplasmic protein under the regulation of Fur and SoxS...
  7. Stojnev T, Harichova J, Ferianc P, Nystrom T. Function of a novel cadmium-induced yodA protein in Escherichia coli. Curr Microbiol. 2007;55:99-104 pubmed
    ..This protein was previously identified as the product of the E. coli yodA open reading frame. We now report the isolation of an E...
  8. Graham A, Hunt S, Stokes S, Bramall N, Bunch J, Cox A, et al. Severe zinc depletion of Escherichia coli: roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins. J Biol Chem. 2009;284:18377-89 pubmed publisher
    ..05) in cells from Zn(2+)-deficient chemostats, including zinT (yodA). zinT is shown to be regulated by Zur (zinc uptake regulator)...
  9. David G, Blondeau K, Renouard M, Lewit Bentley A. Crystallization and preliminary analysis of Escherichia coli YodA. Acta Crystallogr D Biol Crystallogr. 2002;58:1243-5 pubmed
    The Escherichia coli protein YodA was overexpressed, purified and crystallized in several crystal forms. The function of this protein is not known, although it has been identified under conditions of bacterial stress...

More Information


  1. Panina E, Mironov A, Gelfand M. Comparative genomics of bacterial zinc regulons: enhanced ion transport, pathogenesis, and rearrangement of ribosomal proteins. Proc Natl Acad Sci U S A. 2003;100:9912-7 pubmed publisher
    ..and their paralogs, zinc regulons were predicted to contain a candidate component of the ATP binding cassette, zinT (b1995 in Escherichia coli and yrpE in Bacillus subtilis)...
  2. Kannan G, Wilks J, Fitzgerald D, Jones B, Bondurant S, Slonczewski J. Rapid acid treatment of Escherichia coli: transcriptomic response and recovery. BMC Microbiol. 2008;8:37 pubmed publisher
    ..yneI) were up-regulated specifically by external acidification, while other genes (fimB, ygaC, yhcN, yhjX, ymgABC, yodA) presented a benzoate response consistent with cytoplasmic pH stress...