ytfE

Summary

Gene Symbol: ytfE
Description: iron-sulfur cluster repair protein RIC
Alias: ECK4205, JW4167, dnrN
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Brunskill E, de Jonge B, Bayles K. The Staphylococcus aureus scdA gene: a novel locus that affects cell division and morphogenesis. Microbiology. 1997;143 ( Pt 9):2877-82 pubmed publisher
    ..Furthermore, KB323 exhibited a reduced rate of autolysis and had increased peptidoglycan cross-linking compared to the parental strain, NCTC 8325-4. These data suggest that scdA plays an important role in staphylococcal cell division...
  2. Justino M, Vicente J, Teixeira M, Saraiva L. New genes implicated in the protection of anaerobically grown Escherichia coli against nitric oxide. J Biol Chem. 2005;280:2636-43 pubmed
    ..coli K-12 genes conferring anaerobic resistance to nitric oxide is presented, namely the gene product of YtfE and a potential transcriptional regulator of the helix-turn-helix LysR-type (YidZ)...
  3. Justino M, Almeida C, Gonçalves V, Teixeira M, Saraiva L. Escherichia coli YtfE is a di-iron protein with an important function in assembly of iron-sulphur clusters. FEMS Microbiol Lett. 2006;257:278-84 pubmed
    Our previous analysis of the transcriptome of Escherichia coli under nitrosative stress showed that the ytfE gene was one of the highest induced genes. Furthermore, the E...
  4. Justino M, Almeida C, Teixeira M, Saraiva L. Escherichia coli di-iron YtfE protein is necessary for the repair of stress-damaged iron-sulfur clusters. J Biol Chem. 2007;282:10352-9 pubmed
    DNA microarray experiments showed that the expression of the Escherichia coli ytfE gene is highly increased upon exposure to nitric oxide. We also reported that deletion of ytfE significantly alters the phenotype of E...
  5. Overton T, Justino M, Li Y, Baptista J, Melo A, Cole J, et al. Widespread distribution in pathogenic bacteria of di-iron proteins that repair oxidative and nitrosative damage to iron-sulfur centers. J Bacteriol. 2008;190:2004-13 pubmed publisher
    Expression of two genes of unknown function, Staphylococcus aureus scdA and Neisseria gonorrhoeae dnrN, is induced by exposure to oxidative or nitrosative stress...
  6. Todorovic S, Justino M, Wellenreuther G, Hildebrandt P, Murgida D, Meyer Klaucke W, et al. Iron-sulfur repair YtfE protein from Escherichia coli: structural characterization of the di-iron center. J Biol Inorg Chem. 2008;13:765-70 pubmed publisher
    b>YtfE was recently shown to be a newly discovered protein required for the recovery of the activity of iron-sulfur-containing enzymes damaged by oxidative and nitrosative stress conditions...
  7. Bodenmiller D, Spiro S. The yjeB (nsrR) gene of Escherichia coli encodes a nitric oxide-sensitive transcriptional regulator. J Bacteriol. 2006;188:874-81 pubmed
    ..We identify here the product of the yjeB gene as a negative regulator of the transcription of the ytfE, hmpA and ygbA genes, all of which are known to be upregulated by nitrosative stress...
  8. Filenko N, Spiro S, Browning D, Squire D, Overton T, Cole J, et al. The NsrR regulon of Escherichia coli K-12 includes genes encoding the hybrid cluster protein and the periplasmic, respiratory nitrite reductase. J Bacteriol. 2007;189:4410-7 pubmed
    ..revealed that NsrR represses nine operons encoding 20 genes in Escherichia coli MG1655, including the hmpA, ytfE, and ygbA genes that were previously shown to be regulated by NsrR...
  9. Partridge J, Bodenmiller D, Humphrys M, Spiro S. NsrR targets in the Escherichia coli genome: new insights into DNA sequence requirements for binding and a role for NsrR in the regulation of motility. Mol Microbiol. 2009;73:680-94 pubmed publisher
    ..By mutagenesis we confirmed that both 11 bp motifs are required for maximal NsrR repression of the ytfE promoter...

More Information

Publications13

  1. Vine C, Justino M, Saraiva L, Cole J. Detection by whole genome microarrays of a spontaneous 126-gene deletion during construction of a ytfE mutant: confirmation that a ytfE mutation results in loss of repair of iron-sulfur centres in proteins damaged by oxidative or nitrosative stress. J Microbiol Methods. 2010;81:77-9 pubmed publisher
    ..detection of a spontaneous secondary deletion of 126 genes that occurred during construction of an Escherichia coli ytfE mutant, LMS4209, explaining some of its unexpected growth defects...
  2. Nobre L, Garcia Serres R, Todorovic S, Hildebrandt P, Teixeira M, Latour J, et al. Escherichia coli RIC is able to donate iron to iron-sulfur clusters. PLoS ONE. 2014;9:e95222 pubmed publisher
    ..Altogether, these results suggest that RIC is capable of delivering iron for the formation of iron-sulfur clusters. ..
  3. Rodionov D, Dubchak I, Arkin A, Alm E, Gelfand M. Dissimilatory metabolism of nitrogen oxides in bacteria: comparative reconstruction of transcriptional networks. PLoS Comput Biol. 2005;1:e55 pubmed
    ..In enterobacteria, the regulon also includes two nitrite-responsive loci, nipAB (hcp-hcr) and nipC (dnrN), thus confirming the identity of the effector, i.e. nitrite...
  4. Efromovich S, Grainger D, Bodenmiller D, Spiro S. Genome-wide identification of binding sites for the nitric oxide-sensitive transcriptional regulator NsrR. Methods Enzymol. 2008;437:211-33 pubmed publisher
    ..Three other transcription units (ytfE, ygbA, and hcp-hcr) are known to be subject to regulation by NsrR...