Gene Symbol: ynaI
Description: mechanosensitive channel protein, very small conductance
Alias: ECK1327, JW1323
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Levina N, Tötemeyer S, Stokes N, Louis P, Jones M, Booth I. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. EMBO J. 1999;18:1730-7 pubmed
    ..In contrast, analysis of mutants of E.coli lacking YggB and MscL shows that mechanosensitive channels are designed to open at a pressure change just below that which would cause cell disruption leading to death. ..
  2. Pivetti C, Yen M, Miller S, Busch W, Tseng Y, Booth I, et al. Two families of mechanosensitive channel proteins. Microbiol Mol Biol Rev. 2003;67:66-85, table of contents pubmed
    ..The presence of a conserved residue pattern for the putative channel-forming TMSs in the MscL and MscS family proteins suggests a common structural organization, gating mechanism, and evolutionary origin. ..
  3. McLaggan D, Jones M, Gouesbet G, Levina N, Lindey S, Epstein W, et al. Analysis of the kefA2 mutation suggests that KefA is a cation-specific channel involved in osmotic adaptation in Escherichia coli. Mol Microbiol. 2002;43:521-36 pubmed
    ..The data are consistent with abnormal regulation of KefA in the presence of high K+ concentrations and either betaine or proline. ..
  4. Zheng Y, Roberts R, Kasif S. Segmentally variable genes: a new perspective on adaptation. PLoS Biol. 2004;2:E81 pubmed
    ..Discerning their function and identifying their binding partners may offer biologists new insights into the basic mechanisms of adaptation, context-dependent evolution, and the interaction between microbes and their environment. ..
  5. Edwards M, Black S, Rasmussen T, Rasmussen A, Stokes N, Stephen T, et al. Characterization of three novel mechanosensitive channel activities in Escherichia coli. Channels (Austin). 2012;6:272-81 pubmed publisher
    ..However, like many bacteria, E. coli cells possess other MscS-type genes (kefA, ybdG, ybiO, yjeP and ynaI)...
  6. Mariño Ramírez L, Minor J, Reading N, Hu J. Identification and mapping of self-assembling protein domains encoded by the Escherichia coli K-12 genome by use of lambda repressor fusions. J Bacteriol. 2004;186:1311-9 pubmed
    ..The data are available online at http://oligomers.tamu.edu/. ..