Gene Symbol: ynaI
Description: mechanosensitive channel protein, very small conductance
Alias: ECK1327, JW1323
Species: Escherichia coli str. K-12 substr. MG1655
Levina N, Tötemeyer S, Stokes N, Louis P, Jones M, Booth I. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. EMBO J. 1999;18:1730-7 pubmed
..In contrast, analysis of mutants of E.coli lacking YggB and MscL shows that mechanosensitive channels are designed to open at a pressure change just below that which would cause cell disruption leading to death. ..
Pivetti C, Yen M, Miller S, Busch W, Tseng Y, Booth I, et al
. Two families of mechanosensitive channel proteins. Microbiol Mol Biol Rev. 2003;67:66-85, table of contents pubmed
..The presence of a conserved residue pattern for the putative channel-forming TMSs in the MscL and MscS family proteins suggests a common structural organization, gating mechanism, and evolutionary origin. ..
McLaggan D, Jones M, Gouesbet G, Levina N, Lindey S, Epstein W, et al
. Analysis of the kefA2 mutation suggests that KefA is a cation-specific channel involved in osmotic adaptation in Escherichia coli. Mol Microbiol. 2002;43:521-36 pubmed
..The data are consistent with abnormal regulation of KefA in the presence of high K+ concentrations and either betaine or proline. ..
Zheng Y, Roberts R, Kasif S. Segmentally variable genes: a new perspective on adaptation. PLoS Biol. 2004;2:E81 pubmed
..Discerning their function and identifying their binding partners may offer biologists new insights into the basic mechanisms of adaptation, context-dependent evolution, and the interaction between microbes and their environment. ..
Edwards M, Black S, Rasmussen T, Rasmussen A, Stokes N, Stephen T, et al
. Characterization of three novel mechanosensitive channel activities in Escherichia coli. Channels (Austin). 2012;6:272-81 pubmed publisher
..However, like many bacteria, E. coli cells possess other MscS-type genes (kefA, ybdG, ybiO, yjeP and ynaI)...
Mariño Ramírez L, Minor J, Reading N, Hu J. Identification and mapping of self-assembling protein domains encoded by the Escherichia coli K-12 genome by use of lambda repressor fusions. J Bacteriol. 2004;186:1311-9 pubmed
..The data are available online at http://oligomers.tamu.edu/. ..