yidC

Summary

Gene Symbol: yidC
Description: membrane protein insertase
Alias: ECK3698, JW3683
Species: Escherichia coli str. K-12 substr. MG1655
Products:     yidC

Top Publications

  1. Yen M, Harley K, Tseng Y, Saier M. Phylogenetic and structural analyses of the oxa1 family of protein translocases. FEMS Microbiol Lett. 2001;204:223-31 pubmed
    ..Multiple sequence alignments reveal conserved residues and provide the basis for structural and phylogenetic analyses that serve to characterize the Oxa1 family. ..
  2. Watkins W, Menon A. Reconstitution of phospholipid flippase activity from E. coli inner membrane: a test of the protein translocon as a candidate flippase. Biol Chem. 2002;383:1435-40 pubmed
    ..To test this possibility, we used E. coli cells depleted of SecYE or YidC to assay flipping in proteoliposomes reconstituted from detergent extracts of their inner membranes...
  3. Chen M, Xie K, Jiang F, Yi L, Dalbey R. YidC, a newly defined evolutionarily conserved protein, mediates membrane protein assembly in bacteria. Biol Chem. 2002;383:1565-72 pubmed
    ..Recently, a new membrane component called YidC was discovered that mediates the insertion of proteins into membranes in bacteria...
  4. Fröderberg L, Houben E, Samuelson J, Chen M, Park S, Phillips G, et al. Versatility of inner membrane protein biogenesis in Escherichia coli. Mol Microbiol. 2003;47:1015-27 pubmed
    ..covering most IMP structures possible has been studied in a variety of signal recognition particle (SRP), Sec and YidC mutant strains. We show that the assembly of the complete set of model IMPs is assisted (i.e...
  5. Facey S, Neugebauer S, Krauss S, Kuhn A. The mechanosensitive channel protein MscL is targeted by the SRP to the novel YidC membrane insertion pathway of Escherichia coli. J Mol Biol. 2007;365:995-1004 pubmed
    ..However, depletion of the membrane insertase YidC inhibits translocation of the protein across the membrane...
  6. Jiang F, Chen M, Yi L, de Gier J, Kuhn A, Dalbey R. Defining the regions of Escherichia coli YidC that contribute to activity. J Biol Chem. 2003;278:48965-72 pubmed
    The YidC/Oxa1/Alb3 family of proteins catalyzes membrane protein insertion in bacteria, mitochondria, and chloroplasts...
  7. de Gier J, Luirink J. The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins. EMBO Rep. 2003;4:939-43 pubmed
    ..Lateral transport seems to be assisted by the IMP YidC. In this article, we discuss recent observations that point to a key role for the ribosome in IMP targeting and to ..
  8. van der Laan M, Urbanus M, Ten Hagen Jongman C, Nouwen N, Oudega B, Harms N, et al. A conserved function of YidC in the biogenesis of respiratory chain complexes. Proc Natl Acad Sci U S A. 2003;100:5801-6 pubmed
    The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IMPs both in concert with and independently from the Sec translocase...
  9. Price C, Driessen A. Conserved negative charges in the transmembrane segments of subunit K of the NADH:ubiquinone oxidoreductase determine its dependence on YidC for membrane insertion. J Biol Chem. 2010;285:3575-81 pubmed publisher
    All members of the Oxa1/Alb3/YidC family have been implicated in the biogenesis of respiratory and energy transducing proteins. In Escherichia coli, YidC functions together with and independently of the Sec system...

More Information

Publications75

  1. Wagner S, Pop O, Pop O, Haan G, Baars L, Koningstein G, et al. Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC. J Biol Chem. 2008;283:17881-90 pubmed publisher
    ..MalF is targeted via the SRP pathway to the Sec/YidC insertion site...
  2. Kol S, Nouwen N, Driessen A. Mechanisms of YidC-mediated insertion and assembly of multimeric membrane protein complexes. J Biol Chem. 2008;283:31269-73 pubmed publisher
    The YidC protein fulfills a dual and essential role in the assembly of inner membrane proteins in Escherichia coli...
  3. van der Laan M, Nouwen N, Driessen A. SecYEG proteoliposomes catalyze the Deltaphi-dependent membrane insertion of FtsQ. J Biol Chem. 2004;279:1659-64 pubmed
    ..potential are essential for the translocation of the large periplasmic domain of FtsQ, whereas co-reconstituted YidC has an inhibitory effect...
  4. van der Laan M, Houben E, Nouwen N, Luirink J, Driessen A. Reconstitution of Sec-dependent membrane protein insertion: nascent FtsQ interacts with YidC in a SecYEG-dependent manner. EMBO Rep. 2001;2:519-23 pubmed
    The inner membrane protein YidC is associated with the preprotein translocase of Escherichia coli and contacts transmembrane segments of nascent inner membrane proteins during membrane insertion...
  5. Urbanus M, Scotti P, Froderberg L, Saaf A, de Gier J, Brunner J, et al. Sec-dependent membrane protein insertion: sequential interaction of nascent FtsQ with SecY and YidC. EMBO Rep. 2001;2:524-9 pubmed
    Recent studies identified YidC as a novel membrane factor that may play a key role in membrane insertion of inner membrane proteins (IMPs), both in conjunction with the Sec-translocase and as a separate entity...
  6. Raine A, Ullers R, Pavlov M, Luirink J, Wikberg J, Ehrenberg M. Targeting and insertion of heterologous membrane proteins in E. coli. Biochimie. 2003;85:659-68 pubmed
    ..Furthermore, we demonstrate that nascent chains of Bop and MC(4)R first interact with SecY and then with YidC as they move through the translocon...
  7. Price C, Driessen A. YidC is involved in the biogenesis of anaerobic respiratory complexes in the inner membrane of Escherichia coli. J Biol Chem. 2008;283:26921-7 pubmed publisher
    b>YidC of Escherichia coli belongs to the evolutionarily conserved Oxa1/Alb3/YidC family. Members of this family have all been implicated in membrane protein biogenesis of aerobic respiratory and energy-transducing proteins...
  8. Samuelson J, Jiang F, Yi L, Chen M, de Gier J, Kuhn A, et al. Function of YidC for the insertion of M13 procoat protein in Escherichia coli: translocation of mutants that show differences in their membrane potential dependence and Sec requirement. J Biol Chem. 2001;276:34847-52 pubmed
    ..M13 Procoat protein in bacteria requires the membrane electrochemical potential and the integral membrane protein YidC. We show here that YidC is involved in the translocation but not in the targeting of the Procoat protein, because ..
  9. Saaf A, Monne M, de Gier J, von Heijne G. Membrane topology of the 60-kDa Oxa1p homologue from Escherichia coli. J Biol Chem. 1998;273:30415-8 pubmed
    ..In contrast to partial N-terminal fusion protein constructs, the full-length protein folds into a protease-resistant conformation, suggesting that important folding determinants are present in the C-terminal part of the molecule. ..
  10. van der Laan M, Bechtluft P, Kol S, Nouwen N, Driessen A. F1F0 ATP synthase subunit c is a substrate of the novel YidC pathway for membrane protein biogenesis. J Cell Biol. 2004;165:213-22 pubmed
    The Escherichia coli YidC protein belongs to the Oxa1 family of membrane proteins that have been suggested to facilitate the insertion and assembly of membrane proteins either in cooperation with the Sec translocase or as a separate ..
  11. Yi L, Jiang F, Chen M, Cain B, Bolhuis A, Dalbey R. YidC is strictly required for membrane insertion of subunits a and c of the F(1)F(0)ATP synthase and SecE of the SecYEG translocase. Biochemistry. 2003;42:10537-44 pubmed
    b>YidC was previously discovered to play a critical role for the insertion of the Sec-independent M13 procoat and Pf3 coat phage proteins into the Escherichia coli inner membrane...
  12. Jiang F, Yi L, Moore M, Chen M, Rohl T, van Wijk K, et al. Chloroplast YidC homolog Albino3 can functionally complement the bacterial YidC depletion strain and promote membrane insertion of both bacterial and chloroplast thylakoid proteins. J Biol Chem. 2002;277:19281-8 pubmed
    A new component of the bacterial translocation machinery, YidC, has been identified that specializes in the integration of membrane proteins...
  13. Serek J, Bauer Manz G, Struhalla G, van den Berg L, Kiefer D, Dalbey R, et al. Escherichia coli YidC is a membrane insertase for Sec-independent proteins. EMBO J. 2004;23:294-301 pubmed
    b>YidC is a recently discovered bacterial membrane protein that is related to the mitochondrial Oxa1p and the Alb3 protein of chloroplasts...
  14. Yi L, Celebi N, Chen M, Dalbey R. Sec/SRP requirements and energetics of membrane insertion of subunits a, b, and c of the Escherichia coli F1F0 ATP synthase. J Biol Chem. 2004;279:39260-7 pubmed
    Previously, the role of YidC in the membrane protein biogenesis of the F(0) sector of the Escherichia coli F(1)F(0) ATP synthase was investigated...
  15. van Bloois E, Nagamori S, Koningstein G, Ullers R, Preuss M, Oudega B, et al. The Sec-independent function of Escherichia coli YidC is evolutionary-conserved and essential. J Biol Chem. 2005;280:12996-3003 pubmed
    b>YidC plays a role in the integration and assembly of many (if not all) Escherichia coli inner membrane proteins...
  16. Yi L, Dalbey R. Oxa1/Alb3/YidC system for insertion of membrane proteins in mitochondria, chloroplasts and bacteria (review). Mol Membr Biol. 2005;22:101-11 pubmed
    ..In this pathway, the Oxa1/Alb3/YidC proteins are believed to function as membrane insertases that play an important role in the membrane protein ..
  17. Facey S, Kuhn A. The sensor protein KdpD inserts into the Escherichia coli membrane independent of the Sec translocase and YidC. Eur J Biochem. 2003;270:1724-34 pubmed
    ..The results show that neither the Sec translocase nor the YidC protein are required for membrane insertion of the second loop of KdpD...
  18. Houben E, Urbanus M, van der Laan M, ten Hagen Jongman C, Driessen A, Brunner J, et al. YidC and SecY mediate membrane insertion of a Type I transmembrane domain. J Biol Chem. 2002;277:35880-6 pubmed
    b>YidC has been identified recently as an evolutionary conserved factor that is involved in the integration of inner membrane proteins (IMPs) in Escherichia coli...
  19. Kuhn A, Stuart R, Henry R, Dalbey R. The Alb3/Oxa1/YidC protein family: membrane-localized chaperones facilitating membrane protein insertion?. Trends Cell Biol. 2003;13:510-6 pubmed
    The recently identified Alb3/Oxa1/YidC family constitutes a novel class of proteins that function in promoting membrane insertion in chloroplasts, mitochondria and bacteria...
  20. Scotti P, Urbanus M, Brunner J, de Gier J, von Heijne G, van der Does C, et al. YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase. EMBO J. 2000;19:542-9 pubmed
    ..signal anchor sequence contacts both lipids and a novel 60 kDa translocase-associated component that we identify as YidC. YidC is homologous to Saccharomyces cerevisiae Oxa1p, which has been shown to function in a novel export pathway ..
  21. Nagamori S, Smirnova I, Kaback H. Role of YidC in folding of polytopic membrane proteins. J Cell Biol. 2004;165:53-62 pubmed
    b>YidC of Echerichia coli, a member of the conserved Alb3/Oxa1/YidC family, is postulated to be important for biogenesis of membrane proteins...
  22. Urbanus M, Fröderberg L, Drew D, Bjork P, de Gier J, Brunner J, et al. Targeting, insertion, and localization of Escherichia coli YidC. J Biol Chem. 2002;277:12718-23 pubmed
    b>YidC was recently shown to play an important role in the assembly of inner membrane proteins (IMPs) both in conjunction with and separate from the Sec-translocon...
  23. Stuart R, Neupert W. Making membranes in bacteria. Nature. 2000;406:575, 577 pubmed
  24. Lotz M, Haase W, Kuhlbrandt W, Collinson I. Projection structure of yidC: a conserved mediator of membrane protein assembly. J Mol Biol. 2008;375:901-7 pubmed
    ..In Escherichia coli, yidC is required for membrane insertion, acting in both a Sec-dependent and a Sec-independent manner...
  25. Stuart R. Insertion of proteins into the inner membrane of mitochondria: the role of the Oxa1 complex. Biochim Biophys Acta. 2002;1592:79-87 pubmed
    ..Oxa1 is a member of the conserved Oxa1/YidC/Alb3 protein family found throughout prokaryotes throughout eukaryotes (where it is found in mitochondria and ..
  26. de Gier J, Luirink J. Biogenesis of inner membrane proteins in Escherichia coli. Mol Microbiol. 2001;40:314-22 pubmed
    ..Here, we review and discuss recent advances in our understanding of the biogenesis of inner membrane proteins in E. coli. ..
  27. Nouwen N, Driessen A. SecDFyajC forms a heterotetrameric complex with YidC. Mol Microbiol. 2002;44:1397-405 pubmed
    ..SecD, SecF, and YajC form another heterotrimeric complex that can associate with the SecYEG complex. YidC is an essential membrane protein that plays a role in the integration of newly synthesized membrane proteins, and ..
  28. Chen M, Samuelson J, Jiang F, Muller M, Kuhn A, Dalbey R. Direct interaction of YidC with the Sec-independent Pf3 coat protein during its membrane protein insertion. J Biol Chem. 2002;277:7670-5 pubmed
    b>YidC is a newly defined translocase component that mediates the insertion of proteins into the membrane bilayer. How YidC functions in the insertion process is not known...
  29. Beck K, Eisner G, Trescher D, Dalbey R, Brunner J, Muller M. YidC, an assembly site for polytopic Escherichia coli membrane proteins located in immediate proximity to the SecYE translocon and lipids. EMBO Rep. 2001;2:709-14 pubmed
    Like its mitochondrial homolog Oxa1p, the inner membrane protein YidC of Escherichia coli is involved in the integration of membrane proteins. We have analyzed individual insertion steps of the polytopic E...
  30. Luirink J, Samuelsson T, de Gier J. YidC/Oxa1p/Alb3: evolutionarily conserved mediators of membrane protein assembly. FEBS Lett. 2001;501:1-5 pubmed
    ..This factor is designated YidC in Escherichia coli, and is localized in the inner membrane...
  31. Samuelson J, Chen M, Jiang F, Moller I, Wiedmann M, Kuhn A, et al. YidC mediates membrane protein insertion in bacteria. Nature. 2000;406:637-41 pubmed
    ..Here we show that membrane insertion of two Sec-independent proteins requires YidC. YidC is essential for E. coli viability and homologues are present in mitochondria and chloroplasts...
  32. Houben E, Scotti P, Valent Q, Brunner J, de Gier J, Oudega B, et al. Nascent Lep inserts into the Escherichia coli inner membrane in the vicinity of YidC, SecY and SecA. FEBS Lett. 2000;476:229-33 pubmed
    ..Lep 100-mer was in the vicinity of SecA and SecY, whereas the first transmembrane domain H1 was in the vicinity of YidC. These results suggested that YidC, together with the Sec translocase, functions in the assembly of Lep...
  33. van Bloois E, Dekker H, Fröderberg L, Houben E, Urbanus M, de Koster C, et al. Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins. FEBS Lett. 2008;582:1419-24 pubmed publisher
    ..Here, we demonstrate that YidC and FtsH are adjacent to a nascent, truncated membrane protein using in vitro photo cross-linking...
  34. Gray A, Henderson Frost J, Boyd D, Sharafi S, Shirafi S, Niki H, et al. Unbalanced charge distribution as a determinant for dependence of a subset of Escherichia coli membrane proteins on the membrane insertase YidC. MBio. 2011;2: pubmed publisher
    ..To function properly, they must be inserted into the membrane and folded correctly. YidC, an essential protein in Escherichia coli with homologues in other bacteria, Archaea, mitochondria, and ..
  35. Wagner S, Baars L, Ytterberg A, Klussmeier A, Wagner C, Nord O, et al. Consequences of membrane protein overexpression in Escherichia coli. Mol Cell Proteomics. 2007;6:1527-50 pubmed
    ..Therefore, we analyzed the consequences of overexpression of three different membrane proteins (YidC, YedZ, and LepI) fused to green fluorescent protein (GFP) in the bacterium Escherichia coli and compared this with ..
  36. Zhu L, Wasey A, White S, Dalbey R. Charge composition features of model single-span membrane proteins that determine selection of YidC and SecYEG translocase pathways in Escherichia coli. J Biol Chem. 2013;288:7704-16 pubmed publisher
    ..of single-span model membrane proteins based upon leader peptidase that determines whether the proteins insert by a YidC/Sec-independent, YidC-only, or YidC/Sec mechanism...
  37. Pogliano K, Beckwith J. Genetic and molecular characterization of the Escherichia coli secD operon and its products. J Bacteriol. 1994;176:804-14 pubmed
    ..TnphoA fusions to SecD and SecF have also been recombined onto the chromosome and used to determine the level of these proteins within the cell. Our results indicate that there are fewer than 30 SecD and SecF molecules per cell...
  38. Yuan J, Phillips G, Dalbey R. Isolation of cold-sensitive yidC mutants provides insights into the substrate profile of the YidC insertase and the importance of transmembrane 3 in YidC function. J Bacteriol. 2007;189:8961-72 pubmed
    b>YidC, a 60-kDa integral membrane protein, plays an important role in membrane protein insertion in bacteria. YidC can function together with the SecYEG machinery or operate independently as a membrane protein insertase...
  39. Danese P, Silhavy T. Targeting and assembly of periplasmic and outer-membrane proteins in Escherichia coli. Annu Rev Genet. 1998;32:59-94 pubmed
    ..We also discuss the various signal transduction systems that monitor extracytoplasmic protein folding and targeting, and we consider how these signal transduction systems may ultimately control these processes. ..
  40. van Dalen A, van der Laan M, Driessen A, Killian J, de Kruijff B. Components required for membrane assembly of newly synthesized K+ channel KcsA. FEBS Lett. 2002;511:51-8 pubmed
    ..In the absence of YidC or at reduced SecYEG levels, KcsA assembly occurs with lower efficiency...
  41. Zhu L, Klenner C, Kuhn A, Dalbey R. Both YidC and SecYEG are required for translocation of the periplasmic loops 1 and 2 of the multispanning membrane protein TatC. J Mol Biol. 2012;424:354-67 pubmed publisher
    ..While translocation of loops 1 and 2 is strictly dependent on the Sec translocase and the YidC insertase, translocation of loop 3 does not depend on the translocase or insertase...
  42. Pogliano J, Beckwith J. SecD and SecF facilitate protein export in Escherichia coli. EMBO J. 1994;13:554-61 pubmed
    ..Our results provide additional support for the notion that an early step in protein export is cold-sensitive. ..
  43. Boy D, Koch H. Visualization of distinct entities of the SecYEG translocon during translocation and integration of bacterial proteins. Mol Biol Cell. 2009;20:1804-15 pubmed publisher
    ..in two complexes of 250 and 600 kDa, each containing both SecY and the translocon-associated membrane protein YidC. The appearance of both complexes was correlated with the number of transmembrane domains that were exposed during ..
  44. Chen Y, Soman R, Shanmugam S, Kuhn A, Dalbey R. The role of the strictly conserved positively charged residue differs among the Gram-positive, Gram-negative, and chloroplast YidC homologs. J Biol Chem. 2014;289:35656-67 pubmed publisher
    ..we investigated the importance of the conserved positively charged residue for the function of the Escherichia coli YidC, Streptococcus mutans YidC2, and the chloroplast Arabidopsis thaliana Alb3. Like the Gram-positive B...
  45. Houben E, Zarivach R, Oudega B, Luirink J. Early encounters of a nascent membrane protein: specificity and timing of contacts inside and outside the ribosome. J Cell Biol. 2005;170:27-35 pubmed
    ..particle (SRP) started to interact with the nascent IMP and to target the ribosome-nascent chain complex to the Sec-YidC complex in the inner membrane when maximally half of the transmembrane domain (TM) was exposed from the ribosomal ..
  46. Ravaud S, Stjepanovic G, Wild K, Sinning I. The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC contains a substrate binding cleft. J Biol Chem. 2008;283:9350-8 pubmed publisher
    ..b>YidC is an essential membrane protein involved in the insertion of inner membrane proteins together with the Sec ..
  47. van der Sluis E, Driessen A. Stepwise evolution of the Sec machinery in Proteobacteria. Trends Microbiol. 2006;14:105-8 pubmed
    ..The Sec machinery of Escherichia coli and other Enterobacteriales represents the end product of this stepwise evolution. ..
  48. Koch H, Moser M, Schimz K, Muller M. The integration of YidC into the cytoplasmic membrane of Escherichia coli requires the signal recognition particle, SecA and SecYEG. J Biol Chem. 2002;277:5715-8 pubmed
    The integration of the polytopic membrane protein YidC into the inner membrane of Escherichia coli was analyzed employing an in vitro system...
  49. Klenner C, Yuan J, Dalbey R, Kuhn A. The Pf3 coat protein contacts TM1 and TM3 of YidC during membrane biogenesis. FEBS Lett. 2008;582:3967-72 pubmed publisher
    The coat protein of bacteriophage Pf3 is inserted into the plasma membrane of Escherichia coli by the insertase YidC. To identify which of the six transmembrane regions of YidC bind the single-spanning Pf3 coat protein during membrane ..
  50. Yu Z, Bekker M, Tramonti A, Cook G, van Ulsen P, Scheffers D, et al. Activators of the glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli. J Bacteriol. 2011;193:1308-16 pubmed publisher
    The function of the essential inner membrane protein (IMP) YidC in Escherichia coli has been studied for a limited number of model IMPs and primarily using targeted approaches...
  51. Berrier C, Guilvout I, Bayan N, Park K, Mesneau A, Chami M, et al. Coupled cell-free synthesis and lipid vesicle insertion of a functional oligomeric channel MscL MscL does not need the insertase YidC for insertion in vitro. Biochim Biophys Acta. 2011;1808:41-6 pubmed publisher
    ..The MscL protein, a polypeptide of 136 residues, was recently shown to require YidC to be inserted in the inner membrane of E. coli...
  52. de Sousa Borges A, de Keyzer J, Driessen A, Scheffers D. The Escherichia coli membrane protein insertase YidC assists in the biogenesis of penicillin binding proteins. J Bacteriol. 2015;197:1444-50 pubmed publisher
    ..The Sec translocon and the YidC insertase are responsible for the insertion of the majority of proteins into the cytoplasmic membrane...
  53. Soman R, Yuan J, Kuhn A, Dalbey R. Polarity and charge of the periplasmic loop determine the YidC and sec translocase requirement for the M13 procoat lep protein. J Biol Chem. 2014;289:1023-32 pubmed publisher
    During membrane biogenesis, the M13 procoat protein is inserted into the lipid bilayer in a strictly YidC-dependent manner with both the hydrophobic signal sequence and the membrane anchor sequence promoting translocation of the ..
  54. Kedrov A, Wickles S, Crevenna A, van der Sluis E, Buschauer R, Berninghausen O, et al. Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis. Cell Rep. 2016;17:2943-2954 pubmed publisher
    Members of the YidC/Oxa1/Alb3 family universally facilitate membrane protein biogenesis, via mechanisms that have thus far remained unclear...
  55. Kol S, Turrell B, de Keyzer J, van der Laan M, Nouwen N, Driessen A. YidC-mediated membrane insertion of assembly mutants of subunit c of the F1F0 ATPase. J Biol Chem. 2006;281:29762-8 pubmed
    b>YidC is a member of the OxaI family of membrane proteins that has been implicated in the membrane insertion of inner membrane proteins in Escherichia coli...
  56. Wang P, Kuhn A, Dalbey R. Global change of gene expression and cell physiology in YidC-depleted Escherichia coli. J Bacteriol. 2010;192:2193-209 pubmed publisher
    b>YidC depletion affects membrane protein insertion and leads to a defect in the growth of the Escherichia coli cell...
  57. Martinez Molina D, Lundbäck A, Niegowski D, Eshaghi S. Expression and purification of the recombinant membrane protein YidC: a case study for increased stability and solubility. Protein Expr Purif. 2008;62:49-52 pubmed publisher
    b>YidC is an inner membrane protein from Escherichia coli and is an essential component in insertion, translocation and assembly of membrane proteins in the membranes...
  58. Dalbey R, Kuhn A. YidC family members are involved in the membrane insertion, lateral integration, folding, and assembly of membrane proteins. J Cell Biol. 2004;166:769-74 pubmed
    Members of the YidC family exist in all three domains of life, where they control the assembly of a large variety of membrane protein complexes that function as transporters, energy devices, or sensor proteins...
  59. Oliver D, Paetzel M. Crystal structure of the major periplasmic domain of the bacterial membrane protein assembly facilitator YidC. J Biol Chem. 2008;283:5208-16 pubmed
    The essential bacterial membrane protein YidC facilitates insertion and assembly of proteins destined for integration into the inner membrane. It has homologues in both mitochondria and chloroplasts...
  60. Yuan J, Zweers J, van Dijl J, Dalbey R. Protein transport across and into cell membranes in bacteria and archaea. Cell Mol Life Sci. 2010;67:179-99 pubmed publisher
    In the three domains of life, the Sec, YidC/Oxa1, and Tat translocases play important roles in protein translocation across membranes and membrane protein insertion...
  61. Kohler R, Boehringer D, Greber B, Bingel Erlenmeyer R, Collinson I, Schaffitzel C, et al. YidC and Oxa1 form dimeric insertion pores on the translating ribosome. Mol Cell. 2009;34:344-53 pubmed publisher
    The YidC/Oxa1/Alb3 family of membrane proteins facilitates the insertion and assembly of membrane proteins in bacteria, mitochondria, and chloroplasts...
  62. Gardel C, Benson S, Hunt J, Michaelis S, Beckwith J. secD, a new gene involved in protein export in Escherichia coli. J Bacteriol. 1987;169:1286-90 pubmed
    ..A plasmid carrying secD+ was identified and used to show that the mutations are recessive. The secD gene may code for a component of the cellular export machinery. ..
  63. Li Z, Boyd D, Reindl M, Goldberg M. Identification of YidC residues that define interactions with the Sec Apparatus. J Bacteriol. 2014;196:367-77 pubmed publisher
    ..the membrane via the Sec apparatus with the assistance of the widely conserved essential membrane protein insertase YidC. After threading into the SecYEG translocon, transmembrane segments of nascent proteins are thought to exit the ..
  64. Luirink J, von Heijne G, Houben E, de Gier J. Biogenesis of inner membrane proteins in Escherichia coli. Annu Rev Microbiol. 2005;59:329-55 pubmed
    ..Recently, YidC has been identified as a factor that assists in the integration, folding, and assembly of IMPs both in association ..
  65. du Plessis D, Nouwen N, Driessen A. Subunit a of cytochrome o oxidase requires both YidC and SecYEG for membrane insertion. J Biol Chem. 2006;281:12248-52 pubmed
    The Escherichia coli YidC protein belongs to the Oxa1 family of membrane proteins that facilitate the insertion of membrane proteins. Depletion of YidC in E...
  66. Xie K, Hessa T, Seppälä S, Rapp M, von Heijne G, Dalbey R. Features of transmembrane segments that promote the lateral release from the translocase into the lipid phase. Biochemistry. 2007;46:15153-61 pubmed
    ..reverse signal-anchor, and stop-transfer sequences in bacterial membrane proteins that use either the YidC or SecYEG translocases for membrane insertion...