yhhG

Summary

Gene Symbol: yhhG
Description: nickel responsive regulator
Species: Escherichia coli CFT073

Top Publications

  1. ncbi Isolation and characterization of the nikR gene encoding a nickel-responsive regulator in Escherichia coli
    K De Pina
    Laboratoire de Génétique Moléculaire des Microorganismes et des Interactions Cellulaires, CNRS UMR5577, Institut National des Sciences Appliquees, 69621 Villeurbanne Cedex, France
    J Bacteriol 181:670-4. 1999
  2. ncbi NikR is a ribbon-helix-helix DNA-binding protein
    P T Chivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Protein Sci 8:2494-500. 1999
  3. ncbi Nickel transport systems in microorganisms
    T Eitinger
    Humboldt Universitat zu Berlin, Institut für Biologie Mikrobiologie, Germany
    Arch Microbiol 173:1-9. 2000
  4. ncbi Regulation of high affinity nickel uptake in bacteria. Ni2+-Dependent interaction of NikR with wild-type and mutant operator sites
    P T Chivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 275:19735-41. 2000
  5. ncbi Sensing nickel. NikRs with two pockets
    John D Helmann
    Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
    Chem Biol 9:1055-7. 2002
  6. ncbi NikR repressor: high-affinity nickel binding to the C-terminal domain regulates binding to operator DNA
    Peter T Chivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Chem Biol 9:1141-8. 2002
  7. ncbi Nickel coordination is regulated by the DNA-bound state of NikR
    Paul E Carrington
    Department of Chemistry, University of Massachusetts, Amherst 01003 9336, USA
    Nat Struct Biol 10:126-30. 2003
  8. ncbi Role of an N(cap) residue in determining the stability and operator-binding affinity of Arc repressor
    Thomas A Anderson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biophys Chem 100:341-50. 2003
  9. ncbi Crystal structure of the nickel-responsive transcription factor NikR
    Eric R Schreiter
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139 USA
    Nat Struct Biol 10:794-9. 2003

Scientific Experts

  • T Eitinger
  • Robert T Sauer
  • Peter T Chivers
  • P T Chivers
  • Thomas A Anderson
  • Eric R Schreiter
  • Paul E Carrington
  • John D Helmann
  • R T Sauer
  • K De Pina
  • Catherine L Drennan
  • Michael D Sintchak
  • Michael J Maroney
  • Faizah Al-Mjeni
  • Yayi Guo
  • G Giordano
  • V Desjardin
  • L F Wu
  • M A Mandrand-Berthelot

Detail Information

Publications9

  1. ncbi Isolation and characterization of the nikR gene encoding a nickel-responsive regulator in Escherichia coli
    K De Pina
    Laboratoire de Génétique Moléculaire des Microorganismes et des Interactions Cellulaires, CNRS UMR5577, Institut National des Sciences Appliquees, 69621 Villeurbanne Cedex, France
    J Bacteriol 181:670-4. 1999
    ..Expression of nikR was partially controlled by Fnr through transcription from the nikA promoter region. In addition, a specific transcription start site for the constitutive expression of nikR was found 51 bp upstream of the nikR gene...
  2. ncbi NikR is a ribbon-helix-helix DNA-binding protein
    P T Chivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Protein Sci 8:2494-500. 1999
    ..Mutation of a residue predicted to be important for DNA-binding reduces operator affinity but does not affect the secondary structure or stability of the protein...
  3. ncbi Nickel transport systems in microorganisms
    T Eitinger
    Humboldt Universitat zu Berlin, Institut für Biologie Mikrobiologie, Germany
    Arch Microbiol 173:1-9. 2000
    ..Besides these uptake systems, different types of metal export systems, which prevent microorganisms from the toxic effects of Ni2+ at elevated intracellular concentrations, have also been described...
  4. ncbi Regulation of high affinity nickel uptake in bacteria. Ni2+-Dependent interaction of NikR with wild-type and mutant operator sites
    P T Chivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 275:19735-41. 2000
    ..In addition to both GTATGA sites and nickel, high affinity operator binding also requires the C-terminal domain of NikR...
  5. ncbi Sensing nickel. NikRs with two pockets
    John D Helmann
    Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
    Chem Biol 9:1055-7. 2002
    ..Recent results suggest that repression is elicited by binding of nickel to a high-affinity site, but a low-affinity binding pocket may also play a role...
  6. ncbi NikR repressor: high-affinity nickel binding to the C-terminal domain regulates binding to operator DNA
    Peter T Chivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Chem Biol 9:1141-8. 2002
    ..Nickel binding to a set of low-affinity NikR sites resulted in an additional large increase in operator affinity and substantially increased the size of the NikR footprint on the operator...
  7. ncbi Nickel coordination is regulated by the DNA-bound state of NikR
    Paul E Carrington
    Department of Chemistry, University of Massachusetts, Amherst 01003 9336, USA
    Nat Struct Biol 10:126-30. 2003
    ....
  8. ncbi Role of an N(cap) residue in determining the stability and operator-binding affinity of Arc repressor
    Thomas A Anderson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biophys Chem 100:341-50. 2003
    ..Based upon the results presented here, revised sequence alignments of the MetJ and NikR subfamilies with Arc and other ribbon-helix-helix proteins are proposed...
  9. ncbi Crystal structure of the nickel-responsive transcription factor NikR
    Eric R Schreiter
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139 USA
    Nat Struct Biol 10:794-9. 2003
    ..The regulatory domain of NikR contains four nickel-binding sites at the tetramer interface, each exhibiting a novel square-planar coordination by three histidines and one cysteine side chain...