Research Topics

Genomes and Genes

Gene Symbol: yhcC

Description: putative Fe-S oxidoreductase, Radical SAM superfamily protein

Alias: ECK3201, JW3178

Species: Escherichia coli str. K-12 substr. MG1655

Ernsting B, Denninger J, Blumenthal R, Matthews R. Regulation of the gltBDF operon of Escherichia coli: how is a leucine-insensitive operon regulated by the leucine-responsive regulatory protein?. J Bacteriol. 1993;175:7160-9 pubmed

..At lower concentrations of Lrp, transcription of the target gene should be sensitive to leucine. This model suggests that regulation of the concentration of active Lrp is critical to control of the Lrp regulon. ..
Sofia H, Chen G, Hetzler B, Reyes Spindola J, Miller N. Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods. Nucleic Acids Res. 2001;29:1097-106 pubmed

..Two functional predictions for unknown proteins are made based on integrating other data types such as motif, domain, operon and biochemical pathway into an organized view of similarity relationships. ..
Estellon J, Ollagnier de Choudens S, Smadja M, Fontecave M, Vandenbrouck Y. An integrative computational model for large-scale identification of metalloproteins in microbial genomes: a focus on iron-sulfur cluster proteins. Metallomics. 2014;6:1913-30 pubmed publisher

..Two newly-identified proteins, YhcC and YdiJ, were functionally validated as genuine iron-sulfur proteins, confirming the prediction...