Gene Symbol: yfbR
Description: 5'-nucleotidase
Alias: ECK2285, JW2288
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Zimmerman M, Proudfoot M, Yakunin A, Minor W. Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli. J Mol Biol. 2008;378:215-26 pubmed publisher
    ..and two complexed with natural substrates) of an HD-domain phosphohydrolase, the Escherichia coli 5'-nucleotidase YfbR. The free-state structure of YfbR contains a large cavity accommodating the metal-coordinating HD motif (H33, H68, ..
  2. Proudfoot M, Kuznetsova E, Brown G, Rao N, Kitagawa M, Mori H, et al. General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG. J Biol Chem. 2004;279:54687-94 pubmed
    ..These screens identified the presence of nucleotidase activity in three uncharacterized E. coli proteins, SurE, YfbR, and YjjG, that belong to different enzyme superfamilies: SurE-like family, HD domain family (YfbR), and haloacid ..
  3. Weiss B. The deoxycytidine pathway for thymidylate synthesis in Escherichia coli. J Bacteriol. 2007;189:7922-6 pubmed
    ..The pathway requires the gene for any of three nucleoside diphosphate kinases (ndk, pykA, or pykF) and the gene for a 5'-nucleotidase (yfbR).