Gene Symbol: yafO
Description: mRNA interferase toxin of the YafO-YafN toxin-antitoxin system
Alias: ECK0234, JW0223
Species: Escherichia coli str. K-12 substr. MG1655
McKenzie G, Magner D, Lee P, Rosenberg S. The dinB operon and spontaneous mutation in Escherichia coli. J Bacteriol. 2003;185:3972-7 pubmed
..We demonstrate the existence of a dinB operon that contains four genes, dinB-yafN-yafO-yafP. The results imply a role for yafN, yafO, and/or yafP in spontaneous mutation.
Zhang Y, Yamaguchi Y, Inouye M. Characterization of YafO, an Escherichia coli toxin. J Biol Chem. 2009;284:25522-31 pubmed publisher
b>YafO is a toxin encoded by the yafN-yafO antitoxin-toxin operon in the Escherichia coli genome. Our results show that YafO inhibits protein synthesis but not DNA or RNA synthesis...
Courcelle J, Khodursky A, Peter B, Brown P, Hanawalt P. Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli. Genetics. 2001;158:41-64 pubmed
..These newly identified UV-responsive genes are discussed with respect to their possible roles in cellular recovery following exposure to UV irradiation. ..
Faure D, Frederick R, Włoch D, Portier P, Blot M, Adams J. Genomic changes arising in long-term stab cultures of Escherichia coli. J Bacteriol. 2004;186:6437-42 pubmed
..It is speculated that the loss of the crl locus is responsible for the selective advantage of the deletions. ..
Singletary L, Gibson J, Tanner E, McKenzie G, Lee P, Gonzalez C, et al
. An SOS-regulated type 2 toxin-antitoxin system. J Bacteriol. 2009;191:7456-65 pubmed publisher
..yafN was identified as a putative antitoxin by homology to known antitoxins, implicating yafO (and/or yafP) as a putative toxin...
Christensen Dalsgaard M, Jørgensen M, Gerdes K. Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Mol Microbiol. 2010;75:333-48 pubmed publisher
..coli. We found that the yafNO, higBA (ygjNM) and ygiUT loci encode mRNA interferases related to RelE. YafO and HigB cleaved translated mRNA only, while YgiU cleaved RNA site-specifically at GC[A/U], independently of ..