Gene Symbol: yafN
Description: antitoxin of the YafO-YafN toxin-antitoxin system
Alias: ECK0233, JW0222
Species: Escherichia coli str. K-12 substr. MG1655
Gotfredsen M, Gerdes K. The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Mol Microbiol. 1998;29:1065-76 pubmed
..Indirect evidence suggests that the toxicity of RelE may be related to the inhibition of protein synthesis. Based on these observations, we propose a model that explains the delayed relaxed phenotype associated with mutations in relB. ..
Gerdes K. Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress. J Bacteriol. 2000;182:561-72 pubmed
McKenzie G, Magner D, Lee P, Rosenberg S. The dinB operon and spontaneous mutation in Escherichia coli. J Bacteriol. 2003;185:3972-7 pubmed
..mutation are resolved by the finding that mutation is reduced by a polar allele with which dinB and neighboring yafN are deleted but not by two nonpolar dinB alleles...
Zhang Y, Yamaguchi Y, Inouye M. Characterization of YafO, an Escherichia coli toxin. J Biol Chem. 2009;284:25522-31 pubmed publisher
YafO is a toxin encoded by the yafN-yafO antitoxin-toxin operon in the Escherichia coli genome. Our results show that YafO inhibits protein synthesis but not DNA or RNA synthesis...
Courcelle J, Khodursky A, Peter B, Brown P, Hanawalt P. Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli. Genetics. 2001;158:41-64 pubmed
..These newly identified UV-responsive genes are discussed with respect to their possible roles in cellular recovery following exposure to UV irradiation. ..
Christensen Dalsgaard M, Jørgensen M, Gerdes K. Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Mol Microbiol. 2010;75:333-48 pubmed publisher
..Induction of the three loci depended on Lon protease that may sense the environmental stresses and activate TA loci by cleavage of the antitoxins. Transcription of the three TA operons was autoregulated by the antitoxins. ..
Singletary L, Gibson J, Tanner E, McKenzie G, Lee P, Gonzalez C, et al
. An SOS-regulated type 2 toxin-antitoxin system. J Bacteriol. 2009;191:7456-65 pubmed publisher
..The yafNOP genes are part of the dinB operon, of which dinB underlies stress-induced mutagenesis mechanisms. yafN was identified as a putative antitoxin by homology to known antitoxins, implicating yafO (and/or yafP) as a ..