uvrY

Summary

Gene Symbol: uvrY
Description: response regulator in two-component regulatory system with BarA
Alias: ECK1913, JW1899, gacA, sirA, yecB
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Moolenaar G, Van Sluis C, Backendorf C, van de Putte P. Regulation of the Escherichia coli excision repair gene uvrC. Overlap between the uvrC structural gene and the region coding for a 24 kD protein. Nucleic Acids Res. 1987;15:4273-89 pubmed
    ..The mutant however only slightly affects the UV sensitivity of the cell. Transcription of P3 alone provides sufficient UvrC protein for the normal repair of UV lesions...
  2. Pernestig A, Georgellis D, Romeo T, Suzuki K, Tomenius H, Normark S, et al. The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources. J Bacteriol. 2003;185:843-53 pubmed
    The Escherichia coli BarA and UvrY proteins were recently demonstrated to constitute a novel two-component system, although its function has remained largely elusive...
  3. Pernestig A, Melefors O, Georgellis D. Identification of UvrY as the cognate response regulator for the BarA sensor kinase in Escherichia coli. J Biol Chem. 2001;276:225-31 pubmed publisher
    ..In this study, we report that UvrY is the cognate response regulator for BarA of Escherichia coli...
  4. Heeb S, Haas D. Regulatory roles of the GacS/GacA two-component system in plant-associated and other gram-negative bacteria. Mol Plant Microbe Interact. 2001;14:1351-63 pubmed publisher
    The sensor kinase GacS and the response regulator GacA are members of a two-component system that is present in a wide variety of gram-negative bacteria and has been studied mainly in enteric bacteria and fluorescent pseudomonads...
  5. Tomenius H, Pernestig A, Méndez Catalá C, Georgellis D, Normark S, Melefors O. Genetic and functional characterization of the Escherichia coli BarA-UvrY two-component system: point mutations in the HAMP linker of the BarA sensor give a dominant-negative phenotype. J Bacteriol. 2005;187:7317-24 pubmed
    The BarA-UvrY two-component system family is strongly associated with virulence but is poorly understood at the molecular level...
  6. Suzuki K, Wang X, Weilbacher T, Pernestig A, Melefors O, Georgellis D, et al. Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli. J Bacteriol. 2002;184:5130-40 pubmed
    ..Mutations affecting the BarA/UvrY two-component signal transduction system decreased csrB transcription but did not affect csrA'-'lacZ expression...
  7. Tomenius H, Pernestig A, Jonas K, Georgellis D, Möllby R, Normark S, et al. The Escherichia coli BarA-UvrY two-component system is a virulence determinant in the urinary tract. BMC Microbiol. 2006;6:27 pubmed
    ..enterica BarA-SirA, the Erwinia carotovora ExpS-ExpA, the Vibrio cholerae BarA-VarA and the Pseudomonas spp GacS-GacA all belong to the same orthologous family of two-component systems as the Escherichia coli BarA-UvrY...
  8. Ahmer B, van Reeuwijk J, Watson P, Wallis T, Heffron F. Salmonella SirA is a global regulator of genes mediating enteropathogenesis. Mol Microbiol. 1999;31:971-82 pubmed
    b>SirA of Salmonella typhimurium is known to regulate the hilA and prgH genes within Salmonella pathogenicity island 1 (SPI1)...
  9. Goodier R, Ahmer B. SirA orthologs affect both motility and virulence. J Bacteriol. 2001;183:2249-58 pubmed
    The sirA gene of Salmonella enterica serovar Typhimurium encodes a two-component response regulator of the FixJ family that has a positive regulatory influence on the expression of type III secretion genes involved with epithelial cell ..

More Information

Publications15

  1. Mondragón V, Franco B, Jonas K, Suzuki K, Romeo T, Melefors O, et al. pH-dependent activation of the BarA-UvrY two-component system in Escherichia coli. J Bacteriol. 2006;188:8303-6 pubmed
    The barA and uvrY genes of Escherichia coli encode a two-component sensor kinase and a response regulator, respectively...
  2. Hengge R. The two-component network and the general stress sigma factor RpoS (sigma S) in Escherichia coli. Adv Exp Med Biol. 2008;631:40-53 pubmed publisher
    ..In addition, the BarA/UvrY and Rcs phosphorelay systems can activate rpoS transcription and translation, respectively...
  3. Camacho M, Alvarez A, Chavez R, Romeo T, Merino E, Georgellis D. Effects of the global regulator CsrA on the BarA/UvrY two-component signaling system. J Bacteriol. 2015;197:983-91 pubmed publisher
    The hybrid sensor kinase BarA and its cognate response regulator UvrY, members of the two-component signal transduction family, activate transcription of CsrB and CsrC noncoding RNAs...
  4. Sharma S, Stark T, Beattie W, Moses R. Multiple control elements for the uvrC gene unit of Escherichia coli. Nucleic Acids Res. 1986;14:2301-18 pubmed
    ..The upstream region including the 28 kd protein is required for enhanced expression under non-induced conditions. These results show that the uvrC gene is controlled by multiple promoters and is transcribed as part of a multigene unit. ..
  5. Johnston C, Pegues D, Hueck C, Lee A, Miller S. Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily. Mol Microbiol. 1996;22:715-27 pubmed
    ..In this report we identify sirA, a gene located outside the pathogenicity island that is essential for induction of prgHIJK and hilA transcription...
  6. Ahmer B. Cell-to-cell signalling in Escherichia coli and Salmonella enterica. Mol Microbiol. 2004;52:933-45 pubmed
    ..The latter system has homologues in E. coli and Salmonella, as well as other bacteria, plants and animals. In fact, the protease components from Providencia and Drosophila are functionally interchangeable. ..