Gene Symbol: umpG
Description: broad specificity 5'(3')-nucleotidase and polyphosphatase
Alias: ECK2739, JW2714, surE, ygbC
Species: Escherichia coli str. K-12 substr. MG1655
Li C, Ichikawa J, Ravetto J, Kuo H, Fu J, Clarke S. A new gene involved in stationary-phase survival located at 59 minutes on the Escherichia coli chromosome. J Bacteriol. 1994;176:6015-22 pubmed
..and in high-salt media compared with parent cells containing the intact gene, and we thus designate this gene surE (survival). surE appears to be the first gene of a bicistronic operon also containing the pcm gene...
Reaves M, Young B, Hosios A, Xu Y, Rabinowitz J. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature. 2013;500:237-41 pubmed publisher
..Thus, pyrimidine homeostasis involves dual regulatory strategies, with classical feedback inhibition enhancing metabolic efficiency and directed overflow metabolism ensuring end-product homeostasis...
Visick J, Ichikawa J, Clarke S. Mutations in the Escherichia coli surE gene increase isoaspartyl accumulation in a strain lacking the pcm repair methyltransferase but suppress stress-survival phenotypes. FEMS Microbiol Lett. 1998;167:19-25 pubmed
The Escherichia coli surE gene is co-transcribed with pcm, encoding the L-isoaspartyl protein repair methyltransferase, and is highly conserved among both the Eubacteria and the Archaea; however, no biochemical function has yet been ..
Lee J, Kwak J, Moon J, Eom S, Liong E, Pedelacq J, et al
. Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family. Nat Struct Biol. 2001;8:789-94 pubmed publisher
Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their gene products...
Zhang R, Skarina T, Katz J, Beasley S, Khachatryan A, Vyas S, et al
. Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase. Structure. 2001;9:1095-106 pubmed
The rpoS, nlpD, pcm, and surE genes are among many whose expression is induced during the stationary phase of bacterial growth. rpoS codes for the stationary-phase RNA polymerase sigma subunit, and nlpD codes for a lipoprotein...
Iwasaki W, Miki K. Crystal structure of the stationary phase survival protein SurE with metal ion and AMP. J Mol Biol. 2007;371:123-36 pubmed publisher
The stationary phase survival protein SurE is a metal ion-dependent phosphatase distributed among eubacteria, archaea, and eukaryotes...
Visick J, Clarke S. RpoS- and OxyR-independent induction of HPI catalase at stationary phase in Escherichia coli and identification of rpoS mutations in common laboratory strains. J Bacteriol. 1997;179:4158-63 pubmed
..of HPII activity in strains carrying mutations in pcm (encoding the L-isoaspartyl protein methyltransferase) and surE led to the finding that these strains also have an amber mutation in rpoS; sequencing demonstrated the presence of ..
Li C, Wu P, Hsieh M. Growth-phase-dependent transcriptional regulation of the pcm and surE genes required for stationary-phase survival of Escherichia coli. Microbiology. 1997;143 ( Pt 11):3513-20 pubmed
Two neighbouring genes, surE and pcm, at 59 min on the Escherichia coli chromosome are both required for stationary-phase survival...
Riehle M, Bennett A, Long A. Genetic architecture of thermal adaptation in Escherichia coli. Proc Natl Acad Sci U S A. 2001;98:525-30 pubmed
..These results provide additional evidence for the idea that gene duplication plays an integral role in adaptation, specifically as a means for gene amplification. ..