Gene Symbol: trxC
Description: thioredoxin 2
Alias: ECK2580, JW2566, yfiG
Species: Escherichia coli str. K-12 substr. MG1655
Products:     trxC

Top Publications

  1. Waldman H. Baby fat is cute, but chubby kids may be in danger. ASDC J Dent Child. 2000;67:15-7, 8 pubmed
    ..An increasing percent of children are overweight. A review of the prevalence of overweight children in different demographic groups is provided in an effort to alert dentists to the role they could play in preventing medical complications. ..
  2. Toledano M, Kumar C, Le Moan N, Spector D, Tacnet F. The system biology of thiol redox system in Escherichia coli and yeast: differential functions in oxidative stress, iron metabolism and DNA synthesis. FEBS Lett. 2007;581:3598-607 pubmed
    ..We show that although prokaryotic and eukaryotic systems have a similar architecture, they profoundly differ in their overall cellular functions. ..
  3. Vlamis Gardikas A. The multiple functions of the thiol-based electron flow pathways of Escherichia coli: Eternal concepts revisited. Biochim Biophys Acta. 2008;1780:1170-200 pubmed publisher
    ..The emerging possibility is the development of novel antibiotics. ..
  4. Stewart E, Aslund F, Beckwith J. Disulfide bond formation in the Escherichia coli cytoplasm: an in vivo role reversal for the thioredoxins. EMBO J. 1998;17:5543-50 pubmed
    ..dependent on the presence of two thioredoxins in the cell, thioredoxins 1 and 2, the products of the genes trxA and trxC, respectively...
  5. Ritz D, Patel H, Doan B, Zheng M, Aslund F, Storz G, et al. Thioredoxin 2 is involved in the oxidative stress response in Escherichia coli. J Biol Chem. 2000;275:2505-12 pubmed
    ..On the other hand, transcriptional regulation is different. The expression of trxC is regulated by the transcriptional activator OxyR in response to oxidative stress...
  6. Cline D, Redding S, Brohawn S, Psathas J, Schneider J, Thorpe C. New water-soluble phosphines as reductants of peptide and protein disulfide bonds: reactivity and membrane permeability. Biochemistry. 2004;43:15195-203 pubmed
    ..In sum, these data suggest that there is considerable scope for the synthesis of phosphine analogues tailored for specific applications in biological systems...
  7. El Hajjaji H, Dumoulin M, Matagne A, Colau D, Roos G, Messens J, et al. The zinc center influences the redox and thermodynamic properties of Escherichia coli thioredoxin 2. J Mol Biol. 2009;386:60-71 pubmed publisher
    ..2 kJ/mol and 5.8 kJ/mol, respectively. In conclusion, our data show that the Zn(2+)-center of Trx2 fine-tunes the properties of this unique thioredoxin. ..
  8. Miranda Vizuete A, Damdimopoulos A, Gustafsson J, Spyrou G. Cloning, expression, and characterization of a novel Escherichia coli thioredoxin. J Biol Chem. 1997;272:30841-7 pubmed
    ..We here report the cloning of a gene (trxC) coding for a novel thioredoxin in Escherichia coli as well as the expression and characterization of its product...
  9. Potamitou A, Holmgren A, Vlamis Gardikas A. Protein levels of Escherichia coli thioredoxins and glutaredoxins and their relation to null mutants, growth phase, and function. J Biol Chem. 2002;277:18561-7 pubmed
    ..The levels of Grx2 and Grx3 behaved exactly the opposite, suggesting that the transcription factor OxyR does not regulate their expression. ..

More Information


  1. Collet J, D Souza J, Jakob U, Bardwell J. Thioredoxin 2, an oxidative stress-induced protein, contains a high affinity zinc binding site. J Biol Chem. 2003;278:45325-32 pubmed
    ..The zinc-free protein conserves its reductase activity. Altogether, our results suggest that the zinc center might play the role of a redox switch, changing a yet to be identified activity. ..
  2. Jacob C, Kriznik A, Boschi Muller S, Branlant G. Thioredoxin 2 from Escherichia coli is not involved in vivo in the recycling process of methionine sulfoxide reductase activities. FEBS Lett. 2011;585:1905-9 pubmed publisher
    ..The data demonstrate that the lack of growth of the metB(1)trxA mutant on Met-O is due to low in vivo expression of Trx2 and not to the lower catalytic efficiency of Msrs for Trx2. ..
  3. Ortenberg R, Gon S, Porat A, Beckwith J. Interactions of glutaredoxins, ribonucleotide reductase, and components of the DNA replication system of Escherichia coli. Proc Natl Acad Sci U S A. 2004;101:7439-44 pubmed
    ..Our results also suggest an unexpected regulatory interaction between the DnaA and DnaN proteins. ..
  4. Polianskiń≠ A, Kosinskiń≠ I, Efremov R. [The influence of local changes in the temperature-dependent conformational mobility of thioredoxins on their thermostability]. Bioorg Khim. 2004;30:470-80 pubmed
    ..The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // ..
  5. Pan J, Bardwell J. The origami of thioredoxin-like folds. Protein Sci. 2006;15:2217-27 pubmed
  6. Marulanda D, Tasayco M, McDermott A, Cataldi M, Arriaran V, Polenova T. Magic angle spinning solid-state NMR spectroscopy for structural studies of protein interfaces. resonance assignments of differentially enriched Escherichia coli thioredoxin reassembled by fragment complementation. J Am Chem Soc. 2004;126:16608-20 pubmed
  7. Meyer Y, Buchanan B, Vignols F, Reichheld J. Thioredoxins and glutaredoxins: unifying elements in redox biology. Annu Rev Genet. 2009;43:335-67 pubmed publisher
    ..The new information will be important not only to our understanding of the role of Trx and Grx in fundamental cell processes but also to future societal benefits as the proteins find new applications in a range of fields. ..