Gene Symbol: thiL
Description: thiamine monophosphate kinase
Alias: ECK0411, JW0407
Species: Escherichia coli str. K-12 substr. MG1655
Nakayama H, Hayashi R. Biosynthesis of thiamine pyrophosphate in Escherichia coli. J Bacteriol. 1972;109:936-8 pubmed
..In Escherichia coli, thiamine pyrophosphate is synthesized from thiamine monophosphate. Free thiamine is not involved as an intermediate in de novo synthesis of thiamine pyrophosphate. ..
Begley T, Downs D, Ealick S, McLafferty F, van Loon A, Taylor S, et al
. Thiamin biosynthesis in prokaryotes. Arch Microbiol. 1999;171:293-300 pubmed
..Of these, six are required for the thiazole biosynthesis (thiFSGH, thil, and dxs), one is involved in the pyrimidine biosynthesis (thiC), one is required for the linking of the thiazole ..
Torrents E, Grinberg I, Gorovitz Harris B, Lundström H, Borovok I, Aharonowitz Y, et al
. NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes. J Bacteriol. 2007;189:5012-21 pubmed
..The model assumes that differences in the positions of the NrdR binding sites, and in the sequences of the motifs themselves, determine the extent to which NrdR represses the transcription of each RNR operon. ..
Nishino H. Biogenesis of cocarboxylase in Escherichia coli. Partial purification and some properties of thiamine monophosphate kinase. J Biochem. 1972;72:1093-100 pubmed
Melnick J, Sprinz K, Reddick J, Kinsland C, Begley T. An efficient enzymatic synthesis of thiamin pyrophosphate. Bioorg Med Chem Lett. 2003;13:4139-41 pubmed
..This provides a facile route to isotopically labeled thiamin pyrophosphate from its readily available pyrimidine and thiazole precursors. ..
Veerareddygari G, Klusman T, Mueller E. Characterization of the catalytic disulfide bond in E. coli 4-thiouridine synthetase to elucidate its functional quaternary structure. Protein Sci. 2016;25:1737-43 pubmed publisher
Imamura N, Nakayama H. thiK and thiL loci of Escherichia coli. J Bacteriol. 1982;151:708-17 pubmed
..We found two genes, for which we propose the designations thiK and thiL, which govern the activities of thiamine kinase and thiamine monophosphate kinase, respectively...