Gene Symbol: talA
Description: transaldolase A
Alias: ECK2459, JW2448
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Follstad B, Stephanopoulos G. Effect of reversible reactions on isotope label redistribution--analysis of the pentose phosphate pathway. Eur J Biochem. 1998;252:360-71 pubmed
  2. Salmon K, Hung S, Steffen N, Krupp R, Baldi P, Hatfield G, et al. Global gene expression profiling in Escherichia coli K12: effects of oxygen availability and ArcA. J Biol Chem. 2005;280:15084-96 pubmed
    ..The strict statistical analyses that we have performed on our data allow us to predict that 1139 genes in the E. coli genome are regulated either directly or indirectly by the ArcA protein with a 99% confidence level. ..
  3. Rizk M, Liao J. Ensemble modeling for aromatic production in Escherichia coli. PLoS ONE. 2009;4:e6903 pubmed publisher
    ..This work demonstrates that EM is able to capture the result of enzyme overexpression on aromatic producing bacteria by successfully utilizing routinely generated enzyme tuning data to guide model learning. ..
  4. Samland A, Sprenger G. Transaldolase: from biochemistry to human disease. Int J Biochem Cell Biol. 2009;41:1482-94 pubmed publisher
    ..The involvement of TAL in oxidative stress and apoptosis, in multiple sclerosis, and in cancer is discussed. ..
  5. Weber A, Kögl S, Jung K. Time-dependent proteome alterations under osmotic stress during aerobic and anaerobic growth in Escherichia coli. J Bacteriol. 2006;188:7165-75 pubmed
    ..The protein profiles revealed an induction of 12 proteins (Dps, HchA, HdhA, InfB, OsmC, OsmY, ProX, KatE, PspA, TalA, TktB, and TreF) under osmotic stress in an aerobic milieu...
  6. Katz J, Rognstad R. The labeling of pentose phosphate from glucose-14C and estimation of the rates of transaldolase, transketolase, the contribution of the pentose cycle, and ribose phosphate synthesis. Biochemistry. 1967;6:2227-47 pubmed
  7. Lacour S, Landini P. SigmaS-dependent gene expression at the onset of stationary phase in Escherichia coli: function of sigmaS-dependent genes and identification of their promoter sequences. J Bacteriol. 2004;186:7186-95 pubmed
  8. Sprenger G. Genetics of pentose-phosphate pathway enzymes of Escherichia coli K-12. Arch Microbiol. 1995;164:324-30 pubmed
    ..In recent years, genes for all enzymes of the pathway have been cloned and sequenced. Isoenzymes have been found for transketolase (genes tktA and tktB), ribose-5-phosphate isomerase (rpiA and rpiB) and transaldolase (talA and talB).
  9. Avison M, Horton R, Walsh T, Bennett P. Escherichia coli CreBC is a global regulator of gene expression that responds to growth in minimal media. J Biol Chem. 2001;276:26955-61 pubmed
    ..the ackA/pta operon, the products of which collectively catalyze the conversion of acetyl-CoA into acetate and ATP; talA, which encodes an enzyme involved in the mobilization of glyceraldehyde-3-phosphate into the pentose phosphate ..

More Information


  1. Kleijn R, van Winden W, van Gulik W, Heijnen J. Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence. FEBS J. 2005;272:4970-82 pubmed
    ..Results show that the inclusion of isoenzymes affects the ensuing flux estimates. ..
  2. Iida A, Teshiba S, Mizobuchi K. Identification and characterization of the tktB gene encoding a second transketolase in Escherichia coli K-12. J Bacteriol. 1993;175:5375-83 pubmed
    ..Analysis of the phenotypes of the strains containing tktA, tktB, or tktA tktB mutations indicated that tktA and tktB were responsible for major and minor activities, respectively, of transketolase in E. coli. ..
  3. González García E, Helaine V, Klein G, Schuermann M, Sprenger G, Fessner W, et al. Fluorogenic stereochemical probes for transaldolases. Chemistry. 2003;9:893-9 pubmed
    ..The stereoselectivity of transaldolases can be readily measured by the relative rates of fluorescence development in the presence of the latter pair of diastereomeric substrates. ..
  4. Kang Y, Weber K, Qiu Y, Kiley P, Blattner F. Genome-wide expression analysis indicates that FNR of Escherichia coli K-12 regulates a large number of genes of unknown function. J Bacteriol. 2005;187:1135-60 pubmed publisher
    ..We suggest that E. coli MG1655 has a larger metabolic potential under anaerobic conditions than has been previously recognized...
  5. Weber H, Polen T, Heuveling J, Wendisch V, Hengge R. Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity. J Bacteriol. 2005;187:1591-603 pubmed
    ..Thus, not only the expression of genes within a regulatory network but also the architecture of the network itself can be subject to regulation. ..
  6. Song B, Kim T, Jung Y, Lee Y. Modulation of talA gene in pentose phosphate pathway for overproduction of poly-beta-hydroxybutyrate in transformant Escherichia coli harboring phbCAB operon. J Biosci Bioeng. 2006;102:237-40 pubmed
    The talA gene encoding transaldolase, the key enzyme in the nonoxidative pentose phosphate pathway, was amplified in a transformant Escherichia coli harboring the phbCAB operon to shift the metabolic flux of the hexose mono-phosphate ..
  7. Rahman M, Shimizu K. Altered acetate metabolism and biomass production in several Escherichia coli mutants lacking rpoS-dependent metabolic pathway genes. Mol Biosyst. 2008;4:160-9 pubmed publisher
    ..In the present study, batch cultivations were performed using tktB, talA, fumC or acnA-knockout mutants of Escherichia coli to observe the metabolic changes at different phases of growth ..
  8. Harinarayanan R, Murphy H, Cashel M. Synthetic growth phenotypes of Escherichia coli lacking ppGpp and transketolase A (tktA) are due to ppGpp-mediated transcriptional regulation of tktB. Mol Microbiol. 2008;69:882-94 pubmed publisher
    ..using PtalA-tktB'-lacZ transcriptional reporter fusion, we show positive transcriptional regulation of the talA-tktB operon by ppGpp...