Gene Symbol: tadA
Description: tRNA-specific adenosine deaminase
Alias: ECK2557, JW2543, yfhC
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Poulsen L, Larsen N, Molin S, Andersson P. Analysis of an Escherichia coli mutant strain resistant to the cell-killing function encoded by the gef gene family. Mol Microbiol. 1992;6:895-905 pubmed
    ..1 kDa. ORF178 and an upstream frame, ORF190, probably constitute an operon...
  2. Elias Y, Huang R. Biochemical and structural studies of A-to-I editing by tRNA:A34 deaminases at the wobble position of transfer RNA. Biochemistry. 2005;44:12057-65 pubmed
    ..The enzymes responsible for this A-to-I conversion in tRNA are tadA (acting as a homodimer) in prokaryotes and the heterodimeric ADAT2-ADAT3 complex in eukaryotes...
  3. Kim J, Malashkevich V, Roday S, Lisbin M, Schramm V, Almo S. Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. Biochemistry. 2006;45:6407-16 pubmed
    ..This work begins to define the chemical and structural determinants responsible for catalysis and substrate recognition and lays the foundation for detailed mechanistic analysis of this essential enzyme. ..
  4. Luo M, Schramm V. Transition state structure of E. coli tRNA-specific adenosine deaminase. J Am Chem Soc. 2008;130:2649-55 pubmed publisher
    Bacterial tRNA-specific adenosine deaminase (TadA) catalyzes the essential deamination of adenosine to inosine at the wobble position of tRNAs and is necessary to permit a single tRNA species to recognize multiple codons...
  5. Wolf J, Gerber A, Keller W. tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. EMBO J. 2002;21:3841-51 pubmed
    We report the characterization of tadA, the first prokaryotic RNA editing enzyme to be identified. Escherichia coli tadA displays sequence similarity to the yeast tRNA deaminase subunit Tad2p...