Gene Symbol: sslE
Description: putative secreted and surface-associated lipoprotein mucinase
Alias: ECK2968, JW5925, acfD, yghJ
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Luo Q, Kumar P, Vickers T, Sheikh A, Lewis W, Rasko D, et al. Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells. Infect Immun. 2014;82:509-21 pubmed publisher
    ..Many elements of ETEC pathogenesis are still poorly defined. Here we demonstrate that YghJ, a secreted ETEC antigen identified in immunoproteomic studies using convalescent patient sera, is required for ..
  2. Nesta B, Valeri M, Spagnuolo A, Rosini R, Mora M, Donato P, et al. SslE elicits functional antibodies that impair in vitro mucinase activity and in vivo colonization by both intestinal and extraintestinal Escherichia coli strains. PLoS Pathog. 2014;10:e1004124 pubmed publisher
    b>SslE, the Secreted and surface-associated lipoprotein from Escherichia coli, has recently been associated to the M60-like extracellular zinc-metalloprotease sub-family which is implicated in glycan recognition and processing...
  3. Valeri M, Rossi Paccani S, Kasendra M, Nesta B, Serino L, Pizza M, et al. Pathogenic E. coli exploits SslE mucinase activity to translocate through the mucosal barrier and get access to host cells. PLoS ONE. 2015;10:e0117486 pubmed publisher
    b>SslE is a zinc-metalloprotease involved in the degradation of mucin substrates and recently proposed as a potential vaccine candidate against pathogenic E. coli...
  4. Tan L, Moriel D, Totsika M, Beatson S, Schembri M. Differential Regulation of the Surface-Exposed and Secreted SslE Lipoprotein in Extraintestinal Pathogenic Escherichia coli. PLoS ONE. 2016;11:e0162391 pubmed publisher
    ..b>SslE is a lipoprotein secreted by a dedicated type II secretion system in E...
  5. Tapader R, Bose D, Pal A. YghJ, the secreted metalloprotease of pathogenic E. coli induces hemorrhagic fluid accumulation in mouse ileal loop. Microb Pathog. 2017;105:96-99 pubmed publisher
    b>YghJ, also known as SslE (Secreted and surface associated lipoprotein) is a cell surface associated and secreted lipoprotein harbouring M60 metalloprotease domain...
  6. Twiss E, Coros A, Tavakoli N, Derbyshire K. Transposition is modulated by a diverse set of host factors in Escherichia coli and is stimulated by nutritional stress. Mol Microbiol. 2005;57:1593-607 pubmed
    ..In summary, this work identifies a collection of proteins that allow the host to modulate transposition in response to cell stress. ..