Gene Symbol: srkA
Description: Cpx stress response Thr/Ser protein kinase; MazF antagonist protein
Alias: ECK3851, JW3831, orfA, rdoA, yihE
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Li M, Kroll J, Yu J. Influence of the yihE gene of Shigella flexneri on global gene expression: on analysis using DNA arrays. Biochem Biophys Res Commun. 2001;288:91-100 pubmed
    ..However, Sh4 and Sh42 behave differently in many ways in vitro and in vivo. A gene of unknown function, yihE, up-stream and cotranscribed with dsbA, is thought to differentiate Sh4 and Sh42 as the kan insertion may result in ..
  2. Suntharalingam P, Spencer H, Gallant C, Martin N. Salmonella enterica serovar typhimurium rdoA is growth phase regulated and involved in relaying Cpx-induced signals. J Bacteriol. 2003;185:432-43 pubmed
    ..coli demonstrated that dsbA is part of a two-gene operon that includes an uncharacterized, upstream gene, yihE, that is positively regulated via the Cpx stress response pathway...
  3. Edwards Jones B, Langford P, Kroll J, Yu J. The role of the Shigella flexneri yihE gene in LPS synthesis and virulence. Microbiology. 2004;150:1079-84 pubmed
    Previously, the authors have shown that inactivation of Shigella flexneri yihE, a gene of unknown function upstream of dsbA, which encodes a periplasmic disulphide catalyst, results in a global change of gene expression...
  4. Belin P, Boquet P. The Escherichia coli dsbA gene is partly transcribed from the promoter of a weakly expressed upstream gene. Microbiology. 1994;140 ( Pt 12):3337-48 pubmed
    ..Analysis of its surrounding DNA region showed that it is preceded by an open reading frame, orfA, of 984 nucleotides. The intergenic region (19 nucleotides) carries no typical transcription termination signals...
  5. Zheng J, He C, Singh V, Martin N, Jia Z. Crystal structure of a novel prokaryotic Ser/Thr kinase and its implication in the Cpx stress response pathway. Mol Microbiol. 2007;63:1360-71 pubmed
    ..Functional assays established that both YihE and the S. enterica YihE homologue, RdoA, undergo autophosphorylation and phosphorylate protein substrates at Ser/Thr residues in vitro, demonstrating that ..
  6. Pogliano J, Lynch A, Belin D, Lin E, Beckwith J. Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system. Genes Dev. 1997;11:1169-82 pubmed
    ..coli genes. These findings suggest a potentially extensive Cpx regulon including genes transcribed by sigma70 and sigma(E), which encode factors involved in protein folding as well as other cellular functions. ..