Gene Symbol: slmA
Description: nucleoid occlusion factor, anti-FtsZ division inhibitor
Alias: ECK3631, JW5641, ttk, yicB
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Wu L, Errington J. Coordination of cell division and chromosome segregation by a nucleoid occlusion protein in Bacillus subtilis. Cell. 2004;117:915-25 pubmed
    ..The results help to explain how B. subtilis specifies the division site under a range of conditions and how it avoids catastrophic breakage of the chromosome by division through the nucleoid. ..
  2. Bernhardt T, de Boer P. SlmA, a nucleoid-associated, FtsZ binding protein required for blocking septal ring assembly over Chromosomes in E. coli. Mol Cell. 2005;18:555-64 pubmed
    ..By using this approach, we identified SlmA (Ttk) as the first NO factor in E. coli...
  3. Ramos J, Martínez Bueno M, Molina Henares A, Teran W, Watanabe K, Zhang X, et al. The TetR family of transcriptional repressors. Microbiol Mol Biol Rev. 2005;69:326-56 pubmed
    ..Information related to the TetR family of regulators has been updated in a database that can be accessed at ..
  4. Tonthat N, Arold S, Pickering B, Van Dyke M, Liang S, Lu Y, et al. Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check. EMBO J. 2011;30:154-64 pubmed publisher
    ..Here, we describe studies addressing the molecular mechanism of SlmA (synthetic lethal with a defective Min system)-mediated NO...
  5. Cho H, McManus H, Dove S, Bernhardt T. Nucleoid occlusion factor SlmA is a DNA-activated FtsZ polymerization antagonist. Proc Natl Acad Sci U S A. 2011;108:3773-8 pubmed publisher
    ..cell division with chromosome segregation, Escherichia coli employs the nucleoid-associated division inhibitor, SlmA. Here, we investigate the mechanism by which SlmA regulates FtsZ assembly...
  6. Cho H, Bernhardt T. Identification of the SlmA active site responsible for blocking bacterial cytokinetic ring assembly over the chromosome. PLoS Genet. 2013;9:e1003304 pubmed publisher
    ..b>SlmA from Escherichia coli, a member of the tetracycline repressor (TetR)-like protein family, is one example of this ..
  7. Tonthat N, Milam S, Chinnam N, Whitfill T, Margolin W, Schumacher M. SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid. Proc Natl Acad Sci U S A. 2013;110:10586-91 pubmed publisher
    ..In Escherichia coli, the synthetic lethal with a defective Min system (SlmA) protein helps mediate nucleoid occlusion, which prevents chromosome fragmentation by binding FtsZ and inhibiting Z-..
  8. el Hajj H, Wang L, Weiss B. Multiple mutant of Escherichia coli synthesizing virtually thymineless DNA during limited growth. J Bacteriol. 1992;174:4450-6 pubmed
    ..7- to 2.7-fold, suggesting a general failure of macromolecular biosynthesis. DNA hybridization confirmed that the uracil-containing DNA was chromosomal and that new rounds of initiation must have occurred during its synthesis. ..
  9. el Hajj H, Zhang H, Weiss B. Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli. J Bacteriol. 1988;170:1069-75 pubmed
    ..mutation could not be explained by effects on adjacent genes; the dfp gene retained complementing activity, and a ttk insertion mutant was viable...

More Information


  1. Spitzer E, Weiss B. dfp Gene of Escherichia coli K-12, a locus affecting DNA synthesis, codes for a flavoprotein. J Bacteriol. 1985;164:994-1003 pubmed
    ..The ability of a plasmid to complement a chromosomal dfp-707 mutation was correlated with its ability to produce a 45-kilodalton polypeptide. The purified protein contained 1 mol of flavin mononucleotide per mol of polypeptide. ..
  2. Lundberg L, Thoresson H, Karlström O, Nyman P. Nucleotide sequence of the structural gene for dUTPase of Escherichia coli K-12. EMBO J. 1983;2:967-71 pubmed
    ..wt. 23 500 to this DNA region. The open reading frame thus may correspond to a protein of unknown function co-transcribed with the dut gene. ..
  3. Du S, Lutkenhaus J. SlmA antagonism of FtsZ assembly employs a two-pronged mechanism like MinCD. PLoS Genet. 2014;10:e1004460 pubmed publisher prevented by a process called nucleoid occlusion (NO), which in Escherichia coli is partially mediated by SlmA. SlmA is a Z ring antagonist that is spatially regulated and activated by binding to specific DNA sequences (SlmA ..
  4. Bailey M, Bisicchia P, Warren B, Sherratt D, Männik J. Evidence for divisome localization mechanisms independent of the Min system and SlmA in Escherichia coli. PLoS Genet. 2014;10:e1004504 pubmed publisher
    ..In E. coli, nucleoid occlusion is mediated by the SlmA proteins...
  5. Schumacher M, Zeng W. Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. Proc Natl Acad Sci U S A. 2016;113:4988-93 pubmed publisher
    ..The DNA-binding protein SlmA binds to FtsZ and prevents Z-ring formation through the nucleoid in a process called "nucleoid occlusion" (NO)...