Gene Symbol: sdiA
Description: quorum-sensing transcriptional activator
Alias: ECK1915, JW1901, uvrX
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Rychlik I, Barrow P. Salmonella stress management and its relevance to behaviour during intestinal colonisation and infection. FEMS Microbiol Rev. 2005;29:1021-40 pubmed
    ..The role of quorum-sensing through luxS and sdiA is also considered as a regulator of virulence and colonisation.
  2. Yao Y, Martinez Yamout M, Dickerson T, Brogan A, Wright P, Dyson H. Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones. J Mol Biol. 2006;355:262-73 pubmed
    The three-dimensional structure of a complex between the N-terminal domain of the quorum sensing protein SdiA of Escherichia coli and a candidate autoinducer N-octanoyl-L-homoserine lactone (C8-HSL) has been calculated in solution from ..
  3. Van Houdt R, Aertsen A, Moons P, Vanoirbeek K, Michiels C. N-acyl-L-homoserine lactone signal interception by Escherichia coli. FEMS Microbiol Lett. 2006;256:83-9 pubmed
    ..because it lacks an AHL synthase encoding gene, it does produce a predicted AHL receptor of the LuxR family, named SdiA. In this work, we used a promoter trap library to screen for E...
  4. Garcia Lara J, Shang L, Rothfield L. An extracellular factor regulates expression of sdiA, a transcriptional activator of cell division genes in Escherichia coli. J Bacteriol. 1996;178:2742-8 pubmed
    The sdiA gene codes for a protein that regulates expression of the ftsQAZ cluster of essential cell division genes of Escherichia coli. SdiA up-regulates the ftsQ2p promoter that initiates transcription into the ftsQAZ cluster...
  5. Walters M, Sperandio V. Quorum sensing in Escherichia coli and Salmonella. Int J Med Microbiol. 2006;296:125-31 pubmed
    ..quorum-sensing systems, such as: the luxS/AI-2, AI-3/epinephrine/norepinephrine, indole, and the LuxR homolog SdiA to achieve intercellular signaling...
  6. Kanamaru K, Tatsuno I, Tobe T, Sasakawa C. SdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol. 2000;38:805-16 pubmed
    ..In this study, we found that SdiA, an Escherichia coli LuxR homologue, is a negative regulator of the expression of virulence factors EspD and ..
  7. Wei Y, Lee J, Smulski D, LaRossa R. Global impact of sdiA amplification revealed by comprehensive gene expression profiling of Escherichia coli. J Bacteriol. 2001;183:2265-72 pubmed
    In Escherichia coli the amplification of sdiA, a positive activator of ftsQAZ, genes that are essential for septation, results in mitomycin C resistance...
  8. Sitnikov D, Schineller J, Baldwin T. Control of cell division in Escherichia coli: regulation of transcription of ftsQA involves both rpoS and SdiA-mediated autoinduction. Proc Natl Acad Sci U S A. 1996;93:336-41 pubmed
    ..rpoS-stimulated and the second, P2, is regulated by a member of the LuxR subfamily of transcriptional activators, SdiA, exhibiting features characteristic of an autoinduction (quorum sensing) mechanism...
  9. Michael B, Smith J, Swift S, Heffron F, Ahmer B. SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities. J Bacteriol. 2001;183:5733-42 pubmed
    ..The sdiA genes of Escherichia coli and Salmonella enterica serovar Typhimurium are predicted to encode LuxR homologs...

More Information


  1. Lindsay A, Ahmer B. Effect of sdiA on biosensors of N-acylhomoserine lactones. J Bacteriol. 2005;187:5054-8 pubmed publisher
    ..However, both Escherichia and Salmonella spp. contain a LuxR homolog named SdiA that can detect exogenous AHL synthesized by other microbial species...
  2. Rahmati S, Yang S, Davidson A, Zechiedrich E. Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA. Mol Microbiol. 2002;43:677-85 pubmed
    b>SdiA is an Escherichia coli protein that regulates cell division in a cell density-dependent, or quorum-sensing, manner. We report that SdiA also controls multidrug resistance by positively regulating the multidrug resistance pump AcrAB...
  3. Hao Y, Updegrove T, Livingston N, Storz G. Protection against deleterious nitrogen compounds: role of ?S-dependent small RNAs encoded adjacent to sdiA. Nucleic Acids Res. 2016;44:6935-48 pubmed publisher
    ..sRNAs) expressed from an Escherichia coli locus we have denoted sdsN located adjacent to the LuxR-homolog gene sdiA Two longer sRNAs, SdsN137 and SdsN178 are transcribed from two ?(S)-dependent promoters but share the same ..
  4. Delisa M, Valdes J, Bentley W. Mapping stress-induced changes in autoinducer AI-2 production in chemostat-cultivated Escherichia coli K-12. J Bacteriol. 2001;183:2918-28 pubmed
    ..Significant regulatory overlap was revealed among several stress and starvation genes and known quorum-sensing genes. ..
  5. Yamamoto K, Yata K, Fujita N, Ishihama A. Novel mode of transcription regulation by SdiA, an Escherichia coli homologue of the quorum-sensing regulator. Mol Microbiol. 2001;41:1187-98 pubmed
    b>SdiA, an Escherichia coli homologue of the quorum-sensing regulator, controls the expression of the ftsQAZ operon for cell division...
  6. Fang X, Bentley W, Zafiriou E. Stochastic modeling of gene positive autoregulation networks involving signal molecules. Biophys J. 2008;95:3137-45 pubmed publisher
    ..We use the regulation of SdiA in Escherichia coli as an example, due to the importance of this protein and of the signal molecule, a bacterial ..
  7. Sabag Daigle A, Soares J, Smith J, Elmasry M, Ahmer B. The acyl homoserine lactone receptor, SdiA, of Escherichia coli and Salmonella enterica serovar Typhimurium does not respond to indole. Appl Environ Microbiol. 2012;78:5424-31 pubmed publisher
    In this study, we tested the hypothesis that the SdiA proteins of Escherichia coli and Salmonella enterica serovar Typhimurium respond to indole...
  8. Ahmer B. Cell-to-cell signalling in Escherichia coli and Salmonella enterica. Mol Microbiol. 2004;52:933-45 pubmed
    ..Both organisms encode a signal receptor of the LuxR family, SdiA, but not a corresponding signal-generating enzyme...
  9. Lee J, Maeda T, Hong S, Wood T. Reconfiguring the quorum-sensing regulator SdiA of Escherichia coli to control biofilm formation via indole and N-acylhomoserine lactones. Appl Environ Microbiol. 2009;75:1703-16 pubmed publisher
    b>SdiA is a homolog of quorum-sensing regulators that detects N-acylhomoserine lactone (AHL) signals from other bacteria. Escherichia coli uses SdiA to reduce its biofilm formation in the presence of both AHLs and its own signal indole...
  10. Wei Y, Vollmer A, LaRossa R. In vivo titration of mitomycin C action by four Escherichia coli genomic regions on multicopy plasmids. J Bacteriol. 2001;183:2259-64 pubmed
    ..MMC resistance is caused by the presence of any of four distinct E. coli genes (mdfA, gyrl, rob, and sdiA) on high-copy-number vectors...
  11. Lee J, Jayaraman A, Wood T. Indole is an inter-species biofilm signal mediated by SdiA. BMC Microbiol. 2007;7:42 pubmed
    ..coli biofilms by repressing motility, inducing the sensor of the quorum sensing signal autoinducer-1 (SdiA), and influencing acid resistance (e.g., hdeABD, gadABCEX)...
  12. Wu C, Lokanath N, Kim D, Nguyen L, Kim K. Crystallization and preliminary X-ray studies of SdiA from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:19-21 pubmed
    b>SdiA enhances cell division by regulating the ftsQAZ operon in Escherichia coli as a transcription activator. In addition, SdiA is suggested to play a role in detecting quorum signals that emanate from other species...
  13. Zhou X, Meng X, Sun B. An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems in Escherichia coli. Cell Res. 2008;18:937-48 pubmed publisher
    ..stimulated by the cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex and a partial QS system 1 that consists of SdiA (suppressor of cell division inhibitor) responding to signals generated by other microbial species...
  14. Smith J, Fratamico P, Yan X. Eavesdropping by bacteria: the role of SdiA in Escherichia coli and Salmonella enterica serovar Typhimurium quorum sensing. Foodborne Pathog Dis. 2011;8:169-78 pubmed publisher
    ..Escherichia coli and Salmonella enterica do not synthesize AHLs but do contain the AHL receptor, SdiA. Studies reveal that SdiA can bind AHLs produced by other bacterial species and thereby allow E. coli and S...
  15. Wang X, de Boer P, Rothfield L. A factor that positively regulates cell division by activating transcription of the major cluster of essential cell division genes of Escherichia coli. EMBO J. 1991;10:3363-72 pubmed
    ..The trans-acting factor is the product of the sdiA gene, which was isolated on the basis of its ability to suppress the division inhibitory effect of the MinC/MinD ..
  16. Suzuki K, Wang X, Weilbacher T, Pernestig A, Melefors O, Georgellis D, et al. Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli. J Bacteriol. 2002;184:5130-40 pubmed
    ..Disruption of sdiA, which encodes a LuxR homologue, decreased the expression of uvrY'-'lacZ and csrB-lacZ fusions but did not affect ..
  17. Donachie W. Co-ordinate regulation of the Escherichia coli cell cycle or The cloud of unknowing. Mol Microbiol. 2001;40:779-85 pubmed
    ..A discussion of some aspects of the regulation of chromosome replication, segregation and cell division in Escherichia coli. ..
  18. Yao Y, Dickerson T, Hixon M, Dyson H. NMR detection of adventitious xylose binding to the quorum-sensing protein SdiA of Escherichia coli. Bioorg Med Chem Lett. 2007;17:6202-5 pubmed
    During the solution structure determination of the Escherichia coli quorum-sensing protein SdiA in the presence of N-octanoyl-l-homoserine lactone (HSL), NMR signals were detected in (13)C-filter-(13)C-filter spectra for the bound HSL ..
  19. Lee J, Zhang X, Hegde M, Bentley W, Jayaraman A, Wood T. Indole cell signaling occurs primarily at low temperatures in Escherichia coli. ISME J. 2008;2:1007-23 pubmed publisher 25 and 30 degrees C than at 37 degrees C and that the effect is associated with the quorum-sensing protein SdiA. The addition of indole at 30 degrees C compared to 37 degrees C most significantly repressed genes involved in ..
  20. Yao Y, Martinez Yamout M, Dyson H. Backbone and side chain 1H, 13C and 15N assignments for Escherichia coli SdiA1-171, the autoinducer-binding domain of a quorum sensing protein. J Biomol NMR. 2005;31:373-4 pubmed
  21. Yakhnin H, Baker C, Berezin I, Evangelista M, Rassin A, Romeo T, et al. CsrA represses translation of sdiA, which encodes the N-acylhomoserine-L-lactone receptor of Escherichia coli, by binding exclusively within the coding region of sdiA mRNA. J Bacteriol. 2011;193:6162-70 pubmed publisher
    ..b>sdiA encodes the quorum-sensing receptor for N-acyl-l-homoserine lactone in Escherichia coli...
  22. Shimada T, Shimada K, Matsui M, Kitai Y, Igarashi J, Suga H, et al. Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets. Genes Cells. 2014;19:405-18 pubmed publisher
    ..Transcription factor SdiA for cell division control is believed to play a role as a HSL sensor...
  23. Ghosh D, Roy K, Williamson K, Srinivasiah S, Wommack K, Radosevich M. Acyl-homoserine lactones can induce virus production in lysogenic bacteria: an alternative paradigm for prophage induction. Appl Environ Microbiol. 2009;75:7142-52 pubmed publisher
    ..In the same lambda lysogen we also demonstrated that sdiA, the AHL receptor, and rcsA, a positive transcriptional regulator of exopolysaccharide synthesis, are involved in ..
  24. Ahmer B, van Reeuwijk J, Timmers C, Valentine P, Heffron F. Salmonella typhimurium encodes an SdiA homolog, a putative quorum sensor of the LuxR family, that regulates genes on the virulence plasmid. J Bacteriol. 1998;180:1185-93 pubmed
    ..The gene encoding one LuxR family member, named sdiA (suppressor of cell division inhibition), is present in the Escherichia coli genome...
  25. Kim T, Duong T, Wu C, Choi J, Lan N, Kang S, et al. Structural insights into the molecular mechanism of Escherichia coli SdiA, a quorum-sensing receptor. Acta Crystallogr D Biol Crystallogr. 2014;70:694-707 pubmed publisher
    Escherichia coli SdiA is a quorum-sensing (QS) receptor that responds to autoinducers produced by other bacterial species to control cell division and virulence. Crystal structures reveal that E...
  26. Sharma S, Stark T, Beattie W, Moses R. Multiple control elements for the uvrC gene unit of Escherichia coli. Nucleic Acids Res. 1986;14:2301-18 pubmed
    ..The upstream region including the 28 kd protein is required for enhanced expression under non-induced conditions. These results show that the uvrC gene is controlled by multiple promoters and is transcribed as part of a multigene unit. ..