Gene Symbol: sbmA
Description: peptide antibiotic transporter
Alias: ECK0372, JW0368
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. LeVier K, Walker G. Genetic analysis of the Sinorhizobium meliloti BacA protein: differential effects of mutations on phenotypes. J Bacteriol. 2001;183:6444-53 pubmed
    ..The remaining 12 site-directed mutants demonstrate mixed phenotypic characteristics and fall into a number of distinctly different groups. These observations may be consistent with a role for BacA in multiple, nonoverlapping functions. ..
  2. Salomon R, Farias R. The peptide antibiotic microcin 25 is imported through the TonB pathway and the SbmA protein. J Bacteriol. 1995;177:3323-5 pubmed
    ..Phenotypic and mapping studies showed the mutations to be located in the fhuA, exb, tonB, and sbmA genes. The latter encodes a cytoplasmic membrane protein which is also required for the penetration of microcin B17. ..
  3. Corbalán N, Adler C, de Cristóbal R, Pomares M, Delgado M, Vincent P. The tolC locus affects the expression of sbmA through ?E activity increase. FEMS Microbiol Lett. 2010;311:185-92 pubmed publisher
    The SbmA protein is involved in the transport of MccB17-, MccJ25-, bleomycin- and proline-rich peptides into the Escherichia coli cytoplasm. sbmA gene homologues were found in a variety of bacteria...
  4. Yorgey P, Lee J, Kördel J, Vivas E, Warner P, Jebaratnam D, et al. Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor. Proc Natl Acad Sci U S A. 1994;91:4519-23 pubmed
    ..Escherichia coli sbmA mutants, which lack the inner membrane protein (SbmA) involved in MccB17 uptake, were found to be resistant to ..
  5. de Cristóbal R, Vincent P, Salomon R. A combination of sbmA and tolC mutations in Escherichia coli K-12 Tn10-carrying strains results in hypersusceptibility to tetracycline. J Bacteriol. 2008;190:1491-4 pubmed
    ..In this study, we found that the addition of an sbmA mutation to a tolC::Tn10 mutant exacerbates this phenotype: the double mutant did not form colonies, even in the ..
  6. Mattiuzzo M, Bandiera A, Gennaro R, Benincasa M, Pacor S, Antcheva N, et al. Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides. Mol Microbiol. 2007;66:151-63 pubmed
    ..We isolated a number of genomic regions bearing such genes, and one in particular coding for SbmA, an inner membrane protein predicted to be part of an ABC transporter. An E...
  7. Socias S, Severinov K, Salomon R. The Ile13 residue of microcin J25 is essential for recognition by the receptor FhuA, but not by the inner membrane transporter SbmA. FEMS Microbiol Lett. 2009;301:124-9 pubmed publisher
    ..J25 (MccJ25) into target cells is mediated by the outer membrane receptor FhuA and the inner membrane protein SbmA. The latter also transports MccB17 into the cell cytoplasm...
  8. Lavina M, Pugsley A, Moreno F. Identification, mapping, cloning and characterization of a gene (sbmA) required for microcin B17 action on Escherichia coli K12. J Gen Microbiol. 1986;132:1685-93 pubmed
    ..The mutations in these strains were mapped to a gene (sbmA), located at 8.7 min on the E. coli K12 chromosome, which is closely linked to phoA...
  9. de Cristóbal R, Solbiati J, Zenoff A, Vincent P, Salomon R, Yuzenkova J, et al. Microcin J25 uptake: His5 of the MccJ25 lariat ring is involved in interaction with the inner membrane MccJ25 transporter protein SbmA. J Bacteriol. 2006;188:3324-8 pubmed
    ..MccJ25 enters cells after binding to specific membrane transporters: FhuA in the outer membrane and SbmA in the inner membrane. Here, we studied MccJ25 mutants carrying a substitution of His5 by Lys, Arg, or Ala...

More Information


  1. Runti G, López Ruiz M, Stoilova T, Hussain R, Jennions M, Choudhury H, et al. Functional characterization of SbmA, a bacterial inner membrane transporter required for importing the antimicrobial peptide Bac7(1-35). J Bacteriol. 2013;195:5343-51 pubmed publisher
    b>SbmA is an inner membrane protein of Gram-negative bacteria that is involved in the internalization of glycopeptides and prokaryotic and eukaryotic antimicrobial peptides, as well as of peptide nucleic acid (PNA) oligomers...
  2. Krizsan A, Knappe D, Hoffmann R. Influence of the yjiL-mdtM Gene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System. Antimicrob Agents Chemother. 2015;59:5992-8 pubmed publisher
    ..These sbmA::Tn10 insertion mutants and the Escherichia coli BW25113 ΔsbmA (JW0368) strain were still susceptible to the bactenecin PrAMP Bac7(1-35) and oncocin PrAMPs Onc18 and Onc112, as well as ..
  3. Rezuchova B, Miticka H, Homerova D, Roberts M, Kormanec J. New members of the Escherichia coli sigmaE regulon identified by a two-plasmid system. FEMS Microbiol Lett. 2003;225:1-7 pubmed
    ..tufA, recR), phospholipid and lipopolysaccharide biosynthesis (psd, lpxP), signal transduction (sixA), proposed inner or outer membrane proteins (bacA, sbmA, smpA, yeaY), and proteins with unknown function (ybaB, yaiW, yiiS, yiiT, yfeY).