Gene Symbol: rseB
Description: periplasmic negative regulator of sigmaE
Species: Escherichia coli O157:H7 str. Sakai

Top Publications

  1. Ahnn J, March P, Takiff H, Inouye M. A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins. Proc Natl Acad Sci U S A. 1986;83:8849-53 pubmed
    ..These data indicate that ras-related sequences occur not only in eukaryotes but also in prokaryotes. ..
  2. De Las Penas A, Connolly L, Gross C. The sigmaE-mediated response to extracytoplasmic stress in Escherichia coli is transduced by RseA and RseB, two negative regulators of sigmaE. Mol Microbiol. 1997;24:373-85 pubmed
    ..Deletion of rseB leads to a slight induction of sigma(E), indicating that RseB is also a negative regulator of sigma(E)...
  3. Flachmann R, Kunz N, Seifert J, G tlich M, Wientjes F, L ufer A, et al. Molecular biology of pyridine nucleotide biosynthesis in Escherichia coli. Cloning and characterization of quinolinate synthesis genes nadA and nadB. Eur J Biochem. 1988;175:221-8 pubmed
    ..High-copy-number vectors, carrying either gene nadA, nadB or nadA + nadB, increased quinolinate production 1.5-fold, 2.0-fold and 15-fold respectively. Both gene products seem to be equally rate-limiting in quinolinate synthesis...
  4. March P, Inouye M. Characterization of the lep operon of Escherichia coli. Identification of the promoter and the gene upstream of the signal peptidase I gene. J Biol Chem. 1985;260:7206-13 pubmed
    ..The DNA sequence immediately downstream of the lep gene contains features consistent with a rho factor-independent transcriptional termination site, indicating that the lep operon encodes only two proteins (lepA and lep). ..
  5. Poulsen L, Larsen N, Molin S, Andersson P. Analysis of an Escherichia coli mutant strain resistant to the cell-killing function encoded by the gef gene family. Mol Microbiol. 1992;6:895-905 pubmed
    ..1 kDa. ORF178 and an upstream frame, ORF190, probably constitute an operon...
  6. Varshney U, Hutcheon T, van de Sande J. Sequence analysis, expression, and conservation of Escherichia coli uracil DNA glycosylase and its gene (ung). J Biol Chem. 1988;263:7776-84 pubmed
    ..No sequence homologies were seen for Pseudomonas, Clostridium, Micrococcus, and several eukaryotic genomes. ..
  7. Missiakas D, Mayer M, Lemaire M, Georgopoulos C, Raina S. Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins. Mol Microbiol. 1997;24:355-71 pubmed
    ..The sigma(E) activity is further modulated by the products of the remaining genes in this operon, rseB and rseC...
  8. Nitta T, Nagamitsu H, Murata M, Izu H, Yamada M. Function of the sigma(E) regulon in dead-cell lysis in stationary-phase Escherichia coli. J Bacteriol. 2000;182:5231-7 pubmed
    ..We propose there is a novel physiological function of the sigma(E) regulon that may guarantee cell survival in prolonged stationary phase by providing nutrients from dead cells for the next generation. ..
  9. Hiratsu K, Amemura M, Nashimoto H, Shinagawa H, Makino K. The rpoE gene of Escherichia coli, which encodes sigma E, is essential for bacterial growth at high temperature. J Bacteriol. 1995;177:2918-22 pubmed
    ..We demonstrate that expression of htrA is completely dependent on the rpoE gene in vivo and that the rpoE gene is essential for bacterial growth at high temperature. ..

More Information


  1. Yu H, Schurr M, Deretic V. Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa. J Bacteriol. 1995;177:3259-68 pubmed
    ..aeruginosa and suggest that elements showing sequence similarity to those known to regulate AlgU activity in P. aeruginosa are also present in other bacteria...
  2. Nashimoto H, Uchida H. DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations. Mol Gen Genet. 1985;201:25-9 pubmed
    ..coli. ..
  3. Collinet B, Yuzawa H, Chen T, Herrera C, Missiakas D. RseB binding to the periplasmic domain of RseA modulates the RseA:sigmaE interaction in the cytoplasm and the availability of sigmaE.RNA polymerase. J Biol Chem. 2000;275:33898-904 pubmed
    ..The C-terminal domain of RseA interacts with RseB, a periplasmic protein...
  4. Alba B, Leeds J, Onufryk C, Lu C, Gross C. DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response. Genes Dev. 2002;16:2156-68 pubmed publisher
    ..Thus, mammalian and bacterial cells employ a conserved proteolytic mechanism to activate membrane-associated transcription factors that initiate intercompartmental cellular stress responses...
  5. Morrison P, Lovett S, Gilson L, Kolodner R. Molecular analysis of the Escherichia coli recO gene. J Bacteriol. 1989;171:3641-9 pubmed
    ..A combination of primary sequence analysis and secondary structure predictions suggested that recO contains a mononucleotide-binding fold. ..
  6. Bianchi A, Baneyx F. Hyperosmotic shock induces the sigma32 and sigmaE stress regulons of Escherichia coli. Mol Microbiol. 1999;34:1029-38 pubmed
  7. Kanehara K, Ito K, Akiyama Y. YaeL (EcfE) activates the sigma(E) pathway of stress response through a site-2 cleavage of anti-sigma(E), RseA. Genes Dev. 2002;16:2147-55 pubmed publisher
    ..Thus, YaeL is positively required for the sigma(E) extracytoplasmic stress response...