Gene Symbol: rplQ
Description: 50S ribosomal subunit protein L17
Alias: ECK3281, JW3256
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Isono K, Krauss J, Hirota Y. Isolation and characterization of temperature-sensitive mutants of Escherichia coli with altered ribosomal proteins. Mol Gen Genet. 1976;149:297-302 pubmed
    ..The importance of these mutants for structural and functional analyses of ribosomes is discussed. ..
  2. Brosius J, Schiltz E, Chen R. The primary structure of the 5S RNA binding protein L18 from Escherichia coli ribosomes. FEBS Lett. 1975;56:359-61 pubmed
  3. Jaskunas S, Burgess R, Nomura M. Identification of a gene for the alpha-subunit of RNA polymerase at the str-spc region of the Escherichia coli chromosome. Proc Natl Acad Sci U S A. 1975;72:5036-40 pubmed
    ..7.7.6) has been identified and mapped between spcA and trkA, near 64 min on the E. coli chromosome. It appears to be coordinately expressed and possibly cotranscribed with the genes for ribosomal proteins S11, S4, and L17. ..
  4. Lindahl L, Sor F, Archer R, Nomura M, Zengel J. Transcriptional organization of the S10, spc and alpha operons of Escherichia coli. Biochim Biophys Acta. 1990;1050:337-42 pubmed
    ..In contrast, most or all RNA polymerases transcribing the spc operon continued into the alpha operon. Nevertheless, we observed that about 30% of the transcripts of the alpha operon were initiated at the alpha operon promoter. ..
  5. Bischof O, Urlaub H, Kruft V, Wittmann Liebold B. Peptide environment of the peptidyl transferase center from Escherichia coli 70 S ribosomes as determined by thermoaffinity labeling with dihydrospiramycin. J Biol Chem. 1995;270:23060-4 pubmed
    ..This approach is a valuable tool to characterize the binding site of spiramycin as well as the peptidyl transferase center at the molecular level. ..
  6. Hauber D, Grogan D, DeBry R. Mutations to Less-Preferred Synonymous Codons in a Highly Expressed Gene of Escherichia coli: Fitness and Epistatic Interactions. PLoS ONE. 2016;11:e0146375 pubmed publisher
    ..five specific 3rd-codon-position (silent) sites in the highly expressed Escherichia coli ribosomal protein gene rplQ from the wild type to a less-preferred alternative. We introduced the five mutations within a 10-codon region...
  7. Osswald M, Greuer B, Brimacombe R. Localization of a series of RNA-protein cross-link sites in the 23S and 5S ribosomal RNA from Escherichia coli, induced by treatment of 50S subunits with three different bifunctional reagents. Nucleic Acids Res. 1990;18:6755-60 pubmed
    ..Cross-links to 5S RNA were observed with L5 (positions 34-41), and L18 (precise site not localised). ..
  8. Bedwell D, Davis G, Gosink M, Post L, Nomura M, Kestler H, et al. Nucleotide sequence of the alpha ribosomal protein operon of Escherichia coli. Nucleic Acids Res. 1985;13:3891-903 pubmed
    ..We report here the complete 3.0 kb nucleotide sequence of the alpha operon. In addition, we have determined by S1 nuclease mapping the site of transcription termination in this operon. ..
  9. Post L, Arfsten A, Davis G, Nomura M. DNA sequence of the promoter region for the alpha ribosomal protein operon in Escherichia coli. J Biol Chem. 1980;255:4653-59 pubmed
    ..of the alpha operon and the gene order is promoter (P alpha), rpsM (S13), rpsK (S11), rpsD(S4), rpoA(alpha), and rplQ(L17). The DNA sequence extending 650 bases before S13 gene was determined...

More Information


  1. Metspalu E, Maimets T, Ustav M, Villems R. A quaternary complex consisting of two molecules of tRNA and ribosomal proteins L2 and L17. FEBS Lett. 1981;132:105-8 pubmed
  2. Cerretti D, Dean D, Davis G, Bedwell D, Nomura M. The spc ribosomal protein operon of Escherichia coli: sequence and cotranscription of the ribosomal protein genes and a protein export gene. Nucleic Acids Res. 1983;11:2599-616 pubmed
  3. Meek D, Hayward R. Nucleotide sequence of the rpoA-rplQ DNA of Escherichia coli: a second regulatory binding site for protein S4?. Nucleic Acids Res. 1984;12:5813-21 pubmed
    ..with their products named in brackets): rpsM (S13), rpsK (S11), rpsD (S4), rpoA (alpha-subunit of RNA polymerase), rplQ (L17)...
  4. Hoving S, Munchbach M, Schmid H, Signor L, Lehmann A, Staudenmann W, et al. A method for the chemical generation of N-terminal peptide sequence tags for rapid protein identification. Anal Chem. 2000;72:1006-14 pubmed
    ..We show that chemical tagging is a viable first-pass high-throughput identification method to be used prior to an in depth MS/MS analysis. ..
  5. Semrad K, Green R, Schroeder R. RNA chaperone activity of large ribosomal subunit proteins from Escherichia coli. RNA. 2004;10:1855-60 pubmed
    ..Nearly a third of the 34 large ribosomal subunit proteins displayed RNA chaperone activity. We discuss a possible role of this function during ribosome assembly and during translation. ..