rodZ

Summary

Gene Symbol: rodZ
Description: MreB assembly cytoskeletal protein
Alias: ECK2512, JW2500, yfgA
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Bendezú F, Hale C, Bernhardt T, de Boer P. RodZ (YfgA) is required for proper assembly of the MreB actin cytoskeleton and cell shape in E. coli. EMBO J. 2009;28:193-204 pubmed publisher
    ..In a new genetic screen for cell shape mutants, we identified RodZ (YfgA) as an important transmembrane component of the cytoskeleton...
  2. Alyahya S, Alexander R, Costa T, Henriques A, Emonet T, Jacobs Wagner C. RodZ, a component of the bacterial core morphogenic apparatus. Proc Natl Acad Sci U S A. 2009;106:1239-44 pubmed publisher
    ..Here we discover a morphogenic protein, RodZ, which is widely conserved across the bacterial kingdom...
  3. Shiomi D, Toyoda A, Aizu T, Ejima F, Fujiyama A, Shini T, et al. Mutations in cell elongation genes mreB, mrdA and mrdB suppress the shape defect of RodZ-deficient cells. Mol Microbiol. 2013;87:1029-44 pubmed publisher
    b>RodZ interacts with MreB and both factors are required to maintain the rod shape of Escherichia coli...
  4. Shiomi D, Sakai M, Niki H. Determination of bacterial rod shape by a novel cytoskeletal membrane protein. EMBO J. 2008;27:3081-91 pubmed publisher
    ..Here, we report a novel gene, rodZ, required for the determination of rod shape in Escherichia coli...
  5. Niba E, Li G, Aoki K, Kitakawa M. Characterization of rodZ mutants: RodZ is not absolutely required for the cell shape and motility. FEMS Microbiol Lett. 2010;309:35-42 pubmed publisher
    RodZ (YfgA) is a membrane protein well conserved among bacterial species and important in the determination of cell shape and motility, although the molecular mechanism involved is not well established...
  6. Shiomi D, Mori H, Niki H. Genetic mechanism regulating bacterial cell shape and metabolism. Commun Integr Biol. 2009;2:219-20 pubmed
    ..A recent paper reported the genetic regulation of the cell length by rodZ. RodZ is a membrane protein with bitopic topology that assembles underneath the cell membrane to form helical ..
  7. Baker J, Franklin D, Parker J. Sequence and characterization of the gcpE gene of Escherichia coli. FEMS Microbiol Lett. 1992;73:175-80 pubmed
    ..The probable transcription terminator of gcpE overlaps the hisS promoter. Haploid cells containing a disrupted gcpE could not be obtained, suggesting that the gcpE gene is essential. ..
  8. Jacques P, Rodrigue S, Gaudreau L, Goulet J, Brzezinski R. Detection of prokaryotic promoters from the genomic distribution of hexanucleotide pairs. BMC Bioinformatics. 2006;7:423 pubmed
    ..Importantly, our methodology could also be adapted to identify DNA sequences recognized by other regulatory proteins. ..
  9. Talukder A, Yanai S, Yamada M. Analysis of products of the Escherichia coli genomic genes and regulation of their expressions: an applicable procedure for genomic analysis of other microorganisms. Biosci Biotechnol Biochem. 1994;58:117-20 pubmed
    ..These results suggest that this library is useful for the global analysis of the E. coli genomic genes and that this strategy may be applicable to the genomic analysis of other microorganisms. ..

More Information

Publications21

  1. Wang S, Yang C, Shan S. SecA mediates cotranslational targeting and translocation of an inner membrane protein. J Cell Biol. 2017;216:3639-3653 pubmed publisher
    ..In this study, we show that SecA cotranslationally recognizes the nascent chain of an inner membrane protein, RodZ, with high affinity and specificity...
  2. Porter T, Frederick D, Johnson E, Jones P. A requirement for cell elongation protein RodZ and cell division proteins FtsN and DedD to maintain the small rod morphology of Escherichia coli at growth temperatures near 8°C. J Gen Appl Microbiol. 2016;62:189-98 pubmed publisher
    ..In contrast to cell division protein DedD, RodZ is a cell elongation protein particularly required for growth at 30°C...
  3. Morgenstein R, Bratton B, Nguyen J, Ouzounov N, Shaevitz J, Gitai Z. RodZ links MreB to cell wall synthesis to mediate MreB rotation and robust morphogenesis. Proc Natl Acad Sci U S A. 2015;112:12510-5 pubmed publisher
    ..Here we demonstrate that the transmembrane protein RodZ mediates MreB rotation by directly or indirectly coupling MreB to cell wall synthesis enzymes...
  4. Gerdes K. RodZ, a new player in bacterial cell morphogenesis. EMBO J. 2009;28:171-2 pubmed publisher
  5. Niba E, Naka Y, Nagase M, Mori H, Kitakawa M. A genome-wide approach to identify the genes involved in biofilm formation in E. coli. DNA Res. 2007;14:237-46 pubmed publisher
    ..Characterization of the nine mutants of function-unknown genes indicated that some of them, such as yfgA that genetically interacts with a periplasmic chaperone gene surA together with yciB and yciM, might be required ..
  6. Kurono N, Matsuda A, Etchuya R, Sobue R, Sasaki Y, Ito M, et al. Genome-wide screening of Escherichia coli genes involved in execution and promotion of cell-to-cell transfer of non-conjugative plasmids: rodZ (yfgA) is essential for plasmid acceptance in recipient cells. Biochem Biophys Res Commun. 2012;421:119-23 pubmed publisher
    ..The other essential gene was rodZ (yfgA), a gene involved in the regulation of rod-shaped structure of E. coli cells...
  7. Altincicek B, Kollas A, Sanderbrand S, Wiesner J, Hintz M, Beck E, et al. GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. J Bacteriol. 2001;183:2411-6 pubmed
    ..These cells were then deleted for the essential gcpE gene and were viable only if the medium was supplemented with mevalonate or the cells were complemented with an episomal copy of gcpE. ..
  8. Baker J, Parker J. Sequence and characterization of the Escherichia coli genome between the ndk and gcpE genes. FEMS Microbiol Lett. 1994;121:293-6 pubmed
    ..A., Yanai, S., and Yamada, M. (1994) Biosci. Biotech. Biochem. 58, 117-120) indicate that orf 337 is in an operon with gcpE. The gene orf 384 is immediately downstream of the gene ndk, which encodes nucleoside diphosphate kinase. ..
  9. Shiomi D, Niki H. A mutation in the promoter region of zipA, a component of the divisome, suppresses the shape defect of RodZ-deficient cells. Microbiologyopen. 2013;2:798-810 pubmed publisher
    b>RodZ is important for maintaining the rod shape of Escherichia coli. Loss of RodZ causes conversion of the rod shape to a round shape and a growth rate slower than that of wild-type cells...
  10. Jovanovic G, Mehta P, Ying L, Buck M. Anionic lipids and the cytoskeletal proteins MreB and RodZ define the spatio-temporal distribution and function of membrane stress controller PspA in Escherichia coli. Microbiology. 2014;160:2374-86 pubmed publisher
    ..effector(s) in lateral membrane regions depend on the actin homologue MreB and the peptidoglycan machinery protein RodZ. The consequences of loss of cytoplasmic membrane anionic lipids, MreB, RodZ and/or YqiK suggest that the mode of ..
  11. Newitt J, Ulbrandt N, Bernstein H. The structure of multiple polypeptide domains determines the signal recognition particle targeting requirement of Escherichia coli inner membrane proteins. J Bacteriol. 1999;181:4561-7 pubmed
  12. Govindarajan S, Amster Choder O. The bacterial Sec system is required for the organization and function of the MreB cytoskeleton. PLoS Genet. 2017;13:e1007017 pubmed publisher
    ..Thus, when we reroute RodZ, MreB membrane-anchor, by fusing it to a SecA-independent integral membrane protein and overproducing it, MreB ..