Gene Symbol: rhlE
Description: ATP-dependent RNA helicase
Alias: ECK0786, JW0781
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Raynal L, Carpousis A. Poly(A) polymerase I of Escherichia coli: characterization of the catalytic domain, an RNA binding site and regions for the interaction with proteins involved in mRNA degradation. Mol Microbiol. 1999;32:765-75 pubmed
    ..Additional protein-protein interactions were detected between PAP I and CsdA, RhlE and SrmB, suggesting an unexpected connection between PAP I and these E. coli DEAD box RNA helicases...
  2. Bizebard T, Ferlenghi I, Iost I, Dreyfus M. Studies on three E. coli DEAD-box helicases point to an unwinding mechanism different from that of model DNA helicases. Biochemistry. 2004;43:7857-66 pubmed
    ..We have compared the ATPase and helicase activities of three E. coli DEAD-box proteins, CsdA, RhlE and SrmB...
  3. Khemici V, Toesca I, Poljak L, Vanzo N, Carpousis A. The RNase E of Escherichia coli has at least two binding sites for DEAD-box RNA helicases: functional replacement of RhlB by RhlE. Mol Microbiol. 2004;54:1422-30 pubmed
    ..We show that three other DEAD-box helicases, SrmB, RhlE and CsdA also bind to RNase E in vitro...
  4. Ohmori H. Structural analysis of the rhlE gene of Escherichia coli. Jpn J Genet. 1994;69:1-12 pubmed
    ..We here report the complete nucleotide sequence of the remaining rhlE gene located at about 17.8 min on the E. coli genetic map...
  5. Marcaida M, DePristo M, Chandran V, Carpousis A, Luisi B. The RNA degradosome: life in the fast lane of adaptive molecular evolution. Trends Biochem Sci. 2006;31:359-65 pubmed
  6. Awano N, Xu C, Ke H, Inoue K, Inouye M, Phadtare S. Complementation analysis of the cold-sensitive phenotype of the Escherichia coli csdA deletion strain. J Bacteriol. 2007;189:5808-15 pubmed
    ..an in vivo counterpart of CsdA that can compensate for its absence at low temperature revealed only one protein, RhlE, another DEAD-box RNA helicase...
  7. Jain C. The E. coli RhlE RNA helicase regulates the function of related RNA helicases during ribosome assembly. RNA. 2008;14:381-9 pubmed
    ..four of these proteins have been implicated in RNA turnover or ribosome biogenesis, no cellular function for the RhlE DEAD-box protein has been described as yet...
  8. Polissi A, De Laurentis W, Zangrossi S, Briani F, Longhi V, Pesole G, et al. Changes in Escherichia coli transcriptome during acclimatization at low temperature. Res Microbiol. 2003;154:573-80 pubmed
    ..Interestingly, we found that PNPase both negatively and positively modulated the transcript abundance of some of these genes, thus suggesting a complex role of PNPase in controlling cold adaptation. ..
  9. Iost I, Dreyfus M. DEAD-box RNA helicases in Escherichia coli. Nucleic Acids Res. 2006;34:4189-97 pubmed
    ..Altogether, several aspects of the information gathered with these proteins have become paradigms for our understanding of DEAD-box proteins in general. ..

More Information


  1. Kalman M, Murphy H, Cashel M. rhlB, a new Escherichia coli K-12 gene with an RNA helicase-like protein sequence motif, one of at least five such possible genes in a prokaryote. New Biol. 1991;3:886-95 pubmed
    ..The multiplicity of such genes in a prokaryote raises the possibility of important roles for the corresponding class of biologically widespread proteins. ..
  2. Shundyak K, van Roij R. Isotropic-nematic transition in hard-rod fluids: relation between continuous and restricted-orientation models. Phys Rev E Stat Nonlin Soft Matter Phys. 2004;69:041703 pubmed
    ..For a binary mixture this artificial phase also exists, and a much larger number of orientations is required to shift it to such high densities that it does not interfere with the physical part of the phase diagram. ..
  3. Worrall J, Howe F, McKay A, Robinson C, Luisi B. Allosteric activation of the ATPase activity of the Escherichia coli RhlB RNA helicase. J Biol Chem. 2008;283:5567-76 pubmed publisher
    ..For comparisons, corresponding mutations were prepared in two other E. coli DEAD box ATPases, RhlE and SrmB...