recF

Summary

Gene Symbol: recF
Description: gap repair protein
Alias: ECK3692, JW3677, uvrF
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Ciesla Z, O BRIEN P, Clark A. Genetic analysis of UV mutagenesis of the Escherichia coli glyU gene. Mol Gen Genet. 1987;207:1-8 pubmed
    ..When carried by M13 phage mp9, glyU is subject to induced UV mutagenesis which is dependent on the umuC+ and recF+ genes. When carried by M13 phage mp8, glyU is not subject to induced UV mutagenesis...
  2. Rudd K, Menzel R. his operons of Escherichia coli and Salmonella typhimurium are regulated by DNA supercoiling. Proc Natl Acad Sci U S A. 1987;84:517-21 pubmed
    ..Several lines of evidence, including high transduction linkage to recF, suggest that hisU1820 is an allele of gyrB. Finally, well-characterized gyrA and gyrB alleles of E...
  3. Chan A, Nagel R. Involvement of recA and recF in the induced precise excision of Tn10 in Escherichia coli. Mutat Res. 1997;381:111-5 pubmed
    ..The effect of a null recF mutation on the excision of Tn10 in a uvrD- mutant was also investigated and found to abolish the increased ..
  4. Morimatsu K, Kowalczykowski S. RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: a universal step of recombinational repair. Mol Cell. 2003;11:1337-47 pubmed
    Genetic evidence suggests that the RecF, RecO, and RecR (RecFOR) proteins participate in a common step of DNA recombination and repair, yet the biochemical event requiring collaboration of all three proteins is unknown...
  5. Grompone G, Sanchez N, Dusko Ehrlich S, Michel B. Requirement for RecFOR-mediated recombination in priA mutant. Mol Microbiol. 2004;52:551-62 pubmed
    ..Models for the formation of single strand DNA gaps consequently to a replication restart defect and for gap processing are proposed. ..
  6. Nowosielska A, Calmann M, Zdraveski Z, Essigmann J, Marinus M. Spontaneous and cisplatin-induced recombination in Escherichia coli. DNA Repair (Amst). 2004;3:719-28 pubmed
    ..Inactivation of the recF, recO, recR and recJ genes decreased cisplatin-induced, but not spontaneous, recombination...
  7. Kowalczykowski S, Dixon D, Eggleston A, Lauder S, Rehrauer W. Biochemistry of homologous recombination in Escherichia coli. Microbiol Rev. 1994;58:401-65 pubmed
    ..At present, this includes the RecA, RecBCD (exonuclease V), RecE (exonuclease VIII), RecF, RecG, RecJ, RecN, RecOR, RecQ, RecT, RuvAB, RuvC, SbcCD, and SSB proteins, as well as DNA polymerase I, DNA gyrase,..
  8. Gillen J, Willis D, Clark A. Genetic analysis of the RecE pathway of genetic recombination in Escherichia coli K-12. J Bacteriol. 1981;145:521-32 pubmed
    ..In addition, strain construction and mutagenesis revealed the dependence of the RecE pathway on recA+ and on recF+. Dependence on a fourth gene was shown by a mutation (rec-77) which does not map near the other genes...
  9. Courcelle J, Carswell Crumpton C, Hanawalt P. recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli. Proc Natl Acad Sci U S A. 1997;94:3714-9 pubmed
    Escherichia coli containing a mutation in recF are hypersensitive to UV. However, they exhibit normal levels of conjugational or transductional recombination unless the major pathway (recBC) is defective...

More Information

Publications79

  1. Kim S, Pytlos M, Sinden R. Replication restart: a pathway for (CTG).(CAG) repeat deletion in Escherichia coli. Mutat Res. 2006;595:5-22 pubmed
    ..Mutations in priB and priC resulted in small reductions in deletion rates. In a recF strain, rates were decreased when (CAG)n comprised the leading template strand, but rates were increased when (CTG)..
  2. Xu L, Marians K. PriA mediates DNA replication pathway choice at recombination intermediates. Mol Cell. 2003;11:817-26 pubmed
    ..this recombination-directed DNA replication reaction, and that this stimulation is modulated by the presence of RecF, suggesting that the latter protein may also act as a regulator of the pathway of resolution of the recombination ..
  3. Sharan R, Ryo H, Nomura T. Critical role of RecA and RecF proteins in strand break rejoining and maintenance of fidelity of rejoining following gamma-radiation-induced damage to pMTa4 DNA in E. coli. Int J Radiat Biol. 2007;83:89-97 pubmed
    This study was undertaken to understand the roles of RecA and RecF proteins in strand break rejoining and maintenance of fidelity of the process following exposure of E. coli to gamma-radiation in vivo...
  4. Payne B, van Knippenberg I, Bell H, Filipe S, Sherratt D, McGlynn P. Replication fork blockage by transcription factor-DNA complexes in Escherichia coli. Nucleic Acids Res. 2006;34:5194-202 pubmed
    ..However, neither RuvABC nor RecF were needed for normal cell growth in the face of such complexes...
  5. Macian F, Perez Roger I, Armengod M. An improved vector system for constructing transcriptional lacZ fusions: analysis of regulation of the dnaA, dnaN, recF and gyrB genes of Escherichia coli. Gene. 1994;145:17-24 pubmed
    ..We use this system to compare the transcriptional activities of the promoters present in the dnaA-dnaN-recF-gyrB cluster. The order of strength of these promoters is gyrB > dnaA > recF > dnaN...
  6. Umezu K, Chi N, Kolodner R. Biochemical interaction of the Escherichia coli RecF, RecO, and RecR proteins with RecA protein and single-stranded DNA binding protein. Proc Natl Acad Sci U S A. 1993;90:3875-9 pubmed
    The Escherichia coli RecF, RecO, and RecR proteins were analyzed for their effect on RecA-mediated pairing of single-stranded circular DNA and homologous linear duplex DNA substrates...
  7. Sandler S, Clark A. Mutational analysis of sequences in the recF gene of Escherichia coli K-12 that affect expression. J Bacteriol. 1994;176:4011-6 pubmed
    The level of translation of recF-lacZ fusions is reduced 20-fold by nucleotides 49 to 146 of recF...
  8. Sukhodolets V, Botina S, Trenina M, Ukhabotina L. [Homologous recombination and chromosomal rearrangements in Escherichia coli strains carrying a heterozygous tandem duplication]. Genetika. 2001;37:591-601 pubmed
    ..recombination between homologous DNA repeats was very high in all strains and did not decrease when the RecBCD and RecF recombinational pathways were simultaneously damaged in strains with the recB sbcBC recQ (or recF) genotype...
  9. Ivancić Bacće I, Vlasic I, Cogelja Cajo G, Brcic Kostic K, Salaj Smic E. Roles of PriA protein and double-strand DNA break repair functions in UV-induced restriction alleviation in Escherichia coli. Genetics. 2006;174:2137-49 pubmed
    ..On the basis of our results, we propose that unmethylated target sequences are generated at the D-loop by the strand exchange of two hemi-methylated duplex DNAs and subsequent initiation of DNA replication. ..
  10. Grigorian A, Lustig R, Guzmán E, Mahaffy J, Zyskind J. Escherichia coli cells with increased levels of DnaA and deficient in recombinational repair have decreased viability. J Bacteriol. 2003;185:630-44 pubmed
    The dnaA operon of Escherichia coli contains the genes dnaA, dnaN, and recF encoding DnaA, beta clamp of DNA polymerase III holoenzyme, and RecF...
  11. Ream L, Clark A. Cloning and deletion mapping of the recF dnaN region of the Escherichia coli chromosome. Plasmid. 1983;10:101-10 pubmed
    By cloning a 3.6-kb EcoRI fragment of the Escherichia coli chromosome with pBR322 we located more precisely recF relative to dnaN. By deletion mapping we localized functional recF to a 1...
  12. Handa N, Ichige A, Kobayashi I. Contribution of RecFOR machinery of homologous recombination to cell survival after loss of a restriction-modification gene complex. Microbiology. 2009;155:2320-32 pubmed publisher
    ..A recF mutation reduced survival in an otherwise rec-positive background and, more severely, in a recBC sbcBC background...
  13. Lopez E, Elez M, Matic I, Blazquez J. Antibiotic-mediated recombination: ciprofloxacin stimulates SOS-independent recombination of divergent sequences in Escherichia coli. Mol Microbiol. 2007;64:83-93 pubmed
  14. Clark A, Sandler S. Homologous genetic recombination: the pieces begin to fall into place. Crit Rev Microbiol. 1994;20:125-42 pubmed
    ..This in turn led to the discovery of several genes, including recF, recO, and recR, whose role in recombination would not otherwise have been detected...
  15. Perez Roger I, García Sogo M, Navarro Avino J, López Acedo C, Macian F, Armengod M. Positive and negative regulatory elements in the dnaA-dnaN-recF operon of Escherichia coli. Biochimie. 1991;73:329-34 pubmed
    The recF gene of E coli lies within a cluster of genes which play essential roles in DNA replication; the gene order is dnaA dnaN recF gyrB...
  16. Cromie G, Leach D. Recombinational repair of chromosomal DNA double-strand breaks generated by a restriction endonuclease. Mol Microbiol. 2001;41:873-83 pubmed
  17. Handa N, Morimatsu K, Lovett S, Kowalczykowski S. Reconstitution of initial steps of dsDNA break repair by the RecF pathway of E. coli. Genes Dev. 2009;23:1234-45 pubmed publisher
    The RecF pathway of Escherichia coli is important for recombinational repair of DNA breaks and gaps...
  18. Griffin T, Kolodner R. Purification and preliminary characterization of the Escherichia coli K-12 recF protein. J Bacteriol. 1990;172:6291-9 pubmed
    The recF gene of Escherichia coli is known to encode an Mr-40,000 protein that is involved in DNA recombinationa nd postreplication DNA repair...
  19. Lestini R, Michel B. UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR in a rep mutant of Escherichia coli. J Bacteriol. 2008;190:5995-6001 pubmed publisher
    ..lethality of rep and uvrD inactivation is suppressed in the absence of the recombination presynaptic proteins RecF, RecO, or RecR, it was proposed that UvrD is essential in the rep mutant to counteract a deleterious RecFOR-..
  20. Asai T, Kogoma T. The RecF pathway of homologous recombination can mediate the initiation of DNA damage-inducible replication of the Escherichia coli chromosome. J Bacteriol. 1994;176:7113-4 pubmed
    ..These results indicate that the RecF pathway of homologous recombination can also catalyze iSDR initiation.
  21. Courcelle J. Recs preventing wrecks. Mutat Res. 2005;577:217-27 pubmed
    ..When this process is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication fork, allowing it to resume and ..
  22. Sandler S. Overlapping functions for recF and priA in cell viability and UV-inducible SOS expression are distinguished by dnaC809 in Escherichia coli K-12. Mol Microbiol. 1996;19:871-80 pubmed
    The recF and priA genes have roles in DNA repair and homologous recombination. Mutations in these genes also cause decreases in cell viability and alterations in UV-inducible sulAp-lacZ (SOS) expression...
  23. Villarroya M, Perez Roger I, Macian F, Armengod M. Stationary phase induction of dnaN and recF, two genes of Escherichia coli involved in DNA replication and repair. EMBO J. 1998;17:1829-37 pubmed
    ..The gene encoding beta, dnaN, maps between dnaA and recF, which are involved in initiation of DNA replication at oriC and resumption of DNA replication at disrupted ..
  24. Ikeda H, Shiraishi K, Ogata Y. Illegitimate recombination mediated by double-strand break and end-joining in Escherichia coli. Adv Biophys. 2004;38:3-20 pubmed
    ..RecE and RecT enhances the frequencies of spontaneous and UV-induced illegitimate recombination and that the RecJ, RecF, RecO, and RecR functions are required for this RecE-mediated illegitimate recombination...
  25. Ikeda H, Shiraishi K, Ogata Y. Illegitimate recombination mediated by double-strand break and end-joining in Escherichia coli. Adv Biophys. 2004;38:3-20 pubmed
    ..RecE and RecT enhances the frequencies of spontaneous and UV-induced illegitimate recombination and that the RecJ, RecF, RecO, and RecR functions are required for this RecE-mediated illegitimate recombination...
  26. Wang T, Madiraju M, Templin A, Clark A. Cloning and preliminary characterization of srf-2020 and srf-801, the recF partial suppressor mutations which map in recA of Escherichia coli K-12. Biochimie. 1991;73:335-40 pubmed
    We have located the single nucleotide changes suffered in recA sequence of 2 recF partial suppressor mutations: srf-2020 at codon 121 and srf-801 at codon 257. srf-2020 changes codon 121 from threonine (ACC) to isoleucine (ATC)...
  27. Madiraju M, Templin A, Clark A. Properties of a mutant recA-encoded protein reveal a possible role for Escherichia coli recF-encoded protein in genetic recombination. Proc Natl Acad Sci U S A. 1988;85:6592-6 pubmed
    ..DNA binding protein is the property that allows recA803 to suppress partially the deficiency in repair caused by recF mutations in the uvrA6 background...
  28. Seigneur M, Ehrlich S, Michel B. recD sbcB sbcD mutants are deficient in recombinational repair of UV lesions by RecBC. J Bacteriol. 1999;181:6220-1 pubmed
    In recD sbcB sbcD mutants, repair of UV-irradiated DNA is strongly RecF dependent, indicating that RecBC is inactive...
  29. Whitby M, Lloyd R. Altered SOS induction associated with mutations in recF, recO and recR. Mol Gen Genet. 1995;246:174-9 pubmed
    ..Induction of the SOS response is dependent on RecA and also on the product of recF. We show that normal induction also requires the products of recO and recR...
  30. Webb B, Cox M, Inman R. Recombinational DNA repair: the RecF and RecR proteins limit the extension of RecA filaments beyond single-strand DNA gaps. Cell. 1997;91:347-56 pubmed
    In the presence of both the RecF and RecR proteins, RecA filament extension from a single strand gap into adjoining duplex DNA is attenuated. RecR protein alone has no effect, and RecF protein alone has a reduced activity...
  31. Ream L, Margossian L, Clark A, Hansen F, von Meyenburg K. Genetic and physical mapping of recF in Escherichia coli K-12. Mol Gen Genet. 1980;180:115-21 pubmed
    Two factor transductional crosses place recF at approximately 82 min on the E. coli chromosome; recF is highly cotransducible with dnaA and gyrB (cou)...
  32. Umezu K, Kolodner R. Protein interactions in genetic recombination in Escherichia coli. Interactions involving RecO and RecR overcome the inhibition of RecA by single-stranded DNA-binding protein. J Biol Chem. 1994;269:30005-13 pubmed
    ..To elucidate the mechanism that underlies this process, we examined protein-protein interactions between RecA, RecF, RecO, RecR, and SSB, and characterized the structure and activity of the ssDNA complexes formed with different ..
  33. Adam E, Volkert M, Blot M. Cytochrome c biogenesis is involved in the transposon Tn5-mediated bleomycin resistance and the associated fitness effect in Escherichia coli. Mol Microbiol. 1998;28:15-24 pubmed
    ..Inactivation of potent DNA oxidants confers a better fitness to the bacterium carrying the transposon, suggesting a symbiotic relationship between host and transposon. ..
  34. Blanar M, Sandler S, Armengod M, Ream L, Clark A. Molecular analysis of the recF gene of Escherichia coli. Proc Natl Acad Sci U S A. 1984;81:4622-6 pubmed
    We analyzed the nucleotide sequence of a 1.325-kilobase region of wild-type Escherichia coli containing a functional recF gene and six Tn3 mutations that inactivate recF...
  35. Armengod M. Role of the recF gene of Escherichia coli K-12 in lambda recombination. Mol Gen Genet. 1981;181:497-504 pubmed
    ..phage, which are unable to replicate, general recombination between phage and prophage depends on the bacterial recF gene. It has been shown that in E...
  36. Clark A. rec genes and homologous recombination proteins in Escherichia coli. Biochimie. 1991;73:523-32 pubmed
    ..The genes are usually grouped into three pathways named RecBCD, RecE and RecF for prominent genes which function in each...
  37. Volkert M, Margossian L, Clark A. Two-component suppression of recF143 by recA441 in Escherichia coli K-12. J Bacteriol. 1984;160:702-5 pubmed
    ..This is thought to indicate that recA441 also caused temperature-independent changes in recA activity. Two hypotheses are offered to explain how recA441 produced both thermosensitive and thermoindependent effects. ..
  38. Quinones A, Messer W. Discoordinate gene expression in the dnaA-dnaN operon of Escherichia coli. Mol Gen Genet. 1988;213:118-24 pubmed
    ..These results are consistent with the hypothesis that although dnaA and dnaN are organized in an operon considerable discoordinate transcription can occur, thus uncoupling dnaN and dnaA regulation, when needed. ..
  39. Zahradka K, Simic S, Buljubasic M, Petranovic M, Dermic D, Zahradka D. sbcB15 And DeltasbcB mutations activate two types of recf recombination pathways in Escherichia coli. J Bacteriol. 2006;188:7562-71 pubmed
    ..This phenotype can be corrected by suppressor mutations in sbcB and sbcC(D) genes, which activate an alternative RecF pathway of recombination...
  40. Fujii S, Isogawa A, Fuchs R. RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis. EMBO J. 2006;25:5754-63 pubmed
    ..A positive contribution of RecF protein to Pol V lesion bypass is demonstrated...
  41. Rudolph C, Upton A, Lloyd R. Maintaining replication fork integrity in UV-irradiated Escherichia coli cells. DNA Repair (Amst). 2008;7:1589-602 pubmed publisher
    ..Instead, nascent strands may be protected by the simple expedient of promoting restart. We also report that the efficiency of fork reactivation is not affected in polB mutants. ..
  42. Nowosielska A, Smith S, Engelward B, Marinus M. Homologous recombination prevents methylation-induced toxicity in Escherichia coli. Nucleic Acids Res. 2006;34:2258-68 pubmed
    ..We find that recombination-deficient cell lines, such as recBCD recF, and ruvC recG, are as sensitive to the cytotoxic effects of MMS and MNNG as the most base excision repair (BER)-..
  43. Lusetti S, Hobbs M, Stohl E, Chitteni Pattu S, Inman R, Seifert H, et al. The RecF protein antagonizes RecX function via direct interaction. Mol Cell. 2006;21:41-50 pubmed
    The RecX protein inhibits RecA filament extension, leading to net filament disassembly. The RecF protein physically interacts with the RecX protein and protects RecA from the inhibitory effects of RecX...
  44. Magner D, Blankschien M, Lee J, Pennington J, Lupski J, Rosenberg S. RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins. Mol Cell. 2007;26:273-86 pubmed
    ..Death and segregation failure require RecA and RecF strand exchange proteins...
  45. Ivancic Bace I, Salaj Smic E, Brcic Kostic K. Effects of recJ, recQ, and recFOR mutations on recombination in nuclease-deficient recB recD double mutants of Escherichia coli. J Bacteriol. 2005;187:1350-6 pubmed
    The two main recombination pathways in Escherichia coli (RecBCD and RecF) have different recombination machineries that act independently in the initiation of recombination...
  46. Sandler S, Chackerian B, Li J, Clark A. Sequence and complementation analysis of recF genes from Escherichia coli, Salmonella typhimurium, Pseudomonas putida and Bacillus subtilis: evidence for an essential phosphate binding loop. Nucleic Acids Res. 1992;20:839-45 pubmed
    We have compared the recF genes from Escherichia coli K-12, Salmonella typhimurium, Pseudomonas putida, and Bacillus subtilis at the DNA and amino acid sequence levels...
  47. Pollard L, Chutake Y, Rindler P, Bidichandani S. Deficiency of RecA-dependent RecFOR and RecBCD pathways causes increased instability of the (GAA*TTC)n sequence when GAA is the lagging strand template. Nucleic Acids Res. 2007;35:6884-94 pubmed
    ..Our data implicate defective processing of stalled replication forks as a mechanism for genetic instability of the (GAA*TTC)n sequence. ..
  48. Viguera E, Petranovic M, Zahradka D, Germain K, Ehrlich D, Michel B. Lethality of bypass polymerases in Escherichia coli cells with a defective clamp loader complex of DNA polymerase III. Mol Microbiol. 2003;50:193-204 pubmed
  49. Hiom K. DNA repair: common approaches to fixing double-strand breaks. Curr Biol. 2009;19:R523-5 pubmed publisher
    In bacteria, the RecF pathway plays an important role in the repair of DNA breaks and gaps. Reconstitution of this reaction in vitro has revealed similarities with double-strand break repair in eukaryotes.
  50. Hegde S, Rajagopalan M, Madiraju M. Preferential binding of Escherichia coli RecF protein to gapped DNA in the presence of adenosine (gamma-thio) triphosphate. J Bacteriol. 1996;178:184-90 pubmed
    Escherichia coli RecF protein binds, but does not hydrolyze, ATP...
  51. Courcelle J, Hanawalt P. Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination. Proc Natl Acad Sci U S A. 2001;98:8196-202 pubmed
    ..Following UV irradiation, the recovery of DNA replication requires uvrA and uvrC, as well as recA, recF, and recR...
  52. Veaute X, Delmas S, Selva M, Jeusset J, Le Cam E, Matic I, et al. UvrD helicase, unlike Rep helicase, dismantles RecA nucleoprotein filaments in Escherichia coli. EMBO J. 2005;24:180-9 pubmed
    ..We reported earlier that mutations in recF, recO or recR genes suppress the lethality of uvrD rep, and proposed that an essential activity common to UvrD and ..
  53. Madiraju M, Lavery P, Kowalczykowski S, Clark A. Enzymatic properties of the RecA803 protein, a partial suppressor of recF mutations. Biochemistry. 1992;31:10529-35 pubmed
    The RecA803 protein suppresses the recombinational repair defect of recF mutations and displays enhanced joint molecule formation in vitro (Madiraju et al., 1988)...
  54. Madiraju M, Clark A. Effect of RecF protein on reactions catalyzed by RecA protein. Nucleic Acids Res. 1991;19:6295-300 pubmed
    b>RecF protein is one of at least three single strand DNA (ssDNA) binding proteins which act in recombination and repair in Escherichia coli...
  55. Chow K, Courcelle J. RecO acts with RecF and RecR to protect and maintain replication forks blocked by UV-induced DNA damage in Escherichia coli. J Biol Chem. 2004;279:3492-6 pubmed
    In Escherichia coli, recF and recR are required to stabilize and maintain replication forks arrested by UV-induced DNA damage...
  56. Bichara M, Pinet I, Origas M, Fuchs R. Inactivation of recG stimulates the RecF pathway during lesion-induced recombination in E. coli. DNA Repair (Amst). 2006;5:129-37 pubmed
    ..Formation of recombinants is entirely RecA-dependent, the RecF and RecBCD sub-pathways accounting for about 2/3 and 1/3, respectively...
  57. Lovett S, Clark A. Genetic analysis of regulation of the RecF pathway of recombination in Escherichia coli K-12. J Bacteriol. 1983;153:1471-8 pubmed
    Genetic evidence is provided supporting the hypothesis that one or more genes of the RecF pathway of recombination other than recA are controlled by the lexA repressor...
  58. Kosa J, Zdraveski Z, Currier S, Marinus M, Essigmann J. RecN and RecG are required for Escherichia coli survival of Bleomycin-induced damage. Mutat Res. 2004;554:149-57 pubmed
    ..and recN, which lack proteins required for double strand break (DSB) repair, were highly sensitive to BLM, while recF cells were not...
  59. Yamanaka T, Toyoshiba H, Sone H, Parham F, Portier C. The TAO-Gen algorithm for identifying gene interaction networks with application to SOS repair in E. coli. Environ Health Perspect. 2004;112:1614-21 pubmed
    ..The method is used to evaluate interactions between genes in the SOS signaling pathway in Escherichia coli using gene expression data where each gene in the network is over-expressed using plasmids inserts. ..
  60. Al Hadid Q, Ona K, Courcelle C, Courcelle J. RecA433 cells are defective in recF-mediated processing of disrupted replication forks but retain recBCD-mediated functions. Mutat Res. 2008;645:19-26 pubmed publisher
    ..The cellular functions carried out by RecA require either recF pathway proteins or recBC pathway proteins to initiate RecA-loading onto the appropriate DNA substrates...
  61. Bianco P, Tracy R, Kowalczykowski S. DNA strand exchange proteins: a biochemical and physical comparison. Front Biosci. 1998;3:D570-603 pubmed
    ..coli, UvsX protein from Bacteriophage T4, and RAD51 protein from Saccharomyces cerevisiae. ..
  62. Handa N, Kobayashi I. Accumulation of large non-circular forms of the chromosome in recombination-defective mutants of Escherichia coli. BMC Mol Biol. 2003;4:5 pubmed
    ..ii) In a recBC sbcA background, in which RecE-mediated recombination is active, recA, recJ, recQ, recE, recT, recF, recO, and recR mutations led to their accumulation...
  63. Lin Q, Zhang C, Rikihisa Y. Analysis of involvement of the RecF pathway in p44 recombination in Anaplasma phagocytophilum and in Escherichia coli by using a plasmid carrying the p44 expression and p44 donor loci. Infect Immun. 2006;74:2052-62 pubmed
    ..Homologs of genes for the RecA-dependent RecF pathway, but not the RecBCD or RecE pathways, of recombination were detected in the A. phagocytophilum genome...
  64. Webb B, Cox M, Inman R. An interaction between the Escherichia coli RecF and RecR proteins dependent on ATP and double-stranded DNA. J Biol Chem. 1995;270:31397-404 pubmed
    The DNA binding and ATPase activities of RecF protein are modulated by RecR protein...
  65. Bork J, Cox M, Inman R. The RecOR proteins modulate RecA protein function at 5' ends of single-stranded DNA. EMBO J. 2001;20:7313-22 pubmed
    The Escherichia coli RecF, RecO and RecR pro teins have previously been implicated in bacterial recombinational DNA repair at DNA gaps...
  66. Adachi T, Mizuuchi M, Robinson E, Appella E, O Dea M, Gellert M, et al. DNA sequence of the E. coli gyrB gene: application of a new sequencing strategy. Nucleic Acids Res. 1987;15:771-84 pubmed
    ..A plausible terminator of gyrB transcription is located just beyond the structural gene. ..
  67. Hebert M, Wells R. Roles of double-strand breaks, nicks, and gaps in stimulating deletions of CTG.CAG repeats by intramolecular DNA repair. J Mol Biol. 2005;353:961-79 pubmed
    ..Double-strand break-induced instabilities were partially stabilized by a mutation in recF. Gaps of 30 nt formed a distinct 30 nt deletion product, whereas single strand nicks and gaps of 15 nt did not ..
  68. Webb B, Cox M, Inman R. ATP hydrolysis and DNA binding by the Escherichia coli RecF protein. J Biol Chem. 1999;274:15367-74 pubmed
    The Escherichia coli RecF protein possesses a weak ATP hydrolytic activity. ATP hydrolysis leads to RecF dissociation from double-stranded (ds)DNA...
  69. Bichara M, Fuchs R, Cordonnier A, Lambert I. Preferential post-replication repair of DNA lesions situated on the leading strand of plasmids in Escherichia coli. Mol Microbiol. 2009;71:305-14 pubmed publisher
    In Escherichia coli, RecF-dependent post-replication repair (PRR) permits cells to tolerate the potentially lethal effects of blocking lesions at the replication fork...
  70. Bidnenko V, Seigneur M, Penel Colin M, Bouton M, Dusko Ehrlich S, Michel B. sbcB sbcC null mutations allow RecF-mediated repair of arrested replication forks in rep recBC mutants. Mol Microbiol. 1999;33:846-57 pubmed
    ..that the combination of sbcB sbcCD null mutations restores the viability to rep recBC mutants by activation of the RecF pathway of recombination...