rcnA

Summary

Gene Symbol: rcnA
Description: membrane protein conferring nickel and cobalt resistance
Alias: ECK2099, JW2093, yohM
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Rodrigue A, Effantin G, Mandrand Berthelot M. Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli. J Bacteriol. 2005;187:2912-6 pubmed
    We report here on the isolation and primary characterization of the yohM gene of Escherichia coli. We show that yohM encodes a membrane-bound polypeptide conferring increased nickel and cobalt resistance in E. coli...
  2. Iwig J, Rowe J, Chivers P. Nickel homeostasis in Escherichia coli - the rcnR-rcnA efflux pathway and its linkage to NikR function. Mol Microbiol. 2006;62:252-62 pubmed
    ..Recently, a nickel and cobalt-efflux protein, RcnA, was identified in E. coli. This study examines the effect of RcnA on nickel homeostasis in E. coli...
  3. Koch D, Nies D, Grass G. The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis. Biometals. 2007;20:759-71 pubmed
    The transporter RcnA has previously been implicated in Ni(II) and Co(II) detoxification in E. coli probably through efflux...
  4. Iwig J, Leitch S, Herbst R, Maroney M, Chivers P. Ni(II) and Co(II) sensing by Escherichia coli RcnR. J Am Chem Soc. 2008;130:7592-606 pubmed publisher
    ..RcnR controls the expression of the metal efflux protein RcnA only in response to Ni(II) and Co(II) ions...
  5. Perrin C, Briandet R, Jubelin G, Lejeune P, Mandrand Berthelot M, Rodrigue A, et al. Nickel promotes biofilm formation by Escherichia coli K-12 strains that produce curli. Appl Environ Microbiol. 2009;75:1723-33 pubmed publisher
    ..Biofilm formation induced by nickel does not rely on efflux mechanisms using the RcnA pump, as these require a higher concentration of nickel to be activated...
  6. Blaha D, Arous S, Blériot C, Dorel C, Mandrand Berthelot M, Rodrigue A. The Escherichia coli metallo-regulator RcnR represses rcnA and rcnR transcription through binding on a shared operator site: Insights into regulatory specificity towards nickel and cobalt. Biochimie. 2011;93:434-9 pubmed publisher
    b>RcnA is an efflux pump responsible for Ni and Co detoxification in Escherichia coli. The expression of rcnA is induced by Ni and Co via the metallo-regulator RcnR...