phosphohistidine phosphatase


Gene Symbol: phosphohistidine phosphatase
Description: phosphohistidine phosphatase
Alias: ECK2334, JW2337, yfcW
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Ogino T, Matsubara M, Kato N, Nakamura Y, Mizuno T. An Escherichia coli protein that exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay. Mol Microbiol. 1998;27:573-85 pubmed
    ..We searched for a presumed phosphohistidine phosphatase, if present, which affects the function of the HPt domain through its dephosphorylation activity...
  2. Hamada K, Kato M, Mizuno T, Hakoshima T. Crystallographic characterization of a novel protein SixA which exhibits phospho-histidine phosphatase activity in the multistep His-Asp phosphorelay. Acta Crystallogr D Biol Crystallogr. 1999;55:269-71 pubmed
    ..26, b = 48.62 and c = 83.18 A, having one molecule in the crystallographic asymmetric unit. The intensity data were collected up to 1.5 A resolution using synchrotron radiation. ..
  3. Matsubara M, Mizuno T. EnvZ-independent phosphotransfer signaling pathway of the OmpR-mediated osmoregulatory expression of OmpC and OmpF in Escherichia coli. Biosci Biotechnol Biochem. 1999;63:408-14 pubmed
    ..A model for the alternative phosphotransfer signaling pathway involved in the phosphorylation of OmpR is proposed. ..
  4. Matsubara M, Mizuno T. The SixA phospho-histidine phosphatase modulates the ArcB phosphorelay signal transduction in Escherichia coli. FEBS Lett. 2000;470:118-24 pubmed
    ..We propose a novel mechanism, involving an HPt domain and a phospho-histidine phosphatase, by which a given multi-step His-to-Asp signaling can be modulated. ..
  5. Rezuchova B, Miticka H, Homerova D, Roberts M, Kormanec J. New members of the Escherichia coli sigmaE regulon identified by a two-plasmid system. FEMS Microbiol Lett. 2003;225:1-7 pubmed
  6. Hamada K, Kato M, Shimizu T, Ihara K, Mizuno T, Hakoshima T. Crystal structure of the protein histidine phosphatase SixA in the multistep His-Asp phosphorelay. Genes Cells. 2005;10:1-11 pubmed
    ..The tungstate ion, which mimics the substrate phosphate group, is located at the centre of the active site where the active residue, His8, points to the tungsten atom in the mode of in-line nucleophilic attack. ..
  7. Rigden D. The histidine phosphatase superfamily: structure and function. Biochem J. 2008;409:333-48 pubmed
  8. Hakoshima T, Ichihara H. Structure of SixA, a histidine protein phosphatase of the ArcB histidine-containing phosphotransfer domain in Escherichia coli. Methods Enzymol. 2007;422:288-304 pubmed
    ..Structure-based examination and multiple alignment of sequences revealed SixA active residues from loop beta1-H2, which might assist in the identification of SixA homologs among RHG phosphatases even with poor amino acid identity. ..