Gene Symbol: pgpA
Description: phosphatidylglycerophosphatase A
Alias: ECK0412, JW0408, yajN
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Funk C, Zimniak L, Dowhan W. The pgpA and pgpB genes of Escherichia coli are not essential: evidence for a third phosphatidylglycerophosphate phosphatase. J Bacteriol. 1992;174:205-13 pubmed
    ..conversion of phosphatidylglycerophosphate to phosphatidylglycerol in Escherichia coli, we disrupted two genes (pgpA and pgpB) which had previously been shown to encode gene products which carried out this reaction in vitro (T...
  2. Chang Y, Kennedy E. Phosphatidyl glycerophosphate phosphatase. J Lipid Res. 1967;8:456-62 pubmed
    ..It requires Mg(++) for activity and is inhibited by sulfhydryl agents. Some other properties of the enzyme are also described. ..
  3. Icho T, Raetz C. Multiple genes for membrane-bound phosphatases in Escherichia coli and their action on phospholipid precursors. J Bacteriol. 1983;153:722-30 pubmed
    ..enzymes capable of dephosphorylating PGP, as judged by the characterization of mutations in two genes designated pgpA and pgpB. The former is located near min 10 and is cotransducible with proC and dnaZ...
  4. Osman C, Haag M, Wieland F, Brugger B, Langer T. A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. 2010;29:1976-87 pubmed publisher
    ..Expression of a mitochondrially targeted variant of Escherichia coli phosphatase PgpA restores CL levels in Gep4-deficient cells, indicating functional conservation...
  5. Icho T. Membrane-bound phosphatases in Escherichia coli: sequence of the pgpA gene. J Bacteriol. 1988;170:5110-6 pubmed
    One of the phosphatidyl glycerophosphate phosphatase genes of Escherichia coli, pgpA, was cloned, and its DNA sequence was determined...
  6. Torrents E, Grinberg I, Gorovitz Harris B, Lundström H, Borovok I, Aharonowitz Y, et al. NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes. J Bacteriol. 2007;189:5012-21 pubmed
    ..The model assumes that differences in the positions of the NrdR binding sites, and in the sequences of the motifs themselves, determine the extent to which NrdR represses the transcription of each RNR operon. ..
  7. Lu Y, Guan Z, Zhao J, Raetz C. Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli. J Biol Chem. 2011;286:5506-18 pubmed publisher
    ..1% of the total lipid). Dephosphorylation of PGP to PG is catalyzed by several PGP-phosphatases. The pgpA and pgpB genes, which encode structurally distinct PGP-phosphatases, were identified previously...