ompC

Summary

Gene Symbol: ompC
Description: outer membrane porin protein C
Alias: ECK2207, JW2203, butR, meoA, par
Species: Escherichia coli str. K-12 substr. MG1655
Products:     ompC

Top Publications

  1. Samartzidou H, Delcour A. Excretion of endogenous cadaverine leads to a decrease in porin-mediated outer membrane permeability. J Bacteriol. 1999;181:791-8 pubmed
    ..mere expression of cadC, in the absence of cadaverine production, leads to a reduction in the amounts of OmpF and OmpC proteins, which suggests a novel mechanism for the environmental control of porin expression...
  2. Samartzidou H, Mehrazin M, Xu Z, Benedik M, Delcour A. Cadaverine inhibition of porin plays a role in cell survival at acidic pH. J Bacteriol. 2003;185:13-9 pubmed
    ..to understand the physiological significance of cadaverine excretion and the inhibition of porins, we isolated an OmpC mutant that showed resistance to spermine during growth and polyamine-resistant porin-mediated fluxes...
  3. Fukuchi J, Kashiwagi K, Yamagishi M, Ishihama A, Igarashi K. Decrease in cell viability due to the accumulation of spermidine in spermidine acetyltransferase-deficient mutant of Escherichia coli. J Biol Chem. 1995;270:18831-5 pubmed
    ..They included ribosome modulation factor and OmpC protein...
  4. Mizuno T, Mizushima S. Signal transduction and gene regulation through the phosphorylation of two regulatory components: the molecular basis for the osmotic regulation of the porin genes. Mol Microbiol. 1990;4:1077-82 pubmed
    Expression of Escherichia coli outer-membrane porin proteins (OmpF and OmpC) is regulated by the osmolarity of the medium...
  5. Mizuno T, Chou M, Inouye M. A comparative study on the genes for three porins of the Escherichia coli outer membrane. DNA sequence of the osmoregulated ompC gene. J Biol Chem. 1983;258:6932-40 pubmed
    The DNA sequence of the ompC gene which encodes one of the outer membrane porins has been determined...
  6. Douchin V, Bohn C, Bouloc P. Down-regulation of porins by a small RNA bypasses the essentiality of the regulated intramembrane proteolysis protease RseP in Escherichia coli. J Biol Chem. 2006;281:12253-9 pubmed
    ..the property that small RNAs are often involved in RNA-RNA interactions to capture RseX putative partners; ompA and ompC mRNA, which encode two major outer membrane proteins, were identified...
  7. Kirkpatrick C, Maurer L, Oyelakin N, Yoncheva Y, Maurer R, Slonczewski J. Acetate and formate stress: opposite responses in the proteome of Escherichia coli. J Bacteriol. 2001;183:6466-77 pubmed
  8. Darcan C, Ozkanca R, Flint K. Survival of nonspecific porin-deficient mutants of Escherichia coli in black sea water. Lett Appl Microbiol. 2003;37:380-5 pubmed
    ..The type of omp mutation has a significant impact in bacterial survival. The double OmpC-OmpF mutant and the OmpR mutant (which was incapable of synthesizing OmpC and OmpF) survived poorly compared with ..
  9. Sundara Baalaji N, Mathew M, Krishnaswamy S. Functional assay of Salmonella typhi OmpC using reconstituted large unilamellar vesicles: a general method for characterization of outer membrane proteins. Biochimie. 2006;88:1419-24 pubmed
    The immunodominant trimeric beta-barrel outer membrane protein OmpC from Salmonella typhi, the causative agent of typhoid, has been functionally characterized here...

More Information

Publications71

  1. Molloy M, Herbert B, Walsh B, Tyler M, Traini M, Sanchez J, et al. Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis. Electrophoresis. 1998;19:837-44 pubmed publisher
    ..coli, while OmpC, OmpT and OmpTOLC have not previously been identified on a 2-D gel...
  2. Egler M, Grosse C, Grass G, Nies D. Role of the extracytoplasmic function protein family sigma factor RpoE in metal resistance of Escherichia coli. J Bacteriol. 2005;187:2297-307 pubmed
    ..Genes showing decreased expression were part of the RpoE modulon itself plus the ompC gene, encoding a major outer membrane protein...
  3. Pan Y, Liao C, Kuo C, Duan K, Liang P, Yuan H, et al. The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin-producing Escherichia coli. J Biol Chem. 2006;281:13083-91 pubmed
    ..experimental results further indicated that exogenous polyamines suppress the expression of TolA, BtuB, OmpF, and OmpC proteins that are responsible for ColE7 uptake...
  4. Mattison K, Oropeza R, Byers N, Kenney L. A phosphorylation site mutant of OmpR reveals different binding conformations at ompF and ompC. J Mol Biol. 2002;315:497-511 pubmed
    ..the OmpF porin at low osmolarity, and at high osmolarity represses ompF transcription and activates expression of OmpC. We have characterized a substitution in the amino-terminal phosphorylation domain of OmpR, T83I, its phenotype is ..
  5. Gutierrez C, Barondess J, Manoil C, Beckwith J. The use of transposon TnphoA to detect genes for cell envelope proteins subject to a common regulatory stimulus. Analysis of osmotically regulated genes in Escherichia coli. J Mol Biol. 1987;195:289-97 pubmed
    ..Osmo-inducible fusions of phoA were found to ompC and to a gene that is probably proU...
  6. Mizuno T, Chou M, Inouye M. DNA sequence of the promoter region of the ompC gene and the amino acid sequence of the signal peptide of pro-OmpC protein of Escherichia coli. FEBS Lett. 1983;151:159-64 pubmed
    The osmoregulated ompC gene of Escherichia coli was cloned and the DNA sequence of a fragment encompassing the promoter region and a portion of the coding region was determined...
  7. Misra R, Benson S. Genetic identification of the pore domain of the OmpC porin of Escherichia coli K-12. J Bacteriol. 1988;170:3611-7 pubmed
    We have isolated and characterized 31 mutations in the ompC gene which allow Escherichia coli to grow on maltotriose (Dex+) in the absence of the LamB and OmpF porins...
  8. Kaeriyama M, Machida K, Kitakaze A, Wang H, Lao Q, Fukamachi T, et al. OmpC and OmpF are required for growth under hyperosmotic stress above pH 8 in Escherichia coli. Lett Appl Microbiol. 2006;42:195-201 pubmed
    ..Escherichia coli mutants deficient in ompC, ompF and both genes were constructed and the growth of these mutants was observed at alkaline pH...
  9. Bocquet Pages C, Lazdunski C, Lazdunski A. Lipid-synthesis-dependent biosynthesis (or assembly) of major outer-membrane proteins of Escherichia coli. Eur J Biochem. 1981;118:105-11 pubmed
    ..of the outer membranes, analyzed after pulse radiolabelling by [35S]methionine, was mainly altered in OmpF and OmpC proteins. These proteins are the main porins used by most nutrients like 5' AMP...
  10. Urban J, Vogel J. Translational control and target recognition by Escherichia coli small RNAs in vivo. Nucleic Acids Res. 2007;35:1018-37 pubmed
    ..We expect our GFP fusion approach to be applicable to sRNA targets of other bacteria, and also demonstrate that Vibrio RyhB sRNA represses a Vibrio sodB fusion when co-expressed in E.coli. ..
  11. Liu X, Ferenci T. An analysis of multifactorial influences on the transcriptional control of ompF and ompC porin expression under nutrient limitation. Microbiology. 2001;147:2981-9 pubmed
    ..In contrast, ompC expression was higher under N limitation...
  12. Sallmann F, Baveye Descamps S, Pattus F, Salmon V, Branza N, Spik G, et al. Porins OmpC and PhoE of Escherichia coli as specific cell-surface targets of human lactoferrin. Binding characteristics and biological effects. J Biol Chem. 1999;274:16107-14 pubmed
    ..We studied the interactions of human lactoferrin with the three major porins of Escherichia coli OmpC, OmpF, and PhoE. Binding experiments were performed on both purified porins and porin-deficient E...
  13. Xiong X, Deeter J, Misra R. Assembly-defective OmpC mutants of Escherichia coli K-12. J Bacteriol. 1996;178:1213-5 pubmed
    Novel ompC(Dex) alleles were utilized to isolate mutants defective in OmpC biogenesis...
  14. Goh E, Siino D, Igo M. The Escherichia coli tppB (ydgR) gene represents a new class of OmpR-regulated genes. J Bacteriol. 2004;186:4019-24 pubmed
    ..In this study, we examined the expression of a new OmpR-regulated gene, ydgR. Our results indicate that ydgR is equivalent to the Salmonella enterica serovar Typhimurium tppB gene and represents a new class of OmpR-regulated genes. ..
  15. Wang Y, Wang L, Sun Y, Chen Y, Zhu L, Guo L, et al. Disrupted OmpC causes osmosis sensitivity of Escherichia coli in alkaline medium. J Genet Genomics. 2007;34:1131-8 pubmed
    ..construction of mutant strains by homologous recombination and subcloning of DNA fragment techniques, gene ompC was identified as the key factor that, once disrupted, caused osmosis-sensitivity of E...
  16. Sugawara E, Kojima S, Nikaido H. Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow More Efficient Diffusion of β-Lactams than Their Escherichia coli Homologs OmpF and OmpC. J Bacteriol. 2016;198:3200-3208 pubmed
    ..showed that OmpK35 and OmpK36 produced larger more permeable channels than their Escherichia coli homologs OmpF and OmpC; OmpK35 especially produced a diffusion channel of remarkably high permeability toward lipophilic (benzylpenicillin)..
  17. Werner J, Misra R. YaeT (Omp85) affects the assembly of lipid-dependent and lipid-independent outer membrane proteins of Escherichia coli. Mol Microbiol. 2005;57:1450-9 pubmed
    ..Our data suggest that YaeT's role in the assembly of OMPs is not mediated through a role in lipid biogenesis, as debated for Omp85 in Neisseria, thus advocating a conserved OMP assembly function of Omp85 homologues. ..
  18. Basle A, Rummel G, Storici P, Rosenbusch J, Schirmer T. Crystal structure of osmoporin OmpC from E. coli at 2.0 A. J Mol Biol. 2006;362:933-42 pubmed
    Porins form transmembrane pores in the outer membrane of Gram-negative bacteria with matrix porin OmpF and osmoporin OmpC from Escherichia coli being differentially expressed depending on environmental conditions...
  19. Johansen J, Rasmussen A, Overgaard M, Valentin Hansen P. Conserved small non-coding RNAs that belong to the sigmaE regulon: role in down-regulation of outer membrane proteins. J Mol Biol. 2006;364:1-8 pubmed
    ..Transient induction of RybB resulted in decreased levels of the mRNAs encoding OmpC and OmpW. sigmaE -mediated regulation of ompC and ompW expression was abolished in strains lacking RybB or Hfq...
  20. Samuel Raj V, Füll C, Yoshida M, Sakata K, Kashiwagi K, Ishihama A, et al. Decrease in cell viability in an RMF, sigma(38), and OmpC triple mutant of Escherichia coli. Biochem Biophys Res Commun. 2002;299:252-7 pubmed
    ..of ribosome modulation factor (RMF), the sigma(38) subunit of RNA polymerase, and the outer membrane protein C (OmpC)...
  21. Misra R, Benson S. Isolation and characterization of OmpC porin mutants with altered pore properties. J Bacteriol. 1988;170:528-33 pubmed
    ..The mutation conferring the Dex+ phenotype in the majority of these mutants has been mapped to the ompC locus...
  22. Surrey T, Jähnig F. Kinetics of folding and membrane insertion of a beta-barrel membrane protein. J Biol Chem. 1995;270:28199-203 pubmed
    ..The partially folded state in the membrane is interpreted as the analogue of the molten globule state of soluble proteins. ..
  23. Simonet V, Mallea M, Fourel D, Bolla J, Pages J. Crucial domains are conserved in Enterobacteriaceae porins. FEMS Microbiol Lett. 1996;136:91-7 pubmed
    ..The presence of these common peptides suggested a conservation of specific regions involved in the functional organization of the enterobacterial porins. ..
  24. Misra R. A novel ompC mutation of Escherichia coli K-12 that reduces OmpC and OmpF levels in the outer membrane. Mol Microbiol. 1993;10:1029-35 pubmed
    A novel ompC mutation was isolated that not only lowered the amount of its own product, OmpC27, but also reduced the level of OmpF present in the outer membrane...
  25. Srividhya K, Krishnaswamy S. A simulation model of Escherichia coli osmoregulatory switch using E-CELL system. BMC Microbiol. 2004;4:44 pubmed
    ..comprising of the sensor, EnvZ and the cognate response regulator, OmpR, which together control the expression of OmpC and OmpF porins in response to the osmolyte concentration...
  26. Batchelor E, Silhavy T, Goulian M. Continuous control in bacterial regulatory circuits. J Bacteriol. 2004;186:7618-25 pubmed
    ..This mode of control is particularly interesting for an organism such as E. coli, which proliferates in diverse environments, and raises important questions regarding the biologically relevant inputs and outputs for this system. ..
  27. Henry T, Pommier S, Journet L, Bernadac A, Gorvel J, Lloubes R. Improved methods for producing outer membrane vesicles in Gram-negative bacteria. Res Microbiol. 2004;155:437-46 pubmed
    ..coli or Shigella flexneri cell envelope and to induce production of high amounts of vesicles. This technique was further found to work efficiently in Salmonella enterica serovar Typhimurium. ..
  28. Nikaido H, Vaara M. Molecular basis of bacterial outer membrane permeability. Microbiol Rev. 1985;49:1-32 pubmed
  29. Yohannes E, Thurber A, Wilks J, Tate D, Slonczewski J. Polyamine stress at high pH in Escherichia coli K-12. BMC Microbiol. 2005;5:59 pubmed
    ..During log-phase growth at pH 7.0, 1 mM spermine induced eight proteins, including PykF, GlpK, SerS, DeaD, OmpC and OmpF. Proteins repressed included acetate-inducible enzymes (YfiD, Pta, Lpd) as well as RapA (HepA), and FabB...
  30. Yang Y, Inouye M. Intermolecular complementation between two defective mutant signal-transducing receptors of Escherichia coli. Proc Natl Acad Sci U S A. 1991;88:11057-61 pubmed
    ..between Tar, an aspartate chemoreceptor, and EnvZ, an osmosensor of Escherichia coli that is able to induce ompC expression by phosphorylating OmpR (a transcriptional activator) in response to aspartate...
  31. Lin X, Li H, Wang C, Peng X. Proteomic analysis of nalidixic acid resistance in Escherichia coli: identification and functional characterization of OM proteins. J Proteome Res. 2008;7:2399-405 pubmed publisher
    ..The OM proteins TolC, OmpT, OmpC and OmpW were found to be up-regulated, and FadL was down-regulated in the NA-resistant E. coli strains...
  32. Han M, Lee S, Hong S. Comparative analysis of envelope proteomes in Escherichia coli B and K-12 strains. J Microbiol Biotechnol. 2012;22:470-8 pubmed
    ..Thus, these findings suggest that E. coli K-12 and its derivatives will be more favorable strains in certain biotechnological applications, such as cell surface display or membrane engineering studies. ..
  33. Tran Q, Williams S, Farid R, Erdemli G, Pearlstein R. The translocation kinetics of antibiotics through porin OmpC: insights from structure-based solvation mapping using WaterMap. Proteins. 2013;81:291-9 pubmed publisher
    ..coli porin OmpC. WaterMap was used to estimate the total water transfer energies resulting from transient occupation by each ..
  34. Jeanteur D, Lakey J, Pattus F. The bacterial porin superfamily: sequence alignment and structure prediction. Mol Microbiol. 1991;5:2153-64 pubmed
    ..Using the constraints of beta-sheet structure these porins are predicted to contain 16 membrane-spanning strands, 14 of which are common to the two (enteric and the neisserial) porin subfamilies. ..
  35. Utsumi R, Horie T, Katoh A, Kaino Y, Tanabe H, Noda M. Isolation and characterization of the heat-responsive genes in Escherichia coli. Biosci Biotechnol Biochem. 1996;60:309-15 pubmed
    The ompC gene expression is induced by increasing temperature as well as osmotic pressure...
  36. Nikaido H. Porins and specific channels of bacterial outer membranes. Mol Microbiol. 1992;6:435-42 pubmed
    ..Although lipopolysaccharides seem to play a significant role in the final assembly of the trimeric porins, the details of the targeting process still remain to be elucidated. ..
  37. Norioka S, Ramakrishnan G, Ikenaka K, Inouye M. Interaction of a transcriptional activator, OmpR, with reciprocally osmoregulated genes, ompF and ompC, of Escherichia coli. J Biol Chem. 1986;261:17113-9 pubmed
    The ompB locus, comprised of the genes ompR and envZ, regulates the expression of the genes ompF and ompC that encode the major porin proteins in the outer membrane of Escherichia coli K-12...
  38. Beis K, Whitfield C, Booth I, Naismith J. Two-step purification of outer membrane proteins. Int J Biol Macromol. 2006;39:10-4 pubmed
    ..We have tested this protocol for the purification of Wza and Osmoporin C (OmpC) proteins...
  39. Michalodimitrakis K, Sourjik V, Serrano L. Plasticity in amino acid sensing of the chimeric receptor Taz. Mol Microbiol. 2005;58:257-66 pubmed
    ..attractant ligands normally sensed by Tar and it interacts with Taz to induce OmpR-dependent transcription from the ompC promoter--albeit with reduced sensitivity relative to the chemotactic response it evokes via Tar...
  40. Rowbury R, Hussain N. Exposure of Escherichia coli to acid habituation conditions sensitizes it to alkaline stress. Lett Appl Microbiol. 1996;22:57-61 pubmed
    ..5 plus DNA gyrase inhibitors and was markedly reduced by himA, himD, hns, ompC and nhaA lesions. A tonB deletion mutant showed alkali sensitivity at pHo 7.0...
  41. CastilloKeller M, Misra R. Protease-deficient DegP suppresses lethal effects of a mutant OmpC protein by its capture. J Bacteriol. 2003;185:148-54 pubmed
    ..We report here that the expression of a mutant OmpC protein, OmpC(2Cys), which forms disulfide bonds in the periplasm due to the presence of two non-native cysteine ..
  42. Chong Z, Woo W, Chng S. Osmoporin OmpC forms a complex with MlaA to maintain outer membrane lipid asymmetry in Escherichia coli. Mol Microbiol. 2015;98:1133-46 pubmed publisher
    ..we demonstrate that in Escherichia coli, the Mla system maintains OM lipid asymmetry with the help of osmoporin OmpC. We show that the OM lipoprotein MlaA interacts specifically with OmpC and OmpF...
  43. Kleinschmidt J, Tamm L. Folding intermediates of a beta-barrel membrane protein. Kinetic evidence for a multi-step membrane insertion mechanism. Biochemistry. 1996;35:12993-3000 pubmed
  44. Wu L, Lin X, Peng X. From proteome to genome for functional characterization of pH-dependent outer membrane proteins in Escherichia coli. J Proteome Res. 2009;8:1059-70 pubmed publisher
    ..Among the differentially expressed proteins identified, OstA, TolC, OmpT, OmpP OmpC, Trak, OmpX, Dps, LamB, Tsx, FadL, OmpW, and OmpF were characterized as pH-related OM proteins...
  45. Vakharia H, Misra R. A genetic approach for analysing surface-exposed regions of the OmpC protein of Escherichia coli K-12. Mol Microbiol. 1996;19:881-9 pubmed
    ..We have identified surface exposed residues of OmpC that are important for phage binding...
  46. Xu C, Lin X, Ren H, Zhang Y, Wang S, Peng X. Analysis of outer membrane proteome of Escherichia coli related to resistance to ampicillin and tetracycline. Proteomics. 2006;6:462-73 pubmed
    ..Among the proteins, 3 were known as antibiotic-resistant proteins, including TolC, OmpC and YhiU, while FimD precursor, LamB, Tsx, YfiO, OmpW, NlpB were first reported here to be antibiotic-resistance-..
  47. Liu N, Samartzidou H, Lee K, Briggs J, Delcour A. Effects of pore mutations and permeant ion concentration on the spontaneous gating activity of OmpC porin. Protein Eng. 2000;13:491-500 pubmed
    ..altered charge distribution at the eyelet and compared their electrophysiological behavior with that of wild-type OmpC. We found that some mutations lead to changes in the spontaneous gating activity of OmpC porin channels...
  48. Sharma O, Yamashita E, Zhalnina M, Zakharov S, Datsenko K, Wanner B, et al. Structure of the complex of the colicin E2 R-domain and its BtuB receptor. The outer membrane colicin translocon. J Biol Chem. 2007;282:23163-70 pubmed
    ..Screening of porin knock-out mutants showed that either OmpF or OmpC can function in such a translocon...
  49. Bore E, Hebraud M, Chafsey I, Chambon C, Skjaeret C, Moen B, et al. Adapted tolerance to benzalkonium chloride in Escherichia coli K-12 studied by transcriptome and proteome analyses. Microbiology. 2007;153:935-46 pubmed
    ..The results revealed that BC treatment might result in superoxide stress in E. coli. ..
  50. Huang L, Tsui P, Freundlich M. Integration host factor is a negative effector of in vivo and in vitro expression of ompC in Escherichia coli. J Bacteriol. 1990;172:5293-8 pubmed
    ..coli and some of its bacteriophages and plasmids. We report here that IHF is a direct negative effector of the ompC operon of E. coli...
  51. Molloy M, Herbert B, Slade M, Rabilloud T, Nouwens A, Williams K, et al. Proteomic analysis of the Escherichia coli outer membrane. Eur J Biochem. 2000;267:2871-81 pubmed
    ..In an additional demonstration we show the value of parallel protein analysis to document changes in E. coli OMP expression as influenced by culture temperature...
  52. Maeda S, Takayanagi K, Nishimura Y, Maruyama T, Sato K, Mizuno T. Activation of the osmoregulated ompC gene by the OmpR protein in Escherichia coli: a study involving synthetic OmpR-binding sequences. J Biochem. 1991;110:324-7 pubmed
    Expression of the Escherichia coli outer membrane proteins, OmpC and OmpF, is regulated in response to the medium osmolarity...
  53. McBroom A, Johnson A, Vemulapalli S, Kuehn M. Outer membrane vesicle production by Escherichia coli is independent of membrane instability. J Bacteriol. 2006;188:5385-92 pubmed
    ..Mutations causing vesicle overproduction did not result in upregulation of the ompC gene encoding a major outer membrane protein...
  54. Yoshida T, Qin L, Egger L, Inouye M. Transcription regulation of ompF and ompC by a single transcription factor, OmpR. J Biol Chem. 2006;281:17114-23 pubmed
    The ompF and ompC genes of Escherichia coli are reciprocally regulated by a single transcription factor, phosphorylated OmpR (OmpR-P), depending upon medium osmolarity...
  55. Batchelor E, Walthers D, Kenney L, Goulian M. The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC. J Bacteriol. 2005;187:5723-31 pubmed
    ..mutagenesis of a two-color fluorescent reporter strain to identify new regulators of the porin genes ompF and ompC in Escherichia coli...
  56. Nogami T, Mizuno T, Mizushima S. Construction of a series of ompF-ompC chimeric genes by in vivo homologous recombination in Escherichia coli and characterization of the translational products. J Bacteriol. 1985;164:797-801 pubmed
    OmpF and OmpC are major outer membrane proteins. Although they are homologous proteins, they function differently in several respects...
  57. Verhoef C, Lugtenberg B, van Boxtel R, de Graaff P, Verheij H. Genetics and biochemistry of the peptidoglycan-associated proteins b and c of Escherichia coli K12. Mol Gen Genet. 1979;169:137-46 pubmed
    ..Genetic analysis showed three linkage groups, corresponding with the genes tolF (phenotype b-c+), meoA (phenotype b+c-) and ompB (phenotypes b-c-, b-c+, b++c- and b++c+/-)...
  58. Zhang D, Jiang B, Xiang Z, Wang S. Functional characterisation of altered outer membrane proteins for tetracycline resistance in Escherichia coli. Int J Antimicrob Agents. 2008;32:315-9 pubmed publisher
    ..In this study, upregulation of FimD, Tsx, OmpW, OmpC and TolC and downregulation of LamB in response to tetracycline were detected and confirmed by two-dimensional gel ..
  59. Sundara Baalaji N, Acharya K, Singh T, Krishnaswamy S. High-resolution diffraction from crystals of a membrane-protein complex: bacterial outer membrane protein OmpC complexed with the antibacterial eukaryotic protein lactoferrin. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:773-5 pubmed
    Crystals of the complex formed between the outer membrane protein OmpC from Escherichia coli and the eukaryotic antibacterial protein lactoferrin from Camelus dromedarius (camel) have been obtained using a detergent environment...
  60. Sato T, Yura T. Regulatory mutations conferring constitutive synthesis of major outer membrane proteins (OmpC and OmpF) in Escherichia coli. J Bacteriol. 1981;145:88-96 pubmed
    An ompB strain of Escherichia coli K-12 lacking major outer membrane proteins OmpC and OmpF was used to isolate a pair of mutants that have restored the ability to synthesize either OmpC or OmpF protein...
  61. Matsubara M, Kitaoka S, Takeda S, Mizuno T. Tuning of the porin expression under anaerobic growth conditions by his-to-Asp cross-phosphorelay through both the EnvZ-osmosensor and ArcB-anaerosensor in Escherichia coli. Genes Cells. 2000;5:555-69 pubmed
    ..standard aerobic growth conditions, it is well known that the osmoregulatory profile of the outer membrane porins (OmpC and OmpF) is mainly regulated by the EnvZ-OmpR phosphorelay system in response to medium osmolarity...
  62. Castillo Keller M, Vuong P, Misra R. Novel mechanism of Escherichia coli porin regulation. J Bacteriol. 2006;188:576-86 pubmed
    ..coli porin regulation was discovered from multicopy suppressors that permitted growth of cells expressing a mutant OmpC protein in the absence of DegP. Analyses of two suppressors showed that both substantially lowered OmpC expression...