Gene Symbol: nrdR
Description: Nrd regulon repressor
Alias: ECK0407, JW0403, ribX, ybaD
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Rodionov D, Gelfand M. Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling. Trends Genet. 2005;21:385-9 pubmed publisher
    ..A highly conserved palindromic signal with consensus acaCwAtATaTwGtg, named NrdR-box, was identified upstream of most operons encoding ribonuleotide reductases from three different classes...
  2. Dreux N, del Mar Cendra M, Massier S, Darfeuille Michaud A, Barnich N, Torrents E. Ribonucleotide reductase NrdR as a novel regulator for motility and chemotaxis during adherent-invasive Escherichia coli infection. Infect Immun. 2015;83:1305-17 pubmed publisher
    ..Knockout of the nrdR and nrdD genes, which encode a transcriptional regulator of RNRs and class III anaerobic RNR, respectively, ..
  3. Taura T, Ueguchi C, Shiba K, Ito K. Insertional disruption of the nusB (ssyB) gene leads to cold-sensitive growth of Escherichia coli and suppression of the secY24 mutation. Mol Gen Genet. 1992;234:429-32 pubmed
    ..5 min rather than 11 min as previously assigned. It is located at the distal end of an operon that contains a gene showing significant homology with a Bacillus subtilis gene involved in riboflavin biosynthesis. ..
  4. Tuggle C, Fuchs J. Regulation of the operon encoding ribonucleotide reductase in Escherichia coli: evidence for both positive and negative control. EMBO J. 1986;5:1077-85 pubmed
    ..These latter sites show sequence homology and probably interact since the effects of their individual deletion are not additive when combined. ..
  5. Torrents E, Grinberg I, Gorovitz Harris B, Lundström H, Borovok I, Aharonowitz Y, et al. NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes. J Bacteriol. 2007;189:5012-21 pubmed
    ..In this paper, we show that the E. coli YbaD protein differentially regulates the expression of the three sets of genes...
  6. McKethan B, Spiro S. Cooperative and allosterically controlled nucleotide binding regulates the DNA binding activity of NrdR. Mol Microbiol. 2013;90:278-89 pubmed publisher
    ..One of these, NrdR, has recently been shown to regulate all three nrd operons that encode RNR isoenzymes...
  7. Herrick J, Sclavi B. Ribonucleotide reductase and the regulation of DNA replication: an old story and an ancient heritage. Mol Microbiol. 2007;63:22-34 pubmed
    ..In this review we examine the role RNR plays in regulating the total rate of DNA synthesis in E. coli and, hence, in maintaining constant DNA/cell mass ratios during normal growth and under conditions of DNA stress. ..
  8. Naveen V, Hsiao C. NrdR Transcription Regulation: Global Proteome Analysis and Its Role in Escherichia coli Viability and Virulence. PLoS ONE. 2016;11:e0157165 pubmed publisher an important role in the synthesis of dNTPs and their expression is regulated by the transcription factors, NrdR and Fur...
  9. Tuggle C, Fuchs J. Regulation of the operon encoding ribonucleotide reductase: role of the negative sites in nrd repression. J Bacteriol. 1990;172:1711-8 pubmed

More Information


  1. Borovok I, Gorovitz B, Yanku M, Schreiber R, Gust B, Chater K, et al. Alternative oxygen-dependent and oxygen-independent ribonucleotide reductases in Streptomyces: cross-regulation and physiological role in response to oxygen limitation. Mol Microbiol. 2004;54:1022-35 pubmed publisher
    ..Likewise, the class II oxygen-independent RNR nrdJ gene forms an operon with a likely regulatory gene, nrdR, which encodes a protein possessing an ATP-cone domain like those present in the allosteric activity site of many ..